WormBase Tree Display for Gene: WBGene00000204
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| WBGene00000204 | Evidence | Paper_evidence | WBPaper00005843 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C35D10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | arx-6 | Person_evidence | WBPerson633 | |||||
| Sequence_name | C35D10.16 | ||||||||
| Molecular_name | C35D10.16 | ||||||||
| C35D10.16.1 | |||||||||
| CE28899 | |||||||||
| Other_name | CELE_C35D10.16 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | arx-6 | ||||||||
| DB_info | Database | AceView | gene | 3F969 | |||||
| WormQTL | gene | WBGene00000204 | |||||||
| WormFlux | gene | WBGene00000204 | |||||||
| NDB | locus_tag | CELE_C35D10.16 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000204|UniProtKB=P58798 | |||||||
| family | PTHR22629 | ||||||||
| NCBI | gene | 175650 | |||||||
| RefSeq | protein | NM_065619.7 | |||||||
| SwissProt | UniProtAcc | P58798 | |||||||
| TREEFAM | TREEFAM_ID | TF105621 | |||||||
| UniProt_GCRP | UniProtAcc | P58798 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | arx | ||||||||
| Allele | WBVar00824394 | ||||||||
| WBVar00824395 | |||||||||
| WBVar00824396 | |||||||||
| WBVar00824397 | |||||||||
| WBVar00824398 | |||||||||
| WBVar00824399 | |||||||||
| WBVar00052421 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Contained_in_operon | CEOP3228 | ||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | arx-6 also called as p20Arc p21Arc encodes a subunit of the actin related protein of the conserved Arp2/3 complex, with 60% amino acid similarity with the homologous genes from human (OMIM:604226); arx-6 is an essential gene as disruption in the expression by RNAi results in embryonic arrest due to ventral enclosure during morphogenesis; Arp2/3 depletion results in partial shrinking of the Ea/p apical surfaces and incomplete Ea/p cell internalization; WSP-1 activates Arp2/3 complex and their function in ventral enclosure is cell autonomous; Arp2/3 regulates some Apical Junction components in embryos and adults; Arp2/3 is required during intestinal morphogenesis for regulation of intestinal lumen width in embryos and apical F-actin accumulation during larval and adult growth. | Paper_evidence | WBPaper00005843 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 10 Aug 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity. Involved in epithelial cell migration and morphogenesis of embryonic epithelium. Predicted to be located in actin cytoskeleton and cytoplasm. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in Down syndrome. Is an ortholog of human ARPC4 (actin related protein 2/3 complex subunit 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:14250 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:707) | ||||
| Molecular_info | Corresponding_CDS | C35D10.16 | |||||||
| Corresponding_transcript | C35D10.16.1 | ||||||||
| Other_sequence (44) | |||||||||
| Associated_feature | WBsf645130 | ||||||||
| WBsf224819 | |||||||||
| WBsf224820 | |||||||||
| WBsf224821 | |||||||||
| WBsf224822 | |||||||||
| Transcription_factor | WBTranscriptionFactor000417 | ||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Chronogram620 | ||||||||
| Expr1010875 | |||||||||
| Expr1030123 | |||||||||
| Expr1145992 | |||||||||
| Expr2009439 | |||||||||
| Expr2027676 | |||||||||
| Drives_construct | WBCnstr00002865 | ||||||||
| WBCnstr00037666 | |||||||||
| Construct_product | WBCnstr00037666 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (90) | |||||||||
| Interaction (29) | |||||||||
| Map_info | Map | III | Position | -2.41157 | Error | 0.000732 | |||
| Positive | Positive_clone | C35D10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005843 | ||||||||
| WBPaper00027309 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Sequence connection was previously incorrectly assigned to the adjacent ORF .1a and .1b [krb 030623] | Person_evidence | WBPerson651 | ||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
