WormBase Tree Display for Gene: WBGene00000934
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| WBGene00000934 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dat-1 | Person_evidence | WBPerson508 | |||||
| Sequence_name | T23G5.5 | ||||||||
| Molecular_name | T23G5.5 | ||||||||
| T23G5.5.1 | |||||||||
| CE25124 | |||||||||
| Other_name | CELE_T23G5.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | dat-1 | ||||||||
| DB_info | Database | AceView | gene | 3K335 | |||||
| WormQTL | gene | WBGene00000934 | |||||||
| WormFlux | gene | WBGene00000934 | |||||||
| NDB | locus_tag | CELE_T23G5.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000934|UniProtKB=Q03614 | |||||||
| family | PTHR11616 | ||||||||
| NCBI | gene | 176304 | |||||||
| RefSeq | protein | NM_066642.7 | |||||||
| SwissProt | UniProtAcc | Q03614 | |||||||
| UniProt_GCRP | UniProtAcc | Q03614 | |||||||
| OMIM | gene | 126455 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dat | ||||||||
| Allele (50) | |||||||||
| Strain | WBStrain00004026 | ||||||||
| WBStrain00004027 | |||||||||
| WBStrain00004031 | |||||||||
| WBStrain00004039 | |||||||||
| WBStrain00035179 | |||||||||
| WBStrain00040348 | |||||||||
| WBStrain00040349 | |||||||||
| WBStrain00033394 | |||||||||
| WBStrain00034689 | |||||||||
| WBStrain00051814 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (37) | |||||||||
| Ortholog (45) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | dat-1 encodes a plasma membrane dopamine transporter; DAT-1 is predicted to regulate dopaminergic neurotransmission via reuptake of dopamine into presynaptic neurons; when expressed in HeLa cells, DAT-1 exhibits high affinity, saturable dopamine transport; further, in primary cultures of C. elegans dopaminergic neurons, DAT-1 also exhibits a channel mode of conduction that leads to membrane depolarization; in hermaphrodites, dat-1 is expressed in the eight dopaminergic neurons (4 CEPs, 2 ADEs, and 2 PDEs), while in males dat-1 is additionally expressed in the three pairs of tail dopaminergic neurons; dat-1 expression begins during embryogenesis with the exception of expression in the PDE neurons which are born postembryonically. | Paper_evidence | WBPaper00003230 | |||||
| WBPaper00004653 | |||||||||
| WBPaper00005147 | |||||||||
| WBPaper00024866 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 30 May 2008 00:00:00 | ||||||||
| Automated_description | Enables amine transmembrane transporter activity; chloride channel activity; and dopamine:sodium symporter activity. Involved in several processes, including cellular response to amphetamine; nitrogen compound transport; and regulation of locomotion involved in locomotory behavior. Located in neuron projection membrane; neuronal cell body membrane; and presynaptic membrane. Expressed in dopaminergic neurons; tail; and in male. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; neurocirculatory asthenia; and nicotine dependence. Is an ortholog of human SLC6A2 (solute carrier family 6 member 2) and SLC6A3 (solute carrier family 6 member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0090145 | Homo sapiens | Curator_confirmed | WBPerson324 | ||||
| Date_last_updated | 06 Sep 2013 00:00:00 | ||||||||
| Potential_model | DOID:1094 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11049) | |||||
| DOID:0050742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11049) | ||||||
| DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11049) | ||||||
| DOID:0070489 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11049) | ||||||
| DOID:11569 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11048) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11048) | ||||||
| Models_disease_in_annotation | WBDOannot00000228 | ||||||||
| Molecular_info | Corresponding_CDS | T23G5.5 | |||||||
| Corresponding_transcript | T23G5.5.1 | ||||||||
| Other_sequence (13) | |||||||||
| Associated_feature | WBsf047511 | ||||||||
| WBsf047512 | |||||||||
| WBsf047513 | |||||||||
| WBsf993623 | |||||||||
| WBsf225537 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00006239 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00027843 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053978 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019106 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081643 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076706 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (114) | |||||||||
| Construct_product | WBCnstr00000122 | ||||||||
| WBCnstr00006212 | |||||||||
| WBCnstr00006213 | |||||||||
| WBCnstr00006214 | |||||||||
| WBCnstr00011373 | |||||||||
| WBCnstr00014901 | |||||||||
| WBCnstr00021628 | |||||||||
| WBCnstr00037190 | |||||||||
| WBCnstr00040427 | |||||||||
| Antibody | WBAntibody00001357 | ||||||||
| WBAntibody00001358 | |||||||||
| WBAntibody00001876 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (136) | |||||||||
| SAGE_tag | SAGE:acgtcaaaga | Strand | Sense | ||||||
| Unambiguously_mapped | |||||||||
| SAGE:caaaatgcaa | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:taaaaagcaa | Strand | Antisense | |||||||
| SAGE:acgtcaaagagatgatg | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:tagaatagtg | Strand | Antisense | |||||||
| Interaction (53) | |||||||||
| WBProcess | WBbiopr:00000078 | ||||||||
| Map_info | Map | III | Position | 0.361721 | Error | 0.009764 | |||
| Positive | Positive_clone | T23G5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5074 | |||||||
| Pseudo_map_position | |||||||||
| Reference (137) | |||||||||
| Remark | Sequence connection from [source J Rand] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
