WormBase Tree Display for Gene: WBGene00000371
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| WBGene00000371 | Evidence | Paper_evidence | WBPaper00005707 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F26E4 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | cox-5B | Person_evidence | WBPerson117 | |||||
| WBPerson7169 | |||||||||
| Sequence_name | F26E4.9 | ||||||||
| Molecular_name | F26E4.9 | ||||||||
| F26E4.9.1 | |||||||||
| CE09693 | |||||||||
| F26E4.9.2 | |||||||||
| Other_name | lpd-4 | CGC_data_submission | |||||||
| cco-1 | Person_evidence | WBPerson1157 | |||||||
| CELE_F26E4.9 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | cox-5B | ||||||||
| DB_info | Database | AceView | gene | 1K365 | |||||
| WormQTL | gene | WBGene00000371 | |||||||
| WormFlux | gene | WBGene00000371 | |||||||
| NDB | locus_tag | CELE_F26E4.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000371|UniProtKB=P90849 | |||||||
| family | PTHR10122 | ||||||||
| NCBI | gene | 172832 | |||||||
| RefSeq | protein | NM_060200.7 | |||||||
| TREEFAM | TREEFAM_ID | TF105063 | |||||||
| TrEMBL | UniProtAcc | P90849 | |||||||
| UniProt_GCRP | UniProtAcc | P90849 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 05 Sep 2017 13:25:30 | WBPerson2970 | Name_change | CGC_name | cox-5B | ||||
| Other_name | cco-1 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cox | ||||||||
| Allele (21) | |||||||||
| Component_of_genotype | WBGenotype00000141 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00049238 | ||||||||
| 00049239 | |||||||||
| 00049240 | |||||||||
| 00049241 | |||||||||
| 00049242 | |||||||||
| 00049243 | |||||||||
| 00107246 | |||||||||
| 00107247 | |||||||||
| 00107248 | |||||||||
| Contained_in_operon | CEOP1930 | ||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | cox-5b encodes the ortholog of the nuclear-encoded cytochrome c oxidase-1 subunit Vb/COX4, a component of the electron transport chain in mitochondria; knock-down of cox-5b via RNA interference in specific tissues like body wall muscle decreases life span, whereas knock-down in the nervous system and intestine increases life-span; the effects of cox-5b on life span indicate that the electron transport chain functions in a tissue-specific manner to affect the aging process, and studies show that this effect is dependent on the mitochondrial unfolded protein response. | Paper_evidence | WBPaper00037991 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 May 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable metal ion binding activity. Involved in determination of adult lifespan; lipid storage; and proton motive force-driven mitochondrial ATP synthesis. Predicted to be located in mitochondrial envelope. Predicted to be part of mitochondrial respiratory chain complex IV. Is an ortholog of human COX5B (cytochrome c oxidase subunit 5B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Modifies_disease | DOID:450 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00001305 | ||||||||
| Molecular_info | Corresponding_CDS | F26E4.9 | |||||||
| Corresponding_transcript | F26E4.9.1 | ||||||||
| F26E4.9.2 | |||||||||
| Other_sequence (85) | |||||||||
| Associated_feature | WBsf643631 | ||||||||
| WBsf981084 | |||||||||
| WBsf984809 | |||||||||
| WBsf984810 | |||||||||
| WBsf218348 | |||||||||
| WBsf218349 | |||||||||
| WBsf218350 | |||||||||
| WBsf218351 | |||||||||
| WBsf218352 | |||||||||
| Experimental_info | RNAi_result (135) | ||||||||
| Expr_pattern | Expr1011393 | ||||||||
| Expr1030199 | |||||||||
| Expr1149560 | |||||||||
| Expr2009764 | |||||||||
| Expr2028004 | |||||||||
| Drives_construct | WBCnstr00037591 | ||||||||
| Construct_product | WBCnstr00020784 | ||||||||
| WBCnstr00020785 | |||||||||
| WBCnstr00037591 | |||||||||
| Regulate_expr_cluster (15) | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction (119) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000121 | |||||||||
| Map_info | Map | I | Position | 3.90842 | Error | 0.000958 | |||
| Positive | Positive_clone | F26E4 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (41) | |||||||||
| Remark | This gene was formerly known as lpd-4 and was renamed following advice from the CGC. [krb 030512] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
