Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00000536

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00000536EvidencePaper_evidenceWBPaper00013270
SMapS_parentSequenceZC395
IdentityVersion1
NameCGC_nameclk-1Person_evidenceWBPerson247
Sequence_nameZC395.2
Molecular_nameZC395.2
ZC395.2.1
CE01438
Other_namecoq-7CGC_data_submission
coq-1
CELE_ZC395.2Accession_evidenceNDBBX284603
Public_nameclk-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classclk
Allele (17)
Legacy_information[Hekimi S] Phenotype is slow growth. Strong maternal rescue of M+ Z- worms. Zygotically rescued. clk-1(qm30) worms are viable at 20C but become sterile at 25C.
[Hekimi S] e2519mat growth and behavior slowed by up to 2-fold. Profound zygotic and maternal rescue. Slow postembryonic development, slow cell cycle, long life span. Swimming, pumping, egg-laying, defecation all slow and irregular. OA4- qm30 (worms are viable at 20C but become sterile at 25C)
[C.elegansII] e2519mat : growth and behavior slowed by up to 2-fold.Profound zygotic and maternal rescue.Slow postembryonic development, slow cell cycle,long life span. Swimming, pumping, egg-laying, defecation all slow and irregular. OA4: qm30 (worms are viable at 20C but become sterile at 25C) qm11, qm47, qm51. Cloned: cosmid rescue (W03B11)[Wong et al. 1995]
Strain (11)
RNASeq_FPKM (74)
GO_annotation00046876
00046877
00046878
00046879
00046880
00046881
00046882
00046883
00046884
00046885
00046886
00046887
00046888
00046889
00046890
00046891
00046892
00046893
00046894
00046895
00046896
00046897
00046898
00046899
00046900
00046901
00046902
00046903
00046904
00046905
00046906
00046907
00046908
00046909
00046910
00046911
00046912
00046913
00046914
00046915
00046916
00046917
00046918
00046919
00046920
00046921
00046922
00046923
00046924
00046925
00046926
00046927
00046928
00046929
00046930
00046931
00046932
00046933
00046934
00046935
00046936
00046937
00046938
00046939
00046940
00107562
00107563
Contained_in_operonCEOP3280
Ortholog (34)
Structured_descriptionConcise_descriptionclk-1 encodes the C. elegans ortholog of COQ7/CAT5, a highly conserved demethoxyubiquinone (DMQ) hydroxylase that is necessary for the biosynthesis of ubiquinone (coenzyme Q, Q9) from 5-demethoxyubiquinone (DMQ9); in C. elegans, CLK-1 activity is required for normal physiological rates of growth, development, behavior, and aging, as well as for normal brood sizes.Paper_evidenceWBPaper00004595
WBPaper00006240
WBPaper00027358
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated09 Jul 2007 00:00:00
Automated_descriptionEnables transcription cis-regulatory region binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of multicellular organismal process; and regulation of macromolecule metabolic process. Located in mitochondrion and nucleus. Expressed widely. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 8. Is an ortholog of human COQ7 (coenzyme Q7, hydroxylase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070245Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2244)
EFO:MONDO:0015363Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2244)
Molecular_infoCorresponding_CDSZC395.2
Corresponding_transcriptZC395.2.1
Other_sequence (43)
Associated_feature (2)
Experimental_info (11)
Map_infoMapIIIPosition-1.84679Error0.003094
Well_ordered
PositiveInside_rearrsDp3
Positive_cloneZC395Inferred_automaticallyFrom sequence, transcript, pseudogene data
ZC400Person_evidenceWBPerson168
Mapping_data2_point7067
Multi_point2741
2744
2755
3304
3618
3621
3624
3625
Pos_neg_data8730
8731
8736
9313
Reference (306)
Remark[Ewbank J] Cloned: cosmid rescue (W03B11)" is false;ZC395 gives cosmid rescue
MethodGene