WormBase Tree Display for Gene: WBGene00000431
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| WBGene00000431 | SMap | S_parent | Sequence | K02B12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ceh-6 | Person_evidence | WBPerson83 | |||||
| Sequence_name | K02B12.1 | ||||||||
| Molecular_name | K02B12.1 | ||||||||
| K02B12.1.1 | |||||||||
| CE28045 | |||||||||
| Other_name | CELE_K02B12.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | ceh-6 | ||||||||
| DB_info | Database | AceView | gene | 1J76 | |||||
| WormQTL | gene | WBGene00000431 | |||||||
| WormFlux | gene | WBGene00000431 | |||||||
| NDB | locus_tag | CELE_K02B12.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000431|UniProtKB=P20268 | |||||||
| family | PTHR11636 | ||||||||
| NCBI | gene | 172640 | |||||||
| RefSeq | protein | NM_059903.6 | |||||||
| SwissProt | UniProtAcc | P20268 | |||||||
| UniProt_GCRP | UniProtAcc | P20268 | |||||||
| OMIM | gene | 300039 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ceh | ||||||||
| Allele (38) | |||||||||
| Legacy_information | [Burglin TR] lethal | ||||||||
| [C.elegansII] mg60 : embryonic or L1 lethal, malformed rectum,rectal rupture at or after 2-fold stage. mg60 is 1.6 kb deletion derived from Tc1 insertion pk33. Antibody stains strong or transiently in a variety of neuronal tissues, excretory cell, rectal cells Y, K, F, B, U. Encodes homeoprotein, POU III subclass. [Burglin et al. 1989; TB] | |||||||||
| Strain | WBStrain00034653 | ||||||||
| WBStrain00036600 | |||||||||
| WBStrain00036629 | |||||||||
| WBStrain00037487 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00006818 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000441 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ceh-6 encodes a POU family homeodomain protein, homologous to human POU3F4 (OMIM:304400, mutated in conductive deafness 3); ceh-6 is required for embryonic viability, locomotion, and molting, and for regulation of ectodermal and excretory function; ceh-6 activity is also required for transdifferentiation of the Y rectal cell to the PDA neuron during larval development; CEH-6 is expressed dynamically during development and expression includes neurons, the excretory cell, and ectodermal cells; CEH-6 localizes to both the nucleus and the cytoplasm. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00004402 | |||||||||
| WBPaper00004617 | |||||||||
| WBPaper00040964 | |||||||||
| WBPaper00030881 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 04 Dec 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in transdifferentiation. Acts upstream of with a positive effect on multicellular organismal-level water homeostasis. Located in cytosol and nucleus. Expressed in body wall musculature; hyp7 syncytium; intestine; and neurons. Human ortholog(s) of this gene implicated in X-linked deafness 2. Is an ortholog of human POU3F1 (POU class 3 homeobox 1); POU3F3 (POU class 3 homeobox 3); and POU3F4 (POU class 3 homeobox 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111737 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9217) | ||||
| Molecular_info | Corresponding_CDS | K02B12.1 | |||||||
| Corresponding_CDS_history | K02B12.1:wp52 | ||||||||
| Corresponding_transcript | K02B12.1.1 | ||||||||
| Other_sequence | AF286377 | ||||||||
| CRC06041_1 | |||||||||
| PPC15352_1 | |||||||||
| CBC00981_1 | |||||||||
| JI174934.1 | |||||||||
| Tcir_isotig27799 | |||||||||
| Acan_isotig09977 | |||||||||
| Acan_isotig22106 | |||||||||
| JO468346.1 | |||||||||
| Oden_isotig19268 | |||||||||
| Associated_feature (12) | |||||||||
| Gene_product_binds (18) | |||||||||
| Transcription_factor | WBTranscriptionFactor000126 | ||||||||
| Experimental_info | RNAi_result (57) | ||||||||
| Expr_pattern | Expr862 | ||||||||
| Expr7602 | |||||||||
| Expr10478 | |||||||||
| Expr15599 | |||||||||
| Expr1012278 | |||||||||
| Expr1030244 | |||||||||
| Expr1153386 | |||||||||
| Expr1200174 | |||||||||
| Expr2009900 | |||||||||
| Expr2028140 | |||||||||
| Drives_construct | WBCnstr00012747 | ||||||||
| WBCnstr00013401 | |||||||||
| WBCnstr00037545 | |||||||||
| Construct_product | WBCnstr00007749 | ||||||||
| WBCnstr00015370 | |||||||||
| WBCnstr00037545 | |||||||||
| Antibody | WBAntibody00000354 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (139) | |||||||||
| Interaction (107) | |||||||||
| Map_info | Map | I | Position | 2.87491 | Error | 0.010124 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | dxDf1 | |||||||
| Positive_clone | K02B12 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| WWG8 | |||||||||
| Mapping_data | Multi_point | 2780 | |||||||
| 3675 | |||||||||
| 5041 | |||||||||
| Reference (44) | |||||||||
| Method | Gene |
