WormBase Tree Display for Gene: WBGene00000845
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WBGene00000845 | Evidence | Person_evidence | WBPerson170 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C02C2 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | cup-4 | Person_evidence | WBPerson170 | |||||
Sequence_name | C02C2.3 | ||||||||
Molecular_name | C02C2.3 | ||||||||
C02C2.3.1 | |||||||||
CE30416 | |||||||||
Other_name | CELE_C02C2.3 | Accession_evidence | NDB | BX284603 | |||||
Public_name | cup-4 | ||||||||
DB_info | Database | AceView | gene | 3I957 | |||||
WormQTL | gene | WBGene00000845 | |||||||
WormFlux | gene | WBGene00000845 | |||||||
NDB | locus_tag | CELE_C02C2.3 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00000845|UniProtKB=P34271 | |||||||
family | PTHR18945 | ||||||||
NCBI | gene | 176104 | |||||||
RefSeq | protein | NM_066309.6 | |||||||
SwissProt | UniProtAcc | P34271 | |||||||
UniProt_GCRP | UniProtAcc | P34271 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cup | ||||||||
Allele (34) | |||||||||
Strain | WBStrain00031661 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (31) | |||||||||
Ortholog (29) | |||||||||
Paralog (100) | |||||||||
Structured_description | Concise_description | cup-4 encodes a non-alpha ligand-gated ion channel with similarity to the nicotinic acetylcholine receptors; cup-4 is required cell autonomously for efficient fluid endocytosis in coelomocytes; cup-4 mutant animals display reduced levels of plasma membrane phosphatidylinositol 4,5-bisphosphate, suggesting that CUP-4 may regulate endocytosis via regulation of phospholipase C activity; in addition, cup-4 mutants display disorganized clathrin and RME-1 at the coelomocyte plasma membrane; CUP-4::GFP is expressed in coelomocytes where it localizes to the cytoplasm, primarily to cytoplasmic vesicles. | Paper_evidence | WBPaper00004883 | |||||
WBPaper00006324 | |||||||||
WBPaper00025238 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 01 Sep 2010 00:00:00 | ||||||||
Automated_description | Predicted to enable neurotransmitter receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and response to caloric restriction. Located in cytoplasmic vesicle membrane. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C02C2.3 | |||||||
Corresponding_transcript | C02C2.3.1 | ||||||||
Other_sequence | JO468316.1 | ||||||||
JI169898.1 | |||||||||
Oden_isotig23439 | |||||||||
Associated_feature | WBsf645364 | ||||||||
WBsf225290 | |||||||||
Experimental_info (7) | |||||||||
Map_info | Map | III | Position | -0.533135 | Error | 0.003482 | |||
Positive | Positive_clone | C02C2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
pJF148 | Person_evidence | WBPerson170 | |||||||
Mapping_data | Multi_point | 3952 | |||||||
5055 | |||||||||
Reference (13) | |||||||||
Remark | pJF148 is identified as positive via stable transformation rescue, ar494 mutation, RNAi | Person_evidence | WBPerson170 | ||||||
Method | Gene |