WormBase Tree Display for Gene: WBGene00000203

WBGene00000203 Evidence: Paper_evidence: WBPaper00005843
  SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 1
    Name: CGC_name: arx-5 Person_evidence: WBPerson633
      Sequence_name: Y37D8A.1
      Molecular_name: Y37D8A.1
        Y37D8A.1.1
        CE20206
      Other_name: CELE_Y37D8A.1 Accession_evidence: NDB BX284603
      Public_name: arx-5
    DB_info: Database: AceView gene 3N906
        WormQTL gene WBGene00000203
        WormFlux gene WBGene00000203
        NDB locus_tag CELE_Y37D8A.1
        Panther gene CAEEL|WormBase=WBGene00000203|UniProtKB=Q9XWV3
          family PTHR12391
        NCBI gene 176697
        RefSeq protein NM_067266.4
        SwissProt UniProtAcc Q9XWV3
        TREEFAM TREEFAM_ID TF314598
        UniProt_GCRP UniProtAcc Q9XWV3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: arx
    Allele (16)
    Strain: WBStrain00037079
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog: WBGene00055308 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00035891 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00159691 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00154402 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00134751 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00035246 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00226639 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g5004 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g14921 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g838 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g1831 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g8160 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g286 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g5915 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g7227 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g17694 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g4937 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00030.g1742 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_III.g8664 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_X.g24469 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18013 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00930.g16858 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_21254 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_010884 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g13002 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g10593 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30291020 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g9242 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00245723 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00091908 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00260354 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00293781 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000004362 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0065032 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0038369 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040625-107 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:706 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1928375 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1311985 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description: Concise_description: arx-5 also called as p21Arc encodes a subunit of the actin related protein of the conserved Arp2/3 complex, with 60% amino acid similarity with the homologous genes from human (OMIM: 604225); arx-5 is an essential gene as disruption in the expression by RNAi results in embryonic arrest due to ventral enclosure during morphogenesis; Arp2/3 depletion results in partial shrinking of the Ea/p apical surfaces and incomplete Ea/p cell internalization; WSP-1 activates Arp2/3 complex and their function in ventral enclosure is cell autonomous; Arp2/3 regulates some Apical Junction components in embryos and adults; Arp2/3 is required during intestinal morphogenesis for regulation of intestinal lumen width in embryos and apical F-actin accumulation during larval and adult growth. Paper_evidence: WBPaper00005843
            WBPaper00035433
          Curator_confirmed: WBPerson12884
            WBPerson1843
          Date_last_updated: 10 Aug 2011 00:00:00
      Automated_description: Predicted to enable actin binding activity. Predicted to contribute to actin filament binding activity. Involved in epithelial cell migration and morphogenesis of embryonic epithelium. Located in striated muscle dense body. Human ortholog(s) of this gene implicated in diabetes mellitus. Is an ortholog of human ARPC3 (actin related protein 2/3 complex subunit 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9351 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:706)
  Molecular_info: Corresponding_CDS: Y37D8A.1
    Corresponding_transcript: Y37D8A.1.1
    Other_sequence (39)
    Associated_feature: WBsf227685
      WBsf227686
  Experimental_info: RNAi_result (25)
    Expr_pattern: Expr8838
      Expr9399
      Expr1018806
      Expr1030122
      Expr1159393
      Expr2009438
      Expr2027675
    Drives_construct: WBCnstr00037667
    Construct_product: WBCnstr00013964
      WBCnstr00019218
      WBCnstr00037667
    Antibody: WBAntibody00002051
    Microarray_results (19)
    Expression_cluster (79)
    Interaction (43)
  Map_info: Map: III Position: 19.0426 Error: 0.030817
    Positive: Positive_clone: Y37D8A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005843
    WBPaper00024200
    WBPaper00031805
    WBPaper00035433
    WBPaper00038444
    WBPaper00038491
    WBPaper00046168
    WBPaper00055090
    WBPaper00058387
    WBPaper00063976
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene