WormBase Tree Display for Gene: WBGene00000516

WBGene00000516 SMap: S_parent: Sequence: T05A6
  Identity: Version: 1
    Name: CGC_name: cki-1 Person_evidence: WBPerson322
      Sequence_name: T05A6.1
      Molecular_name: T05A6.1
        T05A6.1.1
        CE03628
      Other_name: CELE_T05A6.1 Accession_evidence: NDB BX284602
      Public_name: cki-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cki
    Allele (11)
    Strain: WBStrain00035555
      WBStrain00050664
    RNASeq_FPKM (74)
    GO_annotation: 00074469
      00074470
      00074471
      00074472
      00074473
      00074474
      00074475
      00074476
      00074477
      00074478
      00074479
      00074480
      00074481
      00074482
      00074483
      00074484
      00074485
      00074486
      00074487
      00107507
      00107508
      00107509
    Ortholog (25)
    Paralog: WBGene00000517 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
    Structured_description: Concise_description: cki-1 encodes a homolog of the mammalian cyclin-dependent kinase inhibitor p27/KIP1 that is required for the arrest of cell division in larval blast lineages, dauer larvae and starved L1 larvae; excess CKI-1 expression prematurely stops cell division while cki-1(RNAi) induces extra cell divisions, indicating that CKI-1 quantitatively regulates the amount of mitosis in postembryonic worms. Paper_evidence: WBPaper00003201
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including gonad development; regulation of cell cycle process; and regulation of cell division. Located in nucleus. Expressed in several structures, including excretory duct; hermaphrodite somatic gonadal cell; hypodermal cell; pharynx; and somatic gonad precursor. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); lung carcinoma (multiple); and urinary system cancer (multiple). Is an ortholog of human CDKN1B (cyclin dependent kinase inhibitor 1B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (15)
  Molecular_info: Corresponding_CDS: T05A6.1
    Corresponding_transcript: T05A6.1.1
    Other_sequence: AF179358
      CJC06215_1
    Associated_feature (24)
  Experimental_info: RNAi_result (52)
    Expr_pattern (13)
    Drives_construct: WBCnstr00000933
      WBCnstr00008831
      WBCnstr00010882
      WBCnstr00012156
      WBCnstr00037482
    Construct_product: WBCnstr00000595
      WBCnstr00015480
      WBCnstr00019394
      WBCnstr00021185
      WBCnstr00037482
      WBCnstr00041722
    Antibody: WBAntibody00000980
    Microarray_results (21)
    Expression_cluster (249)
    Interaction: WBInteraction000000986
      WBInteraction000002632
      WBInteraction000003064
      WBInteraction000003193
      WBInteraction000003194
      WBInteraction000003497
      WBInteraction000003856
      WBInteraction000003963
      WBInteraction000004107
      WBInteraction000004108
      WBInteraction000004639
      WBInteraction000005077
      WBInteraction000005078
      WBInteraction000005730
      WBInteraction000005731
      WBInteraction000005732
      WBInteraction000005794
      WBInteraction000006972
      WBInteraction000008679
      WBInteraction000008800
      WBInteraction000008853
      WBInteraction000009240
      WBInteraction000009241
      WBInteraction000009687
      WBInteraction000009688
      WBInteraction000009801
      WBInteraction000028840
      WBInteraction000030025
      WBInteraction000030118
      WBInteraction000030119
      WBInteraction000052043
      WBInteraction000052733
      WBInteraction000052823
      WBInteraction000052955
      WBInteraction000126815
      WBInteraction000126816
      WBInteraction000133642
      WBInteraction000143162
      WBInteraction000151154
      WBInteraction000151162
      WBInteraction000161912
      WBInteraction000165154
      WBInteraction000165156
      WBInteraction000165557
      WBInteraction000165558
      WBInteraction000165582
      WBInteraction000165611
      WBInteraction000165844
      WBInteraction000183670
      WBInteraction000188958
      WBInteraction000196874
      WBInteraction000197103
      WBInteraction000211132
      WBInteraction000232999
      WBInteraction000284893
      WBInteraction000292910
      WBInteraction000304674
      WBInteraction000306417
      WBInteraction000323861
      WBInteraction000335251
      WBInteraction000335316
      WBInteraction000335625
      WBInteraction000338955
      WBInteraction000340031
      WBInteraction000340243
      WBInteraction000357280
      WBInteraction000366231
      WBInteraction000375744
      WBInteraction000388971
      WBInteraction000394784
      WBInteraction000399222
      WBInteraction000406630
      WBInteraction000414451
      WBInteraction000423740
      WBInteraction000426396
      WBInteraction000429314
      WBInteraction000431069
      WBInteraction000432151
      WBInteraction000440555
      WBInteraction000441807
      WBInteraction000501642
      WBInteraction000502239
      WBInteraction000502371
      WBInteraction000502731
      WBInteraction000502902
      WBInteraction000502911
      WBInteraction000503415
      WBInteraction000503416
      WBInteraction000504788
      WBInteraction000505116
      WBInteraction000505117
      WBInteraction000517293
      WBInteraction000518708
      WBInteraction000522335
      WBInteraction000534865
      WBInteraction000540206
      WBInteraction000540822
      WBInteraction000540842
      WBInteraction000544783
      WBInteraction000549461
      WBInteraction000549802
      WBInteraction000549803
      WBInteraction000556328
      WBInteraction000557564
      WBInteraction000557626
      WBInteraction000557636
      WBInteraction000558270
      WBInteraction000558271
      WBInteraction000558272
  Map_info: Map: II Position: 0.566619 Error: 0.001788
    Positive: Positive_clone: T05A6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4221
        4222
    Pseudo_map_position
  Reference (120)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene