WormBase Tree Display for Gene: WBGene00000798

WBGene00000798 Evidence: Paper_evidence: WBPaper00005857
  SMap: S_parent: Sequence: C14A4
  Identity: Version: 2
    Name: CGC_name: crn-5 Person_evidence: WBPerson1606
      Sequence_name: C14A4.5
      Molecular_name: C14A4.5
        C14A4.5.1
        CE02146
      Other_name: exos-5 Person_evidence: WBPerson699
            WBPerson6229
        CELE_C14A4.5 Accession_evidence: NDB BX284602
      Public_name: crn-5
    DB_info: Database: AceView gene 2K883
        WormQTL gene WBGene00000798
        WormFlux gene WBGene00000798
        NDB locus_tag CELE_C14A4.5
        Panther gene CAEEL|WormBase=WBGene00000798|UniProtKB=G5EG59
          family PTHR11953
        NCBI gene 174634
        RefSeq protein NM_063883.4
        SwissProt UniProtAcc G5EG59
        TREEFAM TREEFAM_ID TF315920
        UniProt_GCRP UniProtAcc G5EG59
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 04 Jun 2007 15:54:19 WBPerson2970 Name_change: Other_name: exos-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: crn
    Allele (16)
    RNASeq_FPKM (74)
    GO_annotation (25)
    Contained_in_operon: CEOP2496
    Ortholog (34)
    Paralog: WBGene00000202 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007201 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: crn-5 encodes a cell death-related nuclease which is a homolog of Rrp46, an eukaryotic ribonulease component of the exosome, involved in RNA processing; crn-5 is believed to function in a large multinuclease complex, the degradeosome, whose components include the protein products of cps-6, crn-1, crn-4, cpy-13 and other non-nuclease components like wah-1, to promote apoptotic DNA degradation; crn-5 has been shown to bind DNA without detectable DNase activity but enhances the DNase activity of CRN-4, a DEDD family apoptotic DNAase and RNase. Paper_evidence: WBPaper00005857
            WBPaper00036712
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 Oct 2010 00:00:00
      Automated_description: Enables double-stranded DNA binding activity and enzyme binding activity. Involved in RNA processing and apoptotic DNA fragmentation. Part of exosome (RNase complex). Is an ortholog of human EXOSC5 (exosome component 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C14A4.5
    Corresponding_transcript: C14A4.5.1
    Other_sequence: Hbac_isotig03698
      CJC05327_1
      CGC00890_1
      CBC01241_1
      EX010442.1
    Associated_feature: WBsf989405
      WBsf222035
  Experimental_info: RNAi_result: WBRNAi00076121 Inferred_automatically: RNAi_primary
      WBRNAi00040475 Inferred_automatically: RNAi_primary
      WBRNAi00087549 Inferred_automatically: RNAi_primary
      WBRNAi00028862 Inferred_automatically: RNAi_primary
      WBRNAi00066285 Inferred_automatically: RNAi_primary
      WBRNAi00106134 Inferred_automatically: RNAi_primary
      WBRNAi00066145 Inferred_automatically: RNAi_primary
      WBRNAi00024551 Inferred_automatically: RNAi_primary
      WBRNAi00008390 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1018453
      Expr1030497
      Expr1144540
      Expr2010540
      Expr2028780
    Drives_construct: WBCnstr00037268
    Construct_product: WBCnstr00037268
    Microarray_results (22)
    Expression_cluster (85)
    Interaction (40)
    WBProcess: WBbiopr:00000014
      WBbiopr:00000103
  Map_info: Map: II Position: 3.12021 Error: 0.000298
    Positive: Positive_clone: C14A4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005857
    WBPaper00006283
    WBPaper00019408
    WBPaper00027291
    WBPaper00029254
    WBPaper00029257
    WBPaper00036712
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene