WormBase Tree Display for Gene: WBGene00000835
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| WBGene00000835 | SMap | S_parent | Sequence | ZK652 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cuc-1 | |||||||
| Sequence_name | ZK652.11 | ||||||||
| Molecular_name | ZK652.11 | ||||||||
| ZK652.11.1 | |||||||||
| CE29163 | |||||||||
| Other_name | CELE_ZK652.11 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | cuc-1 | ||||||||
| DB_info | Database | AceView | gene | 3I952 | |||||
| WormQTL | gene | WBGene00000835 | |||||||
| WormFlux | gene | WBGene00000835 | |||||||
| NDB | locus_tag | CELE_ZK652.11 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000835|UniProtKB=G5EE41 | |||||||
| family | PTHR46365 | ||||||||
| NCBI | gene | 176102 | |||||||
| RefSeq | protein | NM_066306.9 | |||||||
| TREEFAM | TREEFAM_ID | TF352589 | |||||||
| TrEMBL | UniProtAcc | G5EE41 | |||||||
| UniProt_GCRP | UniProtAcc | G5EE41 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cuc | ||||||||
| Allele | WBVar01500260 | ||||||||
| WBVar01499774 | |||||||||
| WBVar00402316 | |||||||||
| WBVar00841437 | |||||||||
| WBVar00250420 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (25) | |||||||||
| Structured_description | Concise_description | cuc-1 encodes a copper chaperone orthologous to Saccharomyces cerevisiae Atx1p and the vertebrate ATOX1 proteins; by homology, CUC-1 copper chaperone is predicted to function in the cytosol by transferring copper to the CUA-1 ATPase for transport into the post-Golgi compartment; when overexpressed in S. cerevisiae atx1 mutants, a cuc-1 cDNA is able to complement observed growth defects on iron-depleted media suggesting that, in vivo, CUC-1 functions in intracellular copper ion trafficking; in C. elegans, loss of cuc-1 activity via RNAi in wild-type and mutant backgrounds results in reduced fat content, suggesting that cuc-1 also plays a role in lipid metabolism; a cuc-1::GFP promoter fusion is strongly expressed in the adult intestine and highly expressed in the hypodermal cells of the head and body regions in the L1 larval stage; cuc-1::GFP expression is not seen in the intestine of dauer larvae. | Paper_evidence | WBPaper00003292 | |||||
| WBPaper00005655 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 01 Apr 2008 00:00:00 | ||||||||
| Automated_description | Enables copper chaperone activity. Involved in copper ion transport. Located in cytosol. Expressed in hyp5; hyp6; and hyp7 syncytium. Is an ortholog of human ATOX1 (antioxidant 1 copper chaperone). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | ZK652.11 | |||||||
| Corresponding_transcript | ZK652.11.1 | ||||||||
| Other_sequence (37) | |||||||||
| Associated_feature | WBsf651226 | ||||||||
| WBsf655455 | |||||||||
| WBsf227039 | |||||||||
| WBsf227040 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00028237 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00023389 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022104 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090620 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103666 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00024189 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00023904 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081181 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059611 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00024275 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr805 | ||||||||
| Expr1022480 | |||||||||
| Expr1030517 | |||||||||
| Expr1163020 | |||||||||
| Expr2010585 | |||||||||
| Expr2028825 | |||||||||
| Drives_construct | WBCnstr00013079 | ||||||||
| WBCnstr00037257 | |||||||||
| Construct_product | WBCnstr00037257 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (23) | |||||||||
| WBProcess | WBbiopr:00000096 | ||||||||
| WBbiopr:00000138 | |||||||||
| Map_info | Map | III | Position | -0.536341 | Error | 0.000762 | |||
| Positive | Positive_clone | ZK652 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00003292 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00050460 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00059785 | |||||||||
| Remark | Sequence connection from [Petcherski A] krb 02/04/05 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
