WormBase Tree Display for Gene: WBGene00000983

WBGene00000983 SMap: S_parent: Sequence: F35B12
  Identity: Version: 1
    Name: CGC_name: dhs-20 Person_evidence: WBPerson651
      Sequence_name: F35B12.2
      Molecular_name: F35B12.2
        F35B12.2.1
        CE39496
      Other_name: CELE_F35B12.2 Accession_evidence: NDB BX284605
      Public_name: dhs-20
    DB_info: Database: AceView gene 5M84
        WormQTL gene WBGene00000983
        WormFlux gene WBGene00000983
        NDB locus_tag CELE_F35B12.2
        Panther gene CAEEL|WormBase=WBGene00000983|UniProtKB=Q20012
          family PTHR43313
        NCBI gene 179590
        RefSeq protein NM_073540.6
        TrEMBL UniProtAcc Q20012
        UniProt_GCRP UniProtAcc Q20012
        OMIM gene 601617
            609769
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dhs
    Allele (29)
    RNASeq_FPKM (74)
    GO_annotation: 00066820
      00066821
      00066822
      00066823
    Ortholog (61)
    Paralog (38)
    Structured_description: Concise_description: dhs-20 encodes a short-chain dehydrogenase predicted to be mitochondrial. Paper_evidence: WBPaper00004424
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable oxidoreductase activity. Predicted to be involved in steroid metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13; fundus albipunctatus; and night blindness. Is an ortholog of several human genes including DHRS9 (dehydrogenase/reductase 9); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and RDH5 (retinol dehydrogenase 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080257 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:29958)
      DOID:11105 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9940)
      DOID:8499 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9940)
  Molecular_info: Corresponding_CDS: F35B12.2
    Corresponding_CDS_history: F35B12.2:wp87
      F35B12.2:wp152
    Corresponding_transcript: F35B12.2.1
    Other_sequence (75)
    Associated_feature: WBsf653131
      WBsf669390
      WBsf234552
  Experimental_info: RNAi_result: WBRNAi00014283 Inferred_automatically: RNAi_primary
      WBRNAi00046270 Inferred_automatically: RNAi_primary
      WBRNAi00046271 Inferred_automatically: RNAi_primary
      WBRNAi00031741 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1025422
      Expr1150162
      Expr2010904
      Expr2029143
    Drives_construct: WBCnstr00037159
    Construct_product: WBCnstr00037159
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00041954:ethanol_upregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044246:pgrn-1_ced-3_downregulated
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044638:daf-2(e1370)rsks-1(ok1255)_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045401:N.parisii_40h_downregulated
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046024:sleep_downregulated_oscillating
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046691:P1_enriched
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048926:miaserin_upregulated_adult-day5
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00049290:rsks-1(sv31)_upregulated
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00052868:ALA_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00054796:cav-1(RNAi)_downregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Psora_upregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:anterior-head_expressed
      WBPaper00055648:pharynx_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056167:ifo-1(kc2)_downregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L2
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058648:Y37A1B.5(RNAi)_upregulated
      WBPaper00058678:DAF-12_upregulated_PVD
      WBPaper00058711:skn-1(lax188)_downregulated
      WBPaper00058948:npr-8(ok1439)_upregulated_PA14
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059253:stearic-acid_upregulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060399:CoCl2_6hr_downregulated_N2
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061340:AMso
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061405:S.aureus_upregulated_starvation
      WBPaper00061527:dhs-28_22199-acs-14
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061653:alh-4(hj221)_upregulated
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062056:lin-36(we31)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062197:mec-8_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_upregulated_protein
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065392:Lb.gasseri_downregulated
      WBPaper00065392:Lb.plantarum_downregulated
      WBPaper00065392:Lb.reuteri_downregulated
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:Day5_vs_Day1_upregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:9_0
      WBPaper00065841:9_1
      WBPaper00065841:9_2
      WBPaper00065841:24_0
      WBPaper00065841:26_0
      WBPaper00065841:26_1
      WBPaper00065841:30_0
      WBPaper00065841:30_3
      WBPaper00065841:79_0
      WBPaper00065841:79_2
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066083:hlh-17p-jmjd-1.2_downregulated
      WBPaper00066118:cyclobutrifluram_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066204:CdCl2_downregulated_mRNA
      cgc4489_group_1
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00031850:mdt-15(RNAi)_downregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp2
      WBPaper00033101:spr-5_regulated
      WBPaper00034739:N2moreDR1350
      WBPaper00035479:daf-16(RNAi)_downregulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036286:Pattern_C
      WBPaper00037113:CPF_DZN_16C_up-regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040963:Q50_up
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HF_11d_0.2mM_Down
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041207:CE_dauer_up
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041609:hpl-1_hpl-2_upregulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045015:nhr-25(RNAi)_downregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00048929:ethosuximide_upregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00055899:nitroguanidine_regulated
      [cgc6390]:herm_soma-enriched
    Interaction (35)
  Map_info: Map: V Position: 3.21084 Error: 0.00022
    Positive: Positive_clone: F35B12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00042257
    WBPaper00045631
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene