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WormBase Tree Display for Gene: WBGene00000895

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Name Class

WBGene00000895SMapS_parentSequenceB0412
IdentityVersion1
NameCGC_namedac-1Person_evidenceWBPerson473
Sequence_nameB0412.1
Molecular_nameB0412.1a
B0412.1a.1
CE26848
B0412.1b
CE33550
B0412.1b.1
Other_nameski-1Person_evidenceWBPerson473
CELE_B0412.1Accession_evidenceNDBBX284603
Public_namedac-1
DB_infoDatabaseAceViewgene3B439
WormQTLgeneWBGene00000895
WormFluxgeneWBGene00000895
NDBlocus_tagCELE_B0412.1
PanthergeneCAEEL|WormBase=WBGene00000895|UniProtKB=H2KY91
familyPTHR12577
NCBIgene175238
RefSeqproteinNM_001025959.5
NM_001025958.4
SwissProtUniProtAccH2KY91
TREEFAMTREEFAM_IDTF316697
UniProt_GCRPUniProtAccH2KY91
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classdac
Allele (159)
StrainWBStrain00001324
WBStrain00001325
WBStrain00035649
WBStrain00035733
WBStrain00035736
RNASeq_FPKM (74)
GO_annotation00021457
00021458
00021459
00021460
00021461
00021462
00021463
00021464
00021465
Ortholog (36)
Structured_descriptionConcise_descriptiondac-1 encodes the C. elegans ortholog of Dachshund, a transcriptional regulator first described in Drosophila that is a member of the SKI/SNO/DAC family of proteins; dac-1 is expressed at higher levels in the AFD thermosensory neurons as compared to the AWB olfactory neurons and likely plays a role in thermosensory behavior as on thermal gradients dac-1 mutants fail to suppress cryophilic drive but continue to track isotherms at the cultivation temperature; a DAC-1::GFP fusion protein is nuclear and expressed strongly in the AFD thermosensory neurons, but weakly in the AWC, ASE, and ASK chemosensory neurons; expression is also seen in alae and additional, unidentified tail cells; dac-1 expression in AFD is positively regulated by the TTX-1 OTX-like homeodomain protein.Paper_evidenceWBPaper00024671
Curator_confirmedWBPerson1843
Date_last_updated21 May 2007 00:00:00
Automated_descriptionPredicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in thermotaxis. Located in nucleus. Expressed in amphid neurons; cuticular ala; and tail. Is an ortholog of human DACH1 (dachshund family transcription factor 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSB0412.1a
B0412.1b
Corresponding_CDS_historyB0412.1b:wp120
B0412.1b:wp123
Corresponding_transcriptB0412.1a.1
B0412.1b.1
Other_sequenceDviv_isotig11489
SSC00720_1
Dviv_isotig11488
SS02097
Associated_featureWBsf658584
WBsf978943
WBsf224400
Transcription_factorWBTranscriptionFactor000635
Experimental_infoRNAi_resultWBRNAi00028128Inferred_automaticallyRNAi_primary
WBRNAi00009756Inferred_automaticallyRNAi_primary
WBRNAi00006647Inferred_automaticallyRNAi_primary
WBRNAi00110961Inferred_automaticallyRNAi_primary
WBRNAi00039031Inferred_automaticallyRNAi_primary
Expr_patternChronogram2070
Expr3130
Expr5066
Expr7403
Expr1015167
Expr1143193
Expr1200045
Expr2010758
Expr2028995
Drives_constructWBCnstr00002217
WBCnstr00002218
WBCnstr00011158
WBCnstr00012546
WBCnstr00037214
Construct_productWBCnstr00011158
WBCnstr00016702
WBCnstr00037214
Microarray_results (24)
Expression_clusterWBPaper00029359_1280
WBPaper00029359_1297
WBPaper00029359_1310
WBPaper00029359_1364
WBPaper00029359_1444
WBPaper00029359_1504
WBPaper00029359_1578
WBPaper00029359_1604
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00038061:aldicarb_upregulated
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00040209:B.thuringiensis_downregulated_MY15
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00045316:prg-1_upregulated_L4
WBPaper00045774:clk-1_upregulated
WBPaper00046805:csr-1(RNAi)_upregulated_Set1
WBPaper00047132:skn-1(RNAi)_downregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00050163:let-418(RNAi)_downregulated_100-cell-embryo
WBPaper00050344:AFD-neuron_enriched
WBPaper00050344:ASER-neuron_enriched
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00051404:alg-1(gk214)_upregulated
WBPaper00051404:alg-2(ok304)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin-Psora_downregulated
WBPaper00055648:male-CEM-neurons_expressed
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00057041:spc-1(cas971)_upregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00059253:sucrose_stearic-acid_upregulated
WBPaper00059253:sucrose_upregulated
WBPaper00059334:sacy-1(depletion)_regulated
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00060445:nfki-1(cer1)_downregulated_L1
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:AFD
WBPaper00061527:K04C2.5-ZK1307.2
WBPaper00061651:AFD_enriched
WBPaper00061651:ASK_enriched
WBPaper00061651:AWC_OFF_enriched
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064769:him-17(me24)_upregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065158:25C_vs_15C_upregulated_AFD
WBPaper00065158:AFD_enriched
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065841:0_0
WBPaper00065841:35_0
WBPaper00065841:35_2
WBPaper00065841:35_3
WBPaper00065841:63_0
WBPaper00065841:77_0
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00024671:AFD_vs_AWB_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026952:class_D
WBPaper00032948:FedUp
WBPaper00034739:N2moreDR1350
WBPaper00036123:Atrazine_regulated
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00045960:L1-L4-lethargus_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
WBPaper00047070:N2_starvation_upregulated
Interaction (95)
WBProcessWBbiopr:00000010
Map_infoMapIIIPosition-25.7793Error0.003862
PositivePositive_cloneB0412Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4251
Pseudo_map_position
ReferenceWBPaper00010874
WBPaper00024524
WBPaper00024671
WBPaper00026952
WBPaper00027309
WBPaper00033137
WBPaper00034843
WBPaper00038491
WBPaper00055090
WBPaper00065158
Remarkski-1 became an other-name of dac-1 as this locus encodes the C. elegans ortholog of Dachshund, rather than of the related protein SKIPerson_evidenceWBPerson473
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene