WormBase Tree Display for Gene: WBGene00000272
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| WBGene00000272 | Evidence | Person_evidence | WBPerson1133 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F56A3 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | bro-1 | Person_evidence | WBPerson334 | |||||
| Sequence_name | F56A3.5 | ||||||||
| Molecular_name | F56A3.5 | ||||||||
| F56A3.5.1 | |||||||||
| CE28461 | |||||||||
| Other_name | CELE_F56A3.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | bro-1 | ||||||||
| DB_info | Database | AceView | gene | 1F757 | |||||
| WormQTL | gene | WBGene00000272 | |||||||
| WormFlux | gene | WBGene00000272 | |||||||
| NDB | locus_tag | CELE_F56A3.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000272|UniProtKB=Q95ZL9 | |||||||
| family | PTHR10276 | ||||||||
| NCBI | gene | 172158 | |||||||
| RefSeq | protein | NM_059141.5 | |||||||
| SwissProt | UniProtAcc | Q95ZL9 | |||||||
| TREEFAM | TREEFAM_ID | TF314675 | |||||||
| UniProt_GCRP | UniProtAcc | Q95ZL9 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | bro | ||||||||
| Allele (29) | |||||||||
| Strain | WBStrain00040728 | ||||||||
| WBStrain00003561 | |||||||||
| WBStrain00008586 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (23) | |||||||||
| Structured_description | Concise_description | bro-1 encodes an ortholog of human CBFB (OMIM:121360, mutated in acute myeloid leukemia and CBFB haploinsufficiency) and Drosophila BRO/BGB; BRO-1 is required for the normal proliferation and differentiation of seam cells, alae, and male tail rays; bro-1 mutants exhibit defective seam cell division and differentiation, and males exhibit ray loss; conversely, transgenic overexpression of BRO-1 induces excess seam cell divisions at least somewhat independently of RNT-1; coexpression of both BRO-1 and RNT-1 induces full seam cell hyperplasia; rnt-1 transcription is abnormally high in bro-1 mutant larvae; BRO-1 is also required for normal structural integrity of the vulva, with bro-1 mutants showing ruptured vulvae; BRO-1 is expressed in both cytoplasm and nuclei of hypodermal seam cells (from bean-stage embryos onward), muscle cells, the uterine seam (utse) cell in late L4 larvae, some pharyngeal neurons, and male ray precursor cells, and transgenic expression of BRO-1 in seam cells alone rescues the bro-1(bp133) mutation; seam cell phenotypes of bro-1 mutants are partly suppressed by inactivation of LIN-35, FZR-1, and CKI-1, all of which inhibit progression from G1 to S phase of the cell cycle; the structural similarity of BRO-1 to CBFbeta has been confirmed by circular dichroism; BRO-1 is bound in vitro by the RUNT domains (RDs) of either RNT-1 or its human ortholog RUNX1; although BRO-1 does not itself bind DNA, it does bind to a complex of DNA with RNT-1's RD, and enhances both the strength and the specificity of RNT-1's DNA binding when it does so; BRO-1 is genetically redundant with UNC-37 and SOP-1 in specifying seam cell fate, and BRO-1's ligand RNT-1 binds UNC-37 in vitro; bro-1(bp133) and sop-1(RNAi) also show synthetic lethality. | Paper_evidence | WBPaper00006525 | |||||
| WBPaper00013466 | |||||||||
| WBPaper00028979 | |||||||||
| WBPaper00030954 | |||||||||
| WBPaper00031094 | |||||||||
| WBPaper00031155 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 07 Nov 2007 00:00:00 | ||||||||
| Automated_description | Enables transcription corepressor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nematode male tail tip morphogenesis; and positive regulation of locomotion involved in locomotory behavior. Located in nucleus. Part of core-binding activity factor complex. Expressed in hypodermis; muscle cell; pharyngeal neurons; ray precursor cell; and uterine seam cell. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia and hepatocellular carcinoma. Is an ortholog of human CBFB (core-binding factor subunit beta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0081082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1539) | ||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1539) | ||||||
| Molecular_info | Corresponding_CDS | F56A3.5 | |||||||
| Corresponding_transcript | F56A3.5.1 | ||||||||
| Associated_feature | WBsf643281 | ||||||||
| WBsf656301 | |||||||||
| WBsf656302 | |||||||||
| WBsf983616 | |||||||||
| WBsf1009778 | |||||||||
| WBsf1009779 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00048587 | Inferred_automatically | RNAi_primary | |||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00001010 | ||||||||
| WBCnstr00004013 | |||||||||
| WBCnstr00012266 | |||||||||
| WBCnstr00012388 | |||||||||
| WBCnstr00012389 | |||||||||
| WBCnstr00012970 | |||||||||
| WBCnstr00018045 | |||||||||
| WBCnstr00037613 | |||||||||
| Construct_product | WBCnstr00009613 | ||||||||
| WBCnstr00012266 | |||||||||
| WBCnstr00012388 | |||||||||
| WBCnstr00012389 | |||||||||
| WBCnstr00037613 | |||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction | WBInteraction000052769 | ||||||||
| WBInteraction000503007 | |||||||||
| WBInteraction000503353 | |||||||||
| WBInteraction000503421 | |||||||||
| WBInteraction000504514 | |||||||||
| WBInteraction000505052 | |||||||||
| WBInteraction000524654 | |||||||||
| WBInteraction000524835 | |||||||||
| WBInteraction000540813 | |||||||||
| WBInteraction000540888 | |||||||||
| Map_info | Map | I | Position | -0.301369 | Error | 0.003667 | |||
| Positive | Positive_clone | F56A3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4850 | |||||||
| 4817 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (32) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
