WormBase Tree Display for Gene: WBGene00000540

WBGene00000540 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C01G8
  Identity: Version: 1
    Name: CGC_name: cln-3.2
      Sequence_name: C01G8.2
      Molecular_name: C01G8.2
        C01G8.2.1
        CE07802
      Other_name: CELE_C01G8.2 Accession_evidence: NDB BX284601
      Public_name: cln-3.2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cln
    Allele (52)
    Strain: WBStrain00003317
      WBStrain00035515
      WBStrain00040680
      WBStrain00040681
      WBStrain00040682
      WBStrain00040677
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP1232
    Ortholog (40)
    Paralog: WBGene00000539 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00007586
      WBGene00000541 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Involved in determination of adult lifespan and regulation of egg-laying behavior. Predicted to be located in lysosome. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Is an ortholog of human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14503 Homo sapiens Paper_evidence: WBPaper00027030
          Accession_evidence: OMIM 204200
          Curator_confirmed: WBPerson324
          Date_last_updated: 26 Mar 2013 00:00:00
    Potential_model: DOID:0110731 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2074)
  Models_disease_asserted: WBDOannot00000119
    WBDOannot00000120
  Molecular_info: Corresponding_CDS: C01G8.2
    Corresponding_transcript: C01G8.2.1
    Other_sequence (22)
    Associated_feature: WBsf983643
      WBsf219397
      WBsf219398
  Experimental_info: RNAi_result: WBRNAi00076068 Inferred_automatically: RNAi_primary
      WBRNAi00002879 Inferred_automatically: RNAi_primary
      WBRNAi00028311 Inferred_automatically: RNAi_primary
      WBRNAi00039362 Inferred_automatically: RNAi_primary
      WBRNAi00007910 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram135
      Expr5097
      Expr1011613
      Expr1030323
      Expr1143478
      Expr2010241
      Expr2028483
    Drives_construct: WBCnstr00003788
      WBCnstr00011675
    Microarray_results (18)
    Expression_cluster: WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044736:flat_dev_expression
      WBPaper00045486:starvation_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00048923:Aging_regulated
      WBPaper00048926:miaserin_upregulated_adult-day5
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050743:elli-1(sam-3)_upregulated
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00061340:AVJ
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061527:trm-1-H43I07.2
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00025032:cluster_86
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00034739:N2lessDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_B
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_76
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction: WBInteraction000122589
      WBInteraction000133975
      WBInteraction000133976
      WBInteraction000469665
  Map_info: Map: I Position: -0.208648 Error: 0.012379
    Positive: Positive_clone: C01G8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4226
    Pseudo_map_position
  Reference: WBPaper00004972
    WBPaper00004973
    WBPaper00005520
    WBPaper00011371
    WBPaper00018531
    WBPaper00019415
    WBPaper00027030
    WBPaper00038491
    WBPaper00055090
    WBPaper00066025
  Remark: [Sara E Mole] Three C. elegans genes are equally similar to the human gene CLN3 which causes juvenile neuronal ceroid lipofuscinosis (NCL) or Batten disease. There is at least one similar gene in over 20 eukaryotic species, including S. cerevisiae, S.pombe, D. melanogaster. No other completely sequenced genome has more than one CLN3 homologue. All three cln-3 genes in C. elegans are trancribed and accession numbers have been applied for. In human there are up to 8 NCL genes named CLN-8. CLN1 also has one homologue in C. elegans. CLN1 encodes the enzyme palmitoyl protein thioesterase 1 (PPT1).
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene