WormBase Tree Display for Gene: WBGene00000951
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| WBGene00000951 | SMap | S_parent | Sequence | K03B8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | deg-3 | Person_evidence | WBPerson95 | |||||
| Sequence_name | K03B8.9 | ||||||||
| Molecular_name | K03B8.9 | ||||||||
| K03B8.9.1 | |||||||||
| CE06083 | |||||||||
| K03B8.9.2 | |||||||||
| Other_name | CELE_K03B8.9 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | deg-3 | ||||||||
| DB_info | Database | AceView | gene | 5L894 | |||||
| WormQTL | gene | WBGene00000951 | |||||||
| WormFlux | gene | WBGene00000951 | |||||||
| NDB | locus_tag | CELE_K03B8.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000951|UniProtKB=P54244 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 3565200 | |||||||
| RefSeq | protein | NM_001392614.1 | |||||||
| SwissProt | UniProtAcc | P54244 | |||||||
| UniProt_GCRP | UniProtAcc | P54244 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | deg | ||||||||
| Allele (59) | |||||||||
| Legacy_information | dominant uncoordinated, contains degenerating cells. Pseudo-wildtype intragenic revertants u662u692, u662u693. | ||||||||
| [C.elegansII] u662 : dominant uncoordinated, Tab in tail; subset of neurons undergo progressive degeneration. See also des-2, des-3.OA: > 8 pseudo-wildtype intragenic revertants e.g. u662u692, u662u693 : wild type phenotype. Cloned: encodes alpha subunit of nicotinic acetylcholine receptor, u662 is missense change in second TM domain. [Treinin & Chalfie 1995] | |||||||||
| Strain | WBStrain00035045 | ||||||||
| WBStrain00035046 | |||||||||
| WBStrain00052613 | |||||||||
| WBStrain00052614 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Contained_in_operon | CEOP5284 | ||||||||
| Ortholog (34) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | deg-3 encodes an alpha subunit of a nicotinic acetylcholine receptor (nAChR); originally defined by a gain-of-function mutation that results in neuronal degeneration and uncoordinated movement, DEG-3 can form heteromeric channels with a second alpha subunit, DES-2, and in vivo these channels appear to be required for chemosensation of choline; deg-3 and des-2 reside in an operon, and consistent with their role in metabolite chemosensation, are expressed in nonsynaptic regions such as the sensory endings of the IL2 chemosensory neurons; DEG-3 and DES-2 are also detected in the touch cell neurons, M1 head muscles, FLP and PVD sensory neurons, and the PVC interneuron; in subsets of these neurons, DEG-3 expression is not detectable in mec-3 or unc-86 mutant backgrounds. | Paper_evidence | WBPaper00002167 | |||||
| WBPaper00003338 | |||||||||
| WBPaper00004621 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Sep 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in positive regulation of locomotion involved in locomotory behavior and regulation of programmed cell death. Predicted to be located in neuron projection and synapse. Expressed in ALA; AVG; PVC; and mechanosensory neurons. Used to study neurodegenerative disease. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1289 | Homo sapiens | Paper_evidence | WBPaper00002167 | ||||
| WBPaper00032364 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson38202 | |||||||||
| Date_last_updated | 22 May 2018 00:00:00 | ||||||||
| Disease_relevance | Defects in human sodium channel proteins cause several disorders including hyperkalemic periodic paralysis and paramyotonia congenita; Chloride channel defects produce cystic fibrosis and acetylcholine receptor defects underlie the congenital myasthenic syndromes. | Homo sapiens | Curator_confirmed | WBPerson324 | |||||
| Date_last_updated | 25 Nov 2014 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000334 | ||||||||
| WBDOannot00000526 | |||||||||
| Molecular_info | Corresponding_CDS | K03B8.9 | |||||||
| Corresponding_transcript | K03B8.9.1 | ||||||||
| K03B8.9.2 | |||||||||
| Other_sequence (22) | |||||||||
| Associated_feature | WBsf234533 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00102749 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00016526 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066377 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00049804 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027652 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr224 | ||||||||
| Expr9315 | |||||||||
| Expr1013101 | |||||||||
| Expr1030591 | |||||||||
| Expr1153524 | |||||||||
| Expr2010844 | |||||||||
| Expr2029082 | |||||||||
| Drives_construct | WBCnstr00010719 | ||||||||
| WBCnstr00013896 | |||||||||
| WBCnstr00037183 | |||||||||
| Construct_product | WBCnstr00014763 | ||||||||
| WBCnstr00037183 | |||||||||
| Antibody | WBAntibody00001595 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (43) | |||||||||
| Map_info | Map | V | Position | 3.08425 | Error | 0.002323 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | K03B8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| T21D1 | |||||||||
| Mapping_data | 2_point | 6220 | |||||||
| 7052 | |||||||||
| Multi_point | 2781 | ||||||||
| 2782 | |||||||||
| 3788 | |||||||||
| 3971 | |||||||||
| 4255 | |||||||||
| 4230 | |||||||||
| Reference (90) | |||||||||
| Remark | mutation isolated from 'nT1(dm)', a dominant unc and recessive lethal derivative of nT1. u662 is not recessive lethal. | ||||||||
| In an operon with des-2. email 20 from wen chen | |||||||||
| Method | Gene |
