WormBase Tree Display for Gene: WBGene00000212
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| WBGene00000212 | Evidence | Paper_evidence | WBPaper00003086 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | ZK455 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | asm-2 | Person_evidence | WBPerson250 | |||||
| Sequence_name | ZK455.4 | ||||||||
| Molecular_name | ZK455.4 | ||||||||
| ZK455.4.1 | |||||||||
| CE31674 | |||||||||
| Other_name | CELE_ZK455.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | asm-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | asm | ||||||||
| Allele (50) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00000211 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000213 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00014106 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | asm-2 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase 1; the ASM-2 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-2 shows phosphodiesterase activity when expressed in COS-7 cells; like mammalian ASM, asm-2 is probably both intracellular and secreted; northern blot analysis indicates that asm-2 is expressed during post-embryonic development as compared to asm-1 which is expressed at higher levels in the embryo; human ASM is implicated in Niemann-Pick disease type B (OMIM:607608). | Paper_evidence | WBPaper00003086 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Aug 2006 00:00:00 | ||||||||
| Automated_description | Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process and sphingomyelin catabolic process. Located in extracellular region. Human ortholog(s) of this gene implicated in Niemann-Pick disease type A and Niemann-Pick disease type B. Is an ortholog of human SMPD1 (sphingomyelin phosphodiesterase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:14504 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||
| DOID:0070112 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||||
| DOID:0070111 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||||
| Molecular_info | Corresponding_CDS | ZK455.4 | |||||||
| Corresponding_CDS_history | ZK455.4:wp83 | ||||||||
| Corresponding_transcript | ZK455.4.1 | ||||||||
| Other_sequence (32) | |||||||||
| Associated_feature | WBsf654409 | ||||||||
| WBsf237956 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00038298 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00059434 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000331 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1013294 | ||||||||
| Expr1162861 | |||||||||
| Expr2009455 | |||||||||
| Expr2027692 | |||||||||
| Drives_construct | WBCnstr00037660 | ||||||||
| Construct_product | WBCnstr00037660 | ||||||||
| Antibody | WBAntibody00001822 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (207) | |||||||||
| Interaction | WBInteraction000133965 | ||||||||
| WBInteraction000177307 | |||||||||
| WBInteraction000290792 | |||||||||
| Map_info | Map | X | Position | 2.95988 | Error | 0.006229 | |||
| Positive | Positive_clone | ZK455 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
