WormBase Tree Display for Gene: WBGene00000439

WBGene00000439 SMap: S_parent: Sequence: C13G5
  Identity: Version: 1
    Name: CGC_name: ceh-16 Person_evidence: WBPerson83
      Sequence_name: C13G5.1
      Molecular_name: C13G5.1
        C13G5.1.1
        CE37477
        C13G5.1.2
      Other_name: CELE_C13G5.1 Accession_evidence: NDB BX284603
      Public_name: ceh-16
    DB_info: Database: AceView gene 3J715
        WormQTL gene WBGene00000439
        WormFlux gene WBGene00000439
        NDB locus_tag CELE_C13G5.1
        Panther gene CAEEL|WormBase=WBGene00000439|UniProtKB=P34326
          family PTHR24341
        NCBI gene 191618
        RefSeq protein NM_001392158.1
        SwissProt UniProtAcc P34326
        TREEFAM TREEFAM_ID TF106461
        UniProt_GCRP UniProtAcc P34326
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ceh
    Allele: WBVar02141289 Inferred_automatically: From strain object: HZ620
      WBVar01952441
      WBVar00069033
      WBVar02132409
      WBVar01500260
      WBVar00100001
      WBVar00269907
      WBVar01397086
      WBVar01397087
      WBVar00088488
      WBVar00088489
      WBVar01939366
      WBVar00251603
      WBVar01447178
      WBVar01447180
      WBVar01499774
      WBVar00070634
      WBVar00066054
      WBVar01499603
      WBVar00236788
      WBVar00236789
      WBVar01629067
      WBVar00066059
      WBVar01629068
      WBVar01266408
      WBVar00066064
      WBVar01499796
      WBVar01499797
      WBVar01567016
      WBVar01409004
      WBVar02100273
      WBVar00845808
      WBVar00845809
      WBVar00845810
      WBVar00845811
      WBVar00845812
      WBVar00845813
      WBVar00845814
      WBVar00845815
      WBVar00845816
      WBVar00845817
      WBVar00845818
      WBVar00845819
      WBVar00845820
      WBVar01490073
      WBVar00845821
      WBVar00403763
      WBVar00403764
      WBVar00845822
      WBVar00845823
      WBVar00403765
      WBVar00845824
      WBVar00845825
      WBVar00845826
      WBVar01962908
      WBVar00845827
      WBVar00845828
      WBVar00845829
      WBVar00845830
      WBVar00092119
      WBVar01990255
      WBVar00069008
      WBVar00069013
      WBVar01645706
      WBVar01645707
      WBVar01952440
    Legacy_information: [C.elegansII] NMK. Encodes predicted homeoprotein, engrailed related.[Kamb et al. 1989]
      [C.elegansII] NMK. Encodes predicted homeoprotein, engrailed related. [Kamb et al. 1989]
    Strain: WBStrain00035877
      WBStrain00003898
      WBStrain00008591
      WBStrain00049293
      WBStrain00049304
      WBStrain00055072
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog: WBGene00064450 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00041370 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00141357 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00124758 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00053694 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00149365 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00222441 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g5443 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3096 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g5270 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g13723 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g3591 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g20764 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g17653 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g15376 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g29705 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g4276 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g16827 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00441.g10901 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-ceh-16 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18565 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      FL83_19360 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_008165 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12993 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g19166 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30039500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g8434 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00245266 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00205844 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00262329 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00294323 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0001269 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0000577 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-980526-40 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-980526-167 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-980526-216 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-980526-6 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:3342 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:3343 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:95389 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:95390 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1561842 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1595088 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00000462 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00007417 Caenorhabditis elegans From_analysis: TreeFam
    Structured_description: Concise_description: ceh-16 encodes a homeodomain protein orthologous to Drosophila and vertebrate Engrailed proteins involved in segment and appendage development; ceh-16 is an essential gene required for proper specification and differentiation of the lateral seam cells during embryonic development; in specifying seam cell fates, CEH-16 appears to act as a transcriptional regulator, repressing expression of the eff-1 gene required for cell fusion and inducing expression of seam cell-specific genes such as elt-5/GATA, nhr-73, and nhr-74; in addition, during post-embryonic development, ceh-16 functions to regulate the expansion division of the epidermal seam cells that occurs during the L2 larval stage; in regulating the expansion division, ceh-16 interacts genetically with apr-1, a member of the Wnt signaling pathway that encodes the C. elegans APC ortholog; a rescuing CEH-16::GFP fusion protein is first expressed in the early embryo in cells of the AB lineage; in later embryonic stages CEH-16::GFP is seen in all lateral seam cell nuclei as well as in some anterior neurons; during post-embryonic development, CEH-16::GFP is expressed in the DA1 and DD1 motor neurons. Paper_evidence: WBPaper00024903
            WBPaper00034732
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 03 Jan 2011 00:00:00
      Automated_description: Enables sequence-specific DNA binding activity. Involved in several processes, including embryonic body morphogenesis; epidermal cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including ABarpa; AIZ; hyp5; retrovesicular ganglion neurons; and seam cell. Human ortholog(s) of this gene implicated in Parkinson's disease and autistic disorder. Is an ortholog of human EN1 (engrailed homeobox 1) and EN2 (engrailed homeobox 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:14330 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3342)
      DOID:12849 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3343)
  Molecular_info: Corresponding_CDS: C13G5.1
    Corresponding_CDS_history: C13G5.1:wp131
    Corresponding_transcript: C13G5.1.1
      C13G5.1.2
    Other_sequence (18)
    Associated_feature: WBsf645428
      WBsf659322
      WBsf659323
      WBsf717952
      WBsf978805
      WBsf993415
      WBsf225446
      WBsf225447
    Gene_product_binds (362)
    Transcription_factor: WBTranscriptionFactor000541
  Experimental_info: RNAi_result (14)
    Expr_pattern (20)
    Drives_construct (13)
    Construct_product: WBCnstr00005599
      WBCnstr00005670
      WBCnstr00011405
      WBCnstr00013434
      WBCnstr00016073
      WBCnstr00016562
      WBCnstr00016869
      WBCnstr00019258
      WBCnstr00037538
    Antibody: WBAntibody00000835
    Microarray_results (21)
    Expression_cluster (113)
    Interaction (97)
    Anatomy_function: WBbtf0067
  Map_info: Map: III Position: -0.216271 Error: 0.001861
    Positive: Positive_clone: C13G5 Inferred_automatically: From sequence, transcript, pseudogene data
        CF#EN2
    Mapping_data: Multi_point: 5618
    Pseudo_map_position
  Reference (29)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene