WormBase Tree Display for Gene: WBGene00000468
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| WBGene00000468 | SMap | S_parent | Sequence | F43G9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ces-1 | Person_evidence | WBPerson268 | |||||
| Sequence_name | F43G9.11 | ||||||||
| Molecular_name | F43G9.11 | ||||||||
| F43G9.11.1 | |||||||||
| CE17821 | |||||||||
| Other_name | CELE_F43G9.11 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | ces-1 | ||||||||
| DB_info | Database | AceView | gene | 1J211 | |||||
| WormQTL | gene | WBGene00000468 | |||||||
| WormFlux | gene | WBGene00000468 | |||||||
| NDB | locus_tag | CELE_F43G9.11 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000468|UniProtKB=G5ECN8 | |||||||
| family | PTHR24409 | ||||||||
| NCBI | gene | 185718 | |||||||
| RefSeq | protein | NM_059937.3 | |||||||
| TREEFAM | TREEFAM_ID | TF315515 | |||||||
| TrEMBL | UniProtAcc | G5ECN8 | |||||||
| UniProt_GCRP | UniProtAcc | G5ECN8 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ces | ||||||||
| Allele (29) | |||||||||
| Legacy_information | [C.elegansII] n703 : sisters of NSM, I2 fail to undergo programmed cell death (gf allele). OA2 (gf): n1895, n1896 (similar).lf alleles (probable null) wild type but suppress ces-2 mutations.Cloned: encodes zinc finger protein, mostrelated to snail of Drosophila.[Ellis and Horvitz 1991; MT] | ||||||||
| [C.elegansII] n703 : sisters of NSM, I2 fail to undergo programmed cell death (gf allele). OA2 (gf): n1895, n1896 (similar).lf alleles (probable null) wild type but suppress ces-2 mutations. Cloned: encodes zinc finger protein, most related to snail of Drosophila. [Ellis and Horvitz 1991; MT] | |||||||||
| Strain (14) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (34) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | ces-1 encodes a C2H2-type zinc finger transcription factor that is a member of the Snail family of proteins that includes Drosophila Scratch, Snail, and Slug, and human SNAIL and SLUG; during development, CES-1 functions as a transcriptional repressor that blocks programmed cell death in specific neurons by inhibiting expression of the cell-death activator EGL-1; in addition, CES-1 functions to regulate asymmetric cell division and mitotic spindle orientation in the NSM lineage in which it also plays a role in regulating apoptosis; in regulating EGL-1 expression, CES-1 appears to antagonize the transcriptional activity of the bHLH proteins, HLH-2 and HLH-3; genetic studies indicate that ces-1 transcription is negatively regulated by DNJ-11 and by the bZIP transcription factor CES-2, which can bind CES-1 upstream sequences in vitro and thus may directly regulate CES-1 transcription in vivo. | Paper_evidence | WBPaper00003698 | |||||
| WBPaper00006120 | |||||||||
| WBPaper00031670 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 08 Aug 2012 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of programmed cell death and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is an ortholog of human SCRT1 (scratch family transcriptional repressor 1) and SCRT2 (scratch family transcriptional repressor 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F43G9.11 | |||||||
| Corresponding_transcript | F43G9.11.1 | ||||||||
| Other_sequence (11) | |||||||||
| Associated_feature | WBsf019219 | ||||||||
| WBsf643537 | |||||||||
| WBsf655743 | |||||||||
| WBsf656647 | |||||||||
| WBsf656648 | |||||||||
| WBsf978356 | |||||||||
| WBsf218182 | |||||||||
| Gene_product_binds (9157) | |||||||||
| Transcription_factor | WBTranscriptionFactor000057 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00047218 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00032199 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070179 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003658 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116807 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116303 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114707 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112282 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8127 | ||||||||
| Expr1024550 | |||||||||
| Expr1030272 | |||||||||
| Expr1151077 | |||||||||
| Expr1200034 | |||||||||
| Expr2009926 | |||||||||
| Expr2028166 | |||||||||
| Drives_construct | WBCnstr00000142 | ||||||||
| WBCnstr00013130 | |||||||||
| WBCnstr00037514 | |||||||||
| WBCnstr00038959 | |||||||||
| WBCnstr00038960 | |||||||||
| Construct_product | WBCnstr00000142 | ||||||||
| WBCnstr00013130 | |||||||||
| WBCnstr00019669 | |||||||||
| WBCnstr00019670 | |||||||||
| WBCnstr00037514 | |||||||||
| WBCnstr00038959 | |||||||||
| WBCnstr00038960 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (136) | |||||||||
| Interaction (150) | |||||||||
| Map_info | Map | I | Position | 3.01232 | Error | 0.001862 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C02D7 | |||||||
| F43G9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point (16) | ||||||||
| Reference (82) | |||||||||
| Method | Gene |
