WormBase Tree Display for Gene: WBGene00000535

WBGene00000535 SMap: S_parent: Sequence: K08B4
  Identity: Version: 2
    Name: CGC_name: cpi-1 Paper_evidence: WBPaper00026724
            WBPaper00005846
            WBPaper00024997
          Person_evidence: WBPerson4368
            WBPerson390
      Sequence_name: K08B4.6
      Molecular_name: K08B4.6
        K08B4.6.1
        CE18035
      Other_name: cli-2
        CELE_K08B4.6 Accession_evidence: NDB BX284604
      Public_name: cpi-1
    DB_info: Database: AceView gene 4G858
        WormQTL gene WBGene00000535
        WormFlux gene WBGene00000535
        NDB locus_tag CELE_K08B4.6
        Panther gene CAEEL|WormBase=WBGene00000535|UniProtKB=G5EDZ9
          family PTHR46186
        NCBI gene 177372
        RefSeq protein NM_068514.6
        SwissProt UniProtAcc G5EDZ9
        UniProt_GCRP UniProtAcc G5EDZ9
        OMIM gene 601891
            604312
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 04 Jan 2006 11:25:27 WBPerson2970 Name_change: CGC_name: cpi-1
                Other_name: cli-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cpi
    Allele (20)
    Strain: WBStrain00031872
      WBStrain00054919
    RNASeq_FPKM (74)
    GO_annotation: 00015098
      00015099
      00015100
      00015101
      00015102
      00015103
      00015104
      00015105
      00015106
      00107561
    Ortholog: WBGene00027959 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00146942 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00156385 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00157656 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00162912 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00066070 Caenorhabditis remanei From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00126871 Caenorhabditis japonica From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      CSP21.g12872 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP21.g14534 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP21.g14535 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g2539 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g21091 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g21093 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g10441 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP29.g10444 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP29.g16478 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g17939 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g10224 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP32.g10225 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP32.g10226 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g4087 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g13922 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g21484 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g24276 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g10683 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00813.g14319 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_IV.g13309 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_IV.g13477 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g17338 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00562.g12910 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_20359 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_013644 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g00287 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_40160120 Caenorhabditis inopinata From_analysis: WormBase-Compara
      Sp34_40160300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      Sp34_40160400 Caenorhabditis inopinata From_analysis: WormBase-Compara
      Sp34_40160500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      Sp34_40160600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g10550 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00123065 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00118623 Pristionchus pacificus From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-030616-512 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-060810-77 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-373 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:2473 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:2474 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
      HGNC:2475 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:2476 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:2477 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
      HGNC:2478 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            PhylomeDB
      HGNC:2479 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
      HGNC:2480 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
      HGNC:15958 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            PhylomeDB
      MGI:102519 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      MGI:1298217 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            PhylomeDB
      MGI:107161 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
      MGI:1340053 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
      MGI:1930004 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
      MGI:1916544 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
      MGI:1920970 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            PhylomeDB
      MGI:1925490 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
      MGI:2652834 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
      RGD:2432 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      RGD:2434 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
      RGD:628799 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            PhylomeDB
      RGD:620589 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
      RGD:1307417 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
      RGD:735160 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      RGD:1565109 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
      RGD:1309154 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            PhylomeDB
      RGD:1310978 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
      RGD:1564873 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
      RGD:1594832 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
    Paralog: WBGene00000534 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016523 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00023486 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: cpi-1 encodes a homolog of cysteine protease inhibitors (cystatins); cpi-1 is at least superficially dispensable for viability and gross morphology. Paper_evidence: WBPaper00005654
            WBPaper00012890
          Curator_confirmed: WBPerson567
          Date_last_updated: 16 Jul 2007 00:00:00
      Automated_description: Enables cysteine-type endopeptidase inhibitor activity. Predicted to be located in cytoplasm; extracellular space; and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; CST3-related cerebral amyloid angiopathy; artery disease (multiple); and autoimmune disease of the nervous system (multiple). Is an ortholog of human CST1 (cystatin SN); CST3 (cystatin C); and CST4 (cystatin S). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (17)
  Molecular_info: Corresponding_CDS: K08B4.6
    Corresponding_transcript: K08B4.6.1
    Other_sequence (14)
    Associated_feature: WBsf651835
      WBsf230135
  Experimental_info: RNAi_result: WBRNAi00089361 Inferred_automatically: RNAi_primary
      WBRNAi00034106 Inferred_automatically: RNAi_primary
      WBRNAi00089116 Inferred_automatically: RNAi_primary
      WBRNAi00089348 Inferred_automatically: RNAi_primary
      WBRNAi00050231 Inferred_automatically: RNAi_primary
      WBRNAi00016775 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1027924
      Expr1153925
      Expr2010489
      Expr2028729
    Drives_construct: WBCnstr00037466
    Construct_product: WBCnstr00037466
    Microarray_results (16)
    Expression_cluster (307)
    Interaction (190)
  Map_info: Map: IV Position: 2.96435 Error: 0.003526
    Positive: Positive_clone: K08B4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4900
    Pseudo_map_position
  Reference (13)
  Remark: Sequence connection from [Hashmi S, Lustigan S], [krb 020711]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    cpi-1 is also an other_name of cpin-1 (WBGene000000775) Person_evidence: WBPerson531
  Method: Gene