WormBase Tree Display for Gene: WBGene00000877
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| WBGene00000877 | SMap | S_parent | Sequence | Y49A3A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cyn-1 | Person_evidence | WBPerson466 | |||||
| Sequence_name | Y49A3A.5 | ||||||||
| Molecular_name | Y49A3A.5 | ||||||||
| Y49A3A.5.1 | |||||||||
| CE22213 | |||||||||
| Other_name | cyp-1 | Person_evidence | WBPerson466 | ||||||
| CELE_Y49A3A.5 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | cyn-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 20 Sep 2004 16:20:02 | WBPerson1971 | Name_change | CGC_name | cyp-1 -> cyn-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyn | ||||||||
| Allele (25) | |||||||||
| Legacy_information | [C.elegansII] NMK. Cyclophilin family, transspliced to SL1. Partial sequence identity 83% to human CYP gene, 74% to yeast CSBY. Possible signal peptide. YAC Y14B8[WS, TP] | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (61) | |||||||||
| Paralog (18) | |||||||||
| Structured_description | Concise_description | cyn-1 encodes a functional cyclophilin that is predicted to be secreted; cyn-1 expression increases as worms progress from the L1 larval stage to the adult stage; cyn-1 shares an operon with vha-13 and thus might be a previously undescribed V-ATPase component or ancillary protein. | Paper_evidence | WBPaper00002472 | |||||
| WBPaper00015191 | |||||||||
| WBPaper00018604 | |||||||||
| WBPaper00026884 | |||||||||
| WBPaper00028773 | |||||||||
| WBPaper00028774 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Mar 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Bell's palsy; aggressive periodontitis; and gastrointestinal system cancer (multiple). Is an ortholog of human PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
| DOID:9261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| DOID:1474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| DOID:526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| DOID:12506 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||||
| Molecular_info | Corresponding_CDS | Y49A3A.5 | |||||||
| Corresponding_transcript | Y49A3A.5.1 | ||||||||
| Other_sequence (72) | |||||||||
| Associated_feature | WBsf647527 | ||||||||
| WBsf232918 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00024337 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00024336 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022703 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056993 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027813 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022704 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1016338 | ||||||||
| Expr1030543 | |||||||||
| Expr1160440 | |||||||||
| Expr2010669 | |||||||||
| Expr2028909 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (160) | |||||||||
| Interaction | WBInteraction000037116 | ||||||||
| WBInteraction000037117 | |||||||||
| WBInteraction000037118 | |||||||||
| WBInteraction000037119 | |||||||||
| WBInteraction000037120 | |||||||||
| WBInteraction000042207 | |||||||||
| WBInteraction000048832 | |||||||||
| WBInteraction000126611 | |||||||||
| WBInteraction000126617 | |||||||||
| WBInteraction000138016 | |||||||||
| WBInteraction000143127 | |||||||||
| WBInteraction000157022 | |||||||||
| WBInteraction000157057 | |||||||||
| WBInteraction000157953 | |||||||||
| WBInteraction000157964 | |||||||||
| WBInteraction000158357 | |||||||||
| WBInteraction000159052 | |||||||||
| WBInteraction000159064 | |||||||||
| WBInteraction000159070 | |||||||||
| WBInteraction000159085 | |||||||||
| WBInteraction000159131 | |||||||||
| WBInteraction000159354 | |||||||||
| WBInteraction000159470 | |||||||||
| WBInteraction000169941 | |||||||||
| WBInteraction000174500 | |||||||||
| WBInteraction000185181 | |||||||||
| WBInteraction000188561 | |||||||||
| WBInteraction000202435 | |||||||||
| WBInteraction000222956 | |||||||||
| WBInteraction000230659 | |||||||||
| WBInteraction000258913 | |||||||||
| WBInteraction000259132 | |||||||||
| WBInteraction000259157 | |||||||||
| WBInteraction000302550 | |||||||||
| WBInteraction000307275 | |||||||||
| WBInteraction000333284 | |||||||||
| WBInteraction000340712 | |||||||||
| WBInteraction000340713 | |||||||||
| WBInteraction000340858 | |||||||||
| WBInteraction000340867 | |||||||||
| WBInteraction000341116 | |||||||||
| WBInteraction000341162 | |||||||||
| WBInteraction000350708 | |||||||||
| WBInteraction000353722 | |||||||||
| WBInteraction000374211 | |||||||||
| WBInteraction000382302 | |||||||||
| WBInteraction000395417 | |||||||||
| WBInteraction000403528 | |||||||||
| WBInteraction000403681 | |||||||||
| WBInteraction000461635 | |||||||||
| WBInteraction000465380 | |||||||||
| WBInteraction000466538 | |||||||||
| WBInteraction000468933 | |||||||||
| WBInteraction000471023 | |||||||||
| WBInteraction000471517 | |||||||||
| WBInteraction000471780 | |||||||||
| WBInteraction000472202 | |||||||||
| WBInteraction000472203 | |||||||||
| WBInteraction000539114 | |||||||||
| WBInteraction000551885 | |||||||||
| WBInteraction000553988 | |||||||||
| WBInteraction000554294 | |||||||||
| WBInteraction000554601 | |||||||||
| WBInteraction000555124 | |||||||||
| WBInteraction000555879 | |||||||||
| WBInteraction000559624 | |||||||||
| WBInteraction000561988 | |||||||||
| WBInteraction000570779 | |||||||||
| WBInteraction000571561 | |||||||||
| WBInteraction000571977 | |||||||||
| WBInteraction000577523 | |||||||||
| WBInteraction000585434 | |||||||||
| WBInteraction000586318 | |||||||||
| Map_info | Map | V | Position | 6.26197 | Error | 0.005596 | |||
| Positive | Positive_clone | Y14B8 | Author_evidence | Page AM | |||||
| Y49A3 | Author_evidence | Page AM | |||||||
| Y49A3A | Inferred_automatically | From CDS | |||||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | PPIase or cyclophilin, EC 5. 2. 1. 8: | ||||||||
| [Page AM] Isolated independently by M. Hengartner and A. P. Page, Hengartner on library screening, and from mixed stage cDNA by A. P. Page using SL1, and known 3' seq from CEMSW74f. | |||||||||
| [Page AM] No cosmids have been identified (there is a gap in this region). This places this gene in the centre of chromosome V. | |||||||||
| [Page AM] Is transpliced by SL-1 | |||||||||
| Partial sequence identity 83% to human CYP gene, 74% to yeast CSBY. Possible signal peptide. | |||||||||
| PPIase or cyclophilin, EC 5.2.1.8 | |||||||||
| This gene has been renamed with approval of the CGC (cyp-1->cyn-1) | Person_evidence | WBPerson466 | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
