WormBase Tree Display for Gene: WBGene00000962

WBGene00000962 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: T21E12
  Identity: Version: 1
    Name: CGC_name: dhc-1 Person_evidence: WBPerson1562
      Sequence_name: T21E12.4
      Molecular_name: T21E12.4a
        T21E12.4a.1
        CE23997
        T21E12.4b
        CE51690
        T21E12.4b.1
      Other_name: let-354
        spd-4
        CELE_T21E12.4 Accession_evidence: NDB BX284601
      Public_name: dhc-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (13)
  Disease_info: Experimental_model: DOID:1826 Homo sapiens Paper_evidence: WBPaper00028525
          Curator_confirmed: WBPerson324
          Date_last_updated: 24 Aug 2021 00:00:00
      DOID:0050453 Homo sapiens Paper_evidence: WBPaper00028525
          Accession_evidence: OMIM 607432
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Apr 2013 00:00:00
    Potential_model: DOID:0070043 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2961)
      DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2961)
      DOID:0070351 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2961)
      DOID:0110175 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2961)
    Disease_relevance: In humans, mutations in the LIS1 gene (Platelet activating factor acetylhydrolase, isoform 1B, alpha subunit; PAFAH1B1) and the LIS1 pathway, are implicated in Lissencephaly, a developmental abnormality associated with a failure of neuronal migration in the cerebral cortex, leading to mental retardation and epilepsy; human NDE1 and NDEL1, are effectors of LIS1; the elegans genetic model for epileptic siezures consists of lis-1 mutants that are responsive to the common seizure inducer pentylenetetrazole (PTZ) and diplay a distinct convulsive phenotype; studies in the worm show that dhc-1/dynein heavy chain (orthologous to human DYNC1H1), is a LIS1 pathway component and worms depleted for LIS1 pathway components via RNA interference, NUD-1, NUD-2, DHC-1, CDK-5, and CDKA-1, also exhibited significant convulsions following PTZ treatment; further nud-1 (orthologous to human NUDC), nud-2/NDE1 and cdk-5 show significant enhancement in convulsions in a lis-1 heterozygous background when compared with the wild-type background; these animals are also less likely to recover when PTZ treatment is removed, when compared to wild-type; these studies show that while knocking down target genes (lis-1, cdk-5, and cdka-1 that function in neuronal migration), and their interacting proteins like nud-1, nud-2 and dhc-1, does not yield spontaneous convulsions in C. elegans, further alterations in the neural environment through the application of PTZ serve to pass a critical threshold within these animals. Homo sapiens Curator_confirmed: WBPerson324
  Models_disease_in_annotation: WBDOannot00000150
    WBDOannot00001012
  Molecular_info: Corresponding_CDS: T21E12.4a
      T21E12.4b
    Corresponding_transcript: T21E12.4a.1
      T21E12.4b.1
    Other_sequence (122)
    Associated_feature: WBsf643215
      WBsf656205
      WBsf656206
      WBsf656207
      WBsf656208
      WBsf983394
      WBsf217528
      WBsf217529
  Experimental_info: RNAi_result (43)
    Expr_pattern (19)
    Drives_construct: WBCnstr00003093
      WBCnstr00007434
      WBCnstr00008880
      WBCnstr00013402
      WBCnstr00037176
      WBCnstr00042469
    Construct_product: WBCnstr00007434
      WBCnstr00008880
      WBCnstr00013402
      WBCnstr00037176
      WBCnstr00039347
      WBCnstr00042469
    Antibody: WBAntibody00000242
      WBAntibody00000917
      WBAntibody00002792
      WBAntibody00002860
    Microarray_results (20)
    Expression_cluster (137)
    Interaction (292)
    WBProcess: WBbiopr:00000017
  Map_info: Map: I Position: -1.31043 Error: 0.007943
    Well_ordered
    Positive: Positive_clone: T21E12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 2523
      Multi_point: 1007
        1758
        1759
        1760
        1761
        1762
        1763
        3862
      Pos_neg_data (15)
  Reference: WBPaper00000975
    WBPaper00001001
    WBPaper00001274
    WBPaper00001339
    WBPaper00002290
    WBPaper00002726
    WBPaper00002958
    WBPaper00003704
    WBPaper00003985
    WBPaper00004115
    WBPaper00004211
    WBPaper00004402
    WBPaper00004509
    WBPaper00004540
    WBPaper00005320
    WBPaper00005565
    WBPaper00005724
    WBPaper00006059
    WBPaper00006060
    WBPaper00006310
    WBPaper00006494
    WBPaper00010571
    WBPaper00013411
    WBPaper00013451
    WBPaper00016978
    WBPaper00017022
    WBPaper00018055
    WBPaper00018330
    WBPaper00018880
    WBPaper00018959
    WBPaper00019337
    WBPaper00021948
    WBPaper00024043
    WBPaper00024189
    WBPaper00024200
    WBPaper00024358
    WBPaper00024523
    WBPaper00025115
    WBPaper00025116
    WBPaper00025176
    WBPaper00025722
    WBPaper00026060
    WBPaper00026308
    WBPaper00026590
    WBPaper00026660
    WBPaper00026866
    WBPaper00027230
    WBPaper00027822
    WBPaper00028423
    WBPaper00028448
    WBPaper00028525
    WBPaper00028886
    WBPaper00029179
    WBPaper00029200
    WBPaper00029262
    WBPaper00029395
    WBPaper00030247
    WBPaper00030393
    WBPaper00030521
    WBPaper00030801
    WBPaper00030897
    WBPaper00031073
    WBPaper00031354
    WBPaper00031794
    WBPaper00032153
    WBPaper00032264
    WBPaper00032910
    WBPaper00033063
    WBPaper00033469
    WBPaper00033638
    WBPaper00034764
    WBPaper00034954
    WBPaper00035010
    WBPaper00035192
    WBPaper00035198
    WBPaper00035228
    WBPaper00035468
    WBPaper00035598
    WBPaper00036385
    WBPaper00036428
    WBPaper00037731
    WBPaper00037792
    WBPaper00037839
    WBPaper00037977
    WBPaper00038128
    WBPaper00038491
    WBPaper00038662
    WBPaper00039750
    WBPaper00040589
    WBPaper00041129
    WBPaper00041782
    WBPaper00041950
    WBPaper00042699
    WBPaper00043347
    WBPaper00043378
    WBPaper00043613
    WBPaper00044471
    WBPaper00045213
    WBPaper00045425
    WBPaper00045884
    WBPaper00045955
    WBPaper00046013
    WBPaper00046100
    WBPaper00048209
    WBPaper00048322
    WBPaper00048418
    WBPaper00049828
    WBPaper00050345
    WBPaper00051092
    WBPaper00051562
    WBPaper00052141
    WBPaper00052263
    WBPaper00052847
    WBPaper00054441
    WBPaper00055090
    WBPaper00055336
    WBPaper00056325
    WBPaper00057823
    WBPaper00057896
    WBPaper00057909
    WBPaper00060242
    WBPaper00060885
    WBPaper00060927
    WBPaper00061547
    WBPaper00063117
    WBPaper00064298
    WBPaper00064339
    WBPaper00065052
    WBPaper00065685
    WBPaper00066048
  Remark: Sequence connection from [Schmidt D, Strome S]
    Previous connection of genomic_sequence to dhc-14 was a typo [030225 ck1]
  Method: Gene