WormBase Tree Display for Gene: WBGene00000448
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| WBGene00000448 | SMap | S_parent | Sequence | K12H4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | pros-1 | Paper_evidence | WBPaper00041965 | |||||
| Person_evidence | WBPerson351 | ||||||||
| Sequence_name | K12H4.1 | ||||||||
| Molecular_name | K12H4.1 | ||||||||
| K12H4.1.1 | |||||||||
| CE45017 | |||||||||
| Other_name | ceh-26 | Person_evidence | WBPerson83 | ||||||
| rdy-3 | Person_evidence | WBPerson351 | |||||||
| CELE_K12H4.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | pros-1 | ||||||||
| DB_info | Database | AceView | gene | 3J159 | |||||
| WormQTL | gene | WBGene00000448 | |||||||
| WormFlux | gene | WBGene00000448 | |||||||
| NDB | locus_tag | CELE_K12H4.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000448|UniProtKB=P34522 | |||||||
| family | PTHR12198 | ||||||||
| NCBI | gene | 176137 | |||||||
| RefSeq | protein | NM_066359.5 | |||||||
| SwissProt | UniProtAcc | P34522 | |||||||
| TREEFAM | TREEFAM_ID | TF316638 | |||||||
| UniProt_GCRP | UniProtAcc | P34522 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 08 Feb 2013 16:32:00 | WBPerson2970 | Name_change | CGC_name | pros-1 | ||||
| Other_name | ceh-26 | ||||||||
| 3 | 13 Oct 2017 10:01:31 | WBPerson2970 | Event | Acquires_merge | WBGene00004329 | ||||
| Name_change | Other_name | rdy-3 | |||||||
| Acquires_merge | WBGene00004329 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pros | ||||||||
| Allele (52) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes predicted protein (K12H4.1), with atypical homeodomain, similar to Drosophila prosperoin homeodomain and C-term 100 aa. [Burglin 1994, TB] | ||||||||
| Strain | WBStrain00034658 | ||||||||
| WBStrain00031699 | |||||||||
| WBStrain00026585 | |||||||||
| WBStrain00049273 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | pros-1 encodes a homeodomain protein that is the C. elegans homolog of Drosophila prospero and mammalian Prox1 (Prospero-related homeobox); PROS-1 is required for excretory canal growth, and loss of pros-1 function in large-scale RNAi screens has been reported to result in locomotion defects, slow growth, and larval lethality; in regulating excretory canal growth, PROS-1 functions via regulation of a number of target genes, including aqp-8, exc-5, gck-3 and ifb-1; a pros-1::gfp reporter fusion is expressed beginning at the comma stage of embryogenesis and continues through adulthood; pros-1::gfp expression is seen mainly in head and tail neurons and in the excretory cell; male-specific expression is seen in the HOB hook neuron where it is positively regulated by the EGL-46 and EGL-44 transcription factors, as well as the DAF-19 RFX transcription factor. | Paper_evidence | WBPaper00001893 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00006247 | |||||||||
| WBPaper00006395 | |||||||||
| WBPaper00029055 | |||||||||
| WBPaper00029258 | |||||||||
| WBPaper00041965 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 03 Oct 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in glial cell development. Located in nucleus. Expressed in several structures, including labial sensillum and neuronal sheath cell. Is an ortholog of human PROX1 (prospero homeobox 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K12H4.1 | |||||||
| Corresponding_transcript | K12H4.1.1 | ||||||||
| Other_sequence (22) | |||||||||
| Associated_feature (16) | |||||||||
| Gene_product_binds (5321) | |||||||||
| Transcription_factor | WBTranscriptionFactor000747 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00067990 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00068139 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00025957 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112230 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008993 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005150 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050679 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067909 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112231 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00000359 | ||||||||
| WBCnstr00012761 | |||||||||
| WBCnstr00017205 | |||||||||
| WBCnstr00037991 | |||||||||
| WBCnstr00038086 | |||||||||
| WBCnstr00038087 | |||||||||
| Construct_product | WBCnstr00000359 | ||||||||
| WBCnstr00015369 | |||||||||
| WBCnstr00016863 | |||||||||
| WBCnstr00017209 | |||||||||
| WBCnstr00037991 | |||||||||
| WBCnstr00038086 | |||||||||
| WBCnstr00038087 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (159) | |||||||||
| Interaction (95) | |||||||||
| Map_info | Map | III | Position | -0.400259 | Error | 0.006464 | |||
| Positive | Positive_clone | K12H4 | Person_evidence | WBPerson83 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Pseudo_map_position | |||||||||
| Reference (28) | |||||||||
| Remark | Map III at -0.40 | ||||||||
| Sequence From Thomas.Burglin@unibas.ch Wed Mar 7 09:49:40 2001, but the connection had already been made. [sdm 0103] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
