WormBase Tree Display for Gene: WBGene00000249

WBGene00000249 SMap: S_parent: Sequence: T27F2
  Identity: Version: 1
    Name: CGC_name: bir-1 Person_evidence: WBPerson250
      Sequence_name: T27F2.3
      Molecular_name: T27F2.3
        T27F2.3.1
        CE06521
        T27F2.3.2
      Other_name: CELE_T27F2.3 Accession_evidence: NDB BX284605
      Public_name: bir-1
    DB_info: Database: AceView gene 5M125
        WormQTL gene WBGene00000249
        WormFlux gene WBGene00000249
        NDB locus_tag CELE_T27F2.3
        Panther gene CAEEL|WormBase=WBGene00000249|UniProtKB=G5EFA2
          family PTHR46771
        NCBI gene 179597
        RefSeq protein NM_073548.10
        SwissProt UniProtAcc G5EFA2
        TREEFAM TREEFAM_ID TF316930
        UniProt_GCRP UniProtAcc G5EFA2
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: bir
    Allele (22)
    Strain: WBStrain00051386
    RNASeq_FPKM (74)
    GO_annotation (21)
    Contained_in_operon: CEOP5296
    Ortholog (34)
    Structured_description: Concise_description: bir-1 encodes a homolog of the baculoviral inhibitor-of-apoptosis (IAP) repeat (BIR) proteins (BIRPs) family; bir-1 is required for meiotic and mitotic chromosome segregation and for cytokinesis; BIR-1 localizes to meiotic and mitotic chromosomes and to the spindle midzone; BIR-1 forms a protein complex with CSC-1, ICP-1 and AIR-2. Paper_evidence: WBPaper00004303
            WBPaper00004589
            WBPaper00005872
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 04 Mar 2013 00:00:00
      Automated_description: Predicted to enable metal ion binding activity. Involved in several processes, including chromosome organization; egg-laying behavior; and inductive cell migration. Located in condensed chromosome and spindle midzone. Expressed in egg-laying apparatus; hypodermis; pharynx; rectal muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ductal carcinoma in situ; and endometrial hyperplasia. Is an ortholog of human BIRC5 (baculoviral IAP repeat containing 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050866 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:593)
      DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:593)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:593)
      DOID:2671 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:593)
      DOID:0080365 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:593)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:593)
      DOID:0060074 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:593)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:593)
      DOID:6432 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:593)
  Molecular_info: Corresponding_CDS: T27F2.3
    Corresponding_transcript: T27F2.3.1
      T27F2.3.2
    Other_sequence: CRC03813_1
      CR07657
    Associated_feature: WBsf647283
      WBsf977296
      WBsf977297
      WBsf1020480
      WBsf232532
  Experimental_info: RNAi_result (19)
    Expr_pattern (11)
    Drives_construct: WBCnstr00037630
    Construct_product: WBCnstr00037630
    Regulate_expr_cluster: WBPaper00045565:BIR-1_induced
      WBPaper00045565:BIR-1_suppressed
    Antibody: WBAntibody00000302
      WBAntibody00002920
      WBAntibody00002966
    Microarray_results (21)
    Expression_cluster (136)
    Interaction (82)
  Map_info: Map: V Position: 3.22936 Error: 0.001138
    Positive: Positive_clone: T27F2 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4169
        5515
    Pseudo_map_position
  Reference (32)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene