WormBase Tree Display for Gene: WBGene00000235
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| WBGene00000235 | Evidence | Paper_evidence | WBPaper00004269 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | B0464 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | baf-1 | Person_evidence | WBPerson346 | |||||
| Sequence_name | B0464.7 | ||||||||
| Molecular_name | B0464.7 | ||||||||
| B0464.7.1 | |||||||||
| CE26704 | |||||||||
| Other_name | 3J557 | Accession_evidence | EMBL | AF303272 | |||||
| pna-1 | Person_evidence | WBPerson561 | |||||||
| WBPerson1780 | |||||||||
| CELE_B0464.7 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | baf-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 04 Dec 2006 15:07:20 | WBPerson1847 | Event | Acquires_merge | WBGene00004065 | ||||
| Name_change | Other_name | pna-1 | |||||||
| Acquires_merge | WBGene00004065 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | baf | ||||||||
| Allele (13) | |||||||||
| Legacy_information | [Schnabel H] maternal effect embryonic lethal with abnormal pronuclear apppearance | ||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP3588 | ||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | baf-1 encodes a small, novel protein that is highly conserved amongst metazoa; BAF-1 binds double-stranded DNA nonspecifically in vitro and is essential for proper chromosome segregation, embryogenesis, and gonad development in vivo; biochemical and phenotypic analyses suggest that BAF-1 functions as an intramolecular bridge that mediates nuclear assembly and chromatin capture by the reforming nuclear envelope; by homology with mammalian BAF proteins, BAF-1 is also predicted to play a role in regulating gene expression and higher-order chromatin structure; during interphase, BAF-1 colocalizes with LMN-1/lamin to the nuclear envelope and nuclear interior; during mitosis, BAF-1 is present in a more punctate pattern, localizing near condensing chromatin and maintaining this localization through telophase; BAF-1 localization during nuclear assembly requires the activity of LMN-1/lamin, EMR-1/emerin, and LEM-2/MAN1; baf-1 mutations also exhibit hypersensitivity to DNA damage and baf-1 exhibits genetics interactions with lem-3, suggesting that these two genes function together to regulate the DNA damage response. | Paper_evidence | WBPaper00004269 | |||||
| WBPaper00005828 | |||||||||
| WBPaper00024974 | |||||||||
| WBPaper00040826 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Apr 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Involved in several processes, including chromosome segregation; embryo development; and response to X-ray. Located in condensed chromosome, centromeric region; cytoplasm; and nucleus. Used to study muscular dystrophy. Human ortholog(s) of this gene implicated in Nestor-Guillermo progeria syndrome and hepatocellular carcinoma. Is an ortholog of human BANF1 (BAF nuclear assembly factor 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9884 | Homo sapiens | Paper_evidence | WBPaper00030942 | ||||
| Accession_evidence | OMIM | 614008 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Feb 2013 00:00:00 | ||||||||
| Potential_model | DOID:0081334 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17397) | |||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17397) | ||||||
| Disease_relevance | Mutations in the human ortholog of baf-1, banf1, which encodes for the Barrier to Autointegration Factor 1 (BAF1), are found in Nestor-Guillerno progeria syndrome; Progeria syndromes are rare disorders that involve premature aging, characterized by aged appearance, growth retardation, decreased subcutaneous fat, thin limbs, and stiff joints; in vertebrates, BAF links nuclear lamina LEM domain proteins, like Emerin and LEM2, with DNA and heterochromatin; studies in elegans have discovered that BAF1 is required for viability, stable chromosome segregation, proper localization of emr-1/emerin and LEM2 at the nuclear periphery and together with emerin and lmn-1/lamin is required for nuclear membrane reassembly at the end of mitosis; BAF, in addition to be being regulated by the different complexes it forms with different LEM domain proteins is also regulated by cell-cycle dependent phosphorylation in elegans and mammals. | Homo sapiens | Paper_evidence | WBPaper00040268 | |||||
| Accession_evidence | OMIM | 614008 | |||||||
| 603811 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Mar 2012 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000046 | ||||||||
| Molecular_info | Corresponding_CDS | B0464.7 | |||||||
| Corresponding_CDS_history | B0464.7:wp40 | ||||||||
| Corresponding_transcript | B0464.7.1 | ||||||||
| Other_sequence (50) | |||||||||
| Associated_feature | WBsf645489 | ||||||||
| WBsf645490 | |||||||||
| WBsf659408 | |||||||||
| WBsf976279 | |||||||||
| WBsf976280 | |||||||||
| WBsf976281 | |||||||||
| WBsf976282 | |||||||||
| WBsf976283 | |||||||||
| WBsf225571 | |||||||||
| WBsf225572 | |||||||||
| Experimental_info | RNAi_result (29) | ||||||||
| Expr_pattern | Expr3213 | ||||||||
| Expr4385 | |||||||||
| Expr7803 | |||||||||
| Expr1013669 | |||||||||
| Expr1030149 | |||||||||
| Expr1143252 | |||||||||
| Expr2009526 | |||||||||
| Expr2027763 | |||||||||
| Drives_construct | WBCnstr00004961 | ||||||||
| WBCnstr00004962 | |||||||||
| WBCnstr00004963 | |||||||||
| WBCnstr00006041 | |||||||||
| WBCnstr00008748 | |||||||||
| WBCnstr00008749 | |||||||||
| WBCnstr00009178 | |||||||||
| WBCnstr00009179 | |||||||||
| WBCnstr00037641 | |||||||||
| Construct_product | WBCnstr00004961 | ||||||||
| WBCnstr00004962 | |||||||||
| WBCnstr00004963 | |||||||||
| WBCnstr00011958 | |||||||||
| WBCnstr00037641 | |||||||||
| Antibody | WBAntibody00000919 | ||||||||
| WBAntibody00000920 | |||||||||
| WBAntibody00000921 | |||||||||
| WBAntibody00001196 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (115) | |||||||||
| Map_info | Map | III | Position | 0.562218 | Error | 0.005745 | |||
| Positive | Positive_clone | B0464 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5000 | |||||||
| 5288 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (24) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
