WormBase Tree Display for Gene: WBGene00000211
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| WBGene00000211 | Evidence | Paper_evidence | WBPaper00003086 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | B0252 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | asm-1 | Person_evidence | WBPerson250 | |||||
| Sequence_name | B0252.2 | ||||||||
| Molecular_name | B0252.2 | ||||||||
| B0252.2.1 | |||||||||
| CE30230 | |||||||||
| Other_name | CELE_B0252.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | asm-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | asm | ||||||||
| Allele (27) | |||||||||
| Strain | WBStrain00001217 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000212 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00014106 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000213 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | asm-1 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase; the ASM-1 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-1 shows phosphodiesterase activity when expressed in COS-7 cells; while mammalian ASM is detected as both intracellular and secreted forms, asm-1 was detected exclusively in the secreted form; northern blot analysis indicates that asm-1 is expressed at higher levels in the embryo compared with other stages. | Paper_evidence | WBPaper00003086 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Aug 2006 00:00:00 | ||||||||
| Automated_description | Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process and sphingomyelin catabolic process. Located in extracellular region and lysosome. Human ortholog(s) of this gene implicated in Niemann-Pick disease type A and Niemann-Pick disease type B. Is an ortholog of human SMPD1 (sphingomyelin phosphodiesterase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:14504 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||
| DOID:0070112 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||||
| DOID:0070111 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||||
| Molecular_info | Corresponding_CDS | B0252.2 | |||||||
| Corresponding_transcript | B0252.2.1 | ||||||||
| Other_sequence (13) | |||||||||
| Associated_feature | WBsf1012454 | ||||||||
| WBsf221524 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00038811 | Inferred_automatically | RNAi_primary | |||||
| Expr_pattern | Chronogram2039 | ||||||||
| Expr5031 | |||||||||
| Expr1016463 | |||||||||
| Expr1030130 | |||||||||
| Expr1143014 | |||||||||
| Expr2009454 | |||||||||
| Expr2027691 | |||||||||
| Drives_construct | WBCnstr00002110 | ||||||||
| WBCnstr00007576 | |||||||||
| WBCnstr00037661 | |||||||||
| Construct_product | WBCnstr00007576 | ||||||||
| WBCnstr00037661 | |||||||||
| Antibody | WBAntibody00001822 | ||||||||
| Microarray_results | SMD_B0252.2 | ||||||||
| 192104_at | |||||||||
| A_12_P104109 | |||||||||
| Aff_B0252.2 | |||||||||
| GPL13394_WBGene00000211 | |||||||||
| GPL13914_B0252.2 | |||||||||
| GPL14144_B0252.2_1135-1194_0.901_21_C | |||||||||
| GPL14144_B0252.2_1249-1308_0.929_12_B | |||||||||
| GPL14144_B0252.2_1618-1677_0.957_1_A | |||||||||
| GPL19516_CGZ0000490 | |||||||||
| GPL21109_B0252.2 | |||||||||
| GPL3518_CE30230 | |||||||||
| GPL8304_CE_WBGene00000211_A | |||||||||
| GPL8304_CE_WBGene00000211_B | |||||||||
| GPL8304_CE_WBGene00000211_C | |||||||||
| GPL8673_B0252_2P00201 | |||||||||
| GPL8673_B0252_2P00840 | |||||||||
| GPL8673_B0252_2P01269 | |||||||||
| GPL9450_B0252.2 | |||||||||
| cea2.p.28066 | |||||||||
| Expression_cluster (145) | |||||||||
| Interaction | WBInteraction000133965 | ||||||||
| WBInteraction000255751 | |||||||||
| WBInteraction000428006 | |||||||||
| Map_info | Map | II | Position | 0.139055 | Error | 0.001453 | |||
| Positive | Positive_clone | B0252 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
