WormBase Tree Display for Gene: WBGene00000403

WBGene00000403 SMap: S_parent: Sequence: B0034
  Identity: Version: 2
    Name: CGC_name: casy-1 Person_evidence: WBPerson284
            WBPerson481
      Sequence_name: B0034.3
      Molecular_name (12)
      Other_name: cdh-11 Person_evidence: WBPerson698
        CELE_B0034.3 Accession_evidence: NDB BX284602
      Public_name: casy-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 05 Jan 2006 11:22:20 WBPerson2970 Name_change: CGC_name: casy-1
                Other_name: cdh-11
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: casy
    Allele (160)
    Strain: WBStrain00001795
      WBStrain00001794
      WBStrain00022694
      WBStrain00031601
      WBStrain00055675
      WBStrain00055105
      WBStrain00055673
    RNASeq_FPKM (74)
    GO_annotation (32)
    Ortholog: WBGene00053987 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00025582 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00117674 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00134895 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00191959 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00159198 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00221950 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g7661 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g14824 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g20772 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g15665 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g12463 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g17662 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g71 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP32.g74 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g5836 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g15145 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g8604 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00089.g4010 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_00089.g4011 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_11516.g23289 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-casy-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g16407 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00132.g5182 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_04444 Caenorhabditis latens From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g11925 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g14032 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20120900 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g4652 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00247105 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00266457 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00292456 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0039928 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-100921-73 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-121214-77 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1064 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070911-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:18371 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:17447 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:17448 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1929897 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1929895 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2178323 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621153 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621151 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1306458 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description: Concise_description: casy-1 encodes a type I transmembrane protein with two extracellular cadherin domains and an LG/LNS domain that is the sole C. elegans calsyntenin/alcadein ortholog; genetic studies indicate that in C. elegans casy-1 activity is required, in parallel to the insulin-like signaling pathway, for several types of learning, including salt chemotaxis learning, temperature learning, olfactory adaptation, and integration of two sensory stimuli; large-scale RNAi experiments also suggest that casy-1 plays a role in embryonic development; casy-1 expression in adult animals is able to rescue salt chemotaxis learning defects, indicating that CASY-1 function in mature animals is sufficient to effect proper chemotactic behavior; in addition, CASY-1 expression in the ASER neuron, but not other neurons, rescues salt chemotaxis learning defects, indicating the CASY-1 can act solely in this chemosensory neuron for normal salt chemotaxis learning; a casy-1::GFP promoter fusion is expressed throughout the nervous system, including the head amphid sensory neurons, with additional expression seen in the intestine and gonadal sheath cells; a CASY-1::GFP protein fusion localizes to the plasma membrane and intracellular membranes of neuronal cell bodies, with specific N-terminal fusions indicative of CASY-1 ectodomain release into the extracellular space; domain-specific rescue experiments indicate that the secreted, proteolytically processed CASY-1 extracellular domain is sufficient to rescue salt chemotaxis learning defects. Paper_evidence: WBPaper00004508
            WBPaper00025054
            WBPaper00031647
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 03 Apr 2008 00:00:00
      Automated_description: Predicted to enable several functions, including X11-like protein binding activity; amyloid-beta binding activity; and kinesin binding activity. Involved in several processes, including GABAergic synaptic transmission; olfactory learning; and positive regulation of synaptic vesicle transport. Located in several cellular components, including extracellular region; neuromuscular junction; and neuronal cell body membrane. Expressed in neurons. Is an ortholog of human CLSTN2 (calsyntenin 2) and CLSTN3 (calsyntenin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: B0034.3a
      B0034.3b
      B0034.3c
      B0034.3d
    Corresponding_transcript: B0034.3a.1
      B0034.3b.1
      B0034.3c.1
      B0034.3d.1
    Other_sequence (80)
    Associated_feature (29)
  Experimental_info: RNAi_result: WBRNAi00038664 Inferred_automatically: RNAi_primary
      WBRNAi00027950 Inferred_automatically: RNAi_primary
      WBRNAi00009558 Inferred_automatically: RNAi_primary
      WBRNAi00038665 Inferred_automatically: RNAi_primary
    Expr_pattern (17)
    Drives_construct: WBCnstr00002178
      WBCnstr00004247
      WBCnstr00006267
      WBCnstr00006270
      WBCnstr00013090
      WBCnstr00013091
      WBCnstr00013376
      WBCnstr00023001
      WBCnstr00023062
      WBCnstr00037567
    Construct_product: WBCnstr00006267
      WBCnstr00013091
      WBCnstr00018580
      WBCnstr00018581
      WBCnstr00018582
      WBCnstr00018583
      WBCnstr00019712
      WBCnstr00037567
    Microarray_results (31)
    Expression_cluster (237)
    Interaction (44)
  Map_info: Map: II Position: -0.800583 Error: 0.01344
    Positive: Positive_clone: B0034 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4194
        4440
    Pseudo_map_position
  Reference: WBPaper00004508
    WBPaper00013424
    WBPaper00018119
    WBPaper00019298
    WBPaper00025502
    WBPaper00027233
    WBPaper00031647
    WBPaper00031767
    WBPaper00031768
    WBPaper00032995
    WBPaper00034118
    WBPaper00034123
    WBPaper00034164
    WBPaper00036547
    WBPaper00037254
    WBPaper00038261
    WBPaper00038491
    WBPaper00038829
    WBPaper00043520
    WBPaper00045517
    WBPaper00052210
    WBPaper00053043
    WBPaper00053746
    WBPaper00053832
    WBPaper00055090
    WBPaper00062602
    WBPaper00064805
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene