[Sugimoto A] encodes a protein similar to human DAZ (Deleted in Azoospermia), includes a RNP-type RNA-binding motif and a DAZ-family-specific motif, tj3 (deletion allele) is defective in progression of meiosis during oogenesis, spermatogenesis unaffected.
daz-1 encodes a protein containing an RNA recognition motif that is required for the progression of meiosis during oogenesis; DAZ-1 is expressed in the germline, and expression levels peak in the proximal pachytene region; cpb-3(bt17);daz-1(tj3) hermaphrodites have a synthetic phenotype of total sterility and masculinization; DAZ-1 colocalizes with CPB-3 invivo, coimmunoprecipitates with CPB-3, and binds CPB-3 in two-hybrid assays.
Predicted to enable mRNA 3'-UTR binding activity and translation activator activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and positive regulation of translational initiation. Located in cytoplasm. Expressed in germ line; gonad; and in male. Is an ortholog of several human genes including DAZ1 (deleted in azoospermia 1); DAZ2 (deleted in azoospermia 2); and DAZ3 (deleted in azoospermia 3).
Sequence connection updated to .7 rather than .5 following advice of Danielle Thierry-Mieg. 02/06/12 krb.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.