WormBase Tree Display for Gene: WBGene00000195
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| WBGene00000195 | SMap | S_parent | Sequence | F53H8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | arr-1 | |||||||
| Sequence_name | F53H8.2 | ||||||||
| Molecular_name | F53H8.2 | ||||||||
| F53H8.2.1 | |||||||||
| CE28831 | |||||||||
| Other_name | CELE_F53H8.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | arr-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | arr | ||||||||
| Allele (60) | |||||||||
| Strain | WBStrain00031400 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00047486 | ||||||||
| 00047487 | |||||||||
| 00047488 | |||||||||
| 00047489 | |||||||||
| 00047490 | |||||||||
| 00047491 | |||||||||
| 00047492 | |||||||||
| 00047493 | |||||||||
| 00106977 | |||||||||
| Ortholog (47) | |||||||||
| Structured_description | Concise_description | arr-1 encodes the C. elegans beta-arrestin ortholog (OMIM:107940, 107941, mice lacking beta-arrestin family members display defects in G protein-coupled receptor desensitization); by homology, ARR-1 is predicted to be a multifunctional adaptor protein that interacts with intracellular signaling molecules as well as activated and phosphorylated G protein-coupled and TGF-beta receptors to: 1) downregulate receptor signaling, 2) promote receptor endocytosis, and 3) activate MAP kinase- and Src-dependent signaling pathways; in vivo, arr-1 activity is required for normal egg laying and for proper olfactory adaptation and recovery to volatile odorants; in addition, animals doubly mutant for arr-1 and grk-2, which encodes a G protein-coupled receptor kinase, are sick and slow growing; ARR-1 is detected throughout the nervous system and is highly expressed in the amphid chemosensory neurons; in neuronal cells, ARR-1 appears to be largely cytoplasmic; ARR-1 interacts physically with clathrin and beta2-adaptin, two proteins involved in receptor endocytosis. | Paper_evidence | WBPaper00005520 | |||||
| WBPaper00013467 | |||||||||
| WBPaper00025173 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 25 Jun 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable G protein-coupled receptor binding activity. Involved in positive regulation of growth rate. Predicted to be located in cytoplasm. Expressed in HSN; amphid neurons; somatic nervous system; and tail. Human ortholog(s) of this gene implicated in eye disease (multiple); major depressive disorder; and portal hypertension. Is an ortholog of human ARRB1 (arrestin beta 1) and ARRB2 (arrestin beta 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (12) | ||||||||
| Molecular_info | Corresponding_CDS | F53H8.2 | |||||||
| Corresponding_transcript | F53H8.2.1 | ||||||||
| Other_sequence (23) | |||||||||
| Associated_feature | WBsf647807 | ||||||||
| WBsf662449 | |||||||||
| WBsf662450 | |||||||||
| WBsf1003900 | |||||||||
| WBsf1003901 | |||||||||
| WBsf1003902 | |||||||||
| WBsf1003903 | |||||||||
| WBsf235298 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr4299 | ||||||||
| Expr6162 | |||||||||
| Expr6163 | |||||||||
| Expr8610 | |||||||||
| Expr8611 | |||||||||
| Expr1015865 | |||||||||
| Expr1030114 | |||||||||
| Expr1152011 | |||||||||
| Expr2009408 | |||||||||
| Expr2027644 | |||||||||
| Drives_construct | WBCnstr00002995 | ||||||||
| WBCnstr00004493 | |||||||||
| WBCnstr00011896 | |||||||||
| WBCnstr00013399 | |||||||||
| WBCnstr00037671 | |||||||||
| WBCnstr00038325 | |||||||||
| Construct_product | WBCnstr00013399 | ||||||||
| WBCnstr00037671 | |||||||||
| WBCnstr00038320 | |||||||||
| WBCnstr00038321 | |||||||||
| WBCnstr00038322 | |||||||||
| WBCnstr00038323 | |||||||||
| WBCnstr00038324 | |||||||||
| WBCnstr00038325 | |||||||||
| Antibody | WBAntibody00001658 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (120) | |||||||||
| Interaction | WBInteraction000037595 | ||||||||
| WBInteraction000047672 | |||||||||
| WBInteraction000116183 | |||||||||
| WBInteraction000142057 | |||||||||
| WBInteraction000144306 | |||||||||
| WBInteraction000147308 | |||||||||
| WBInteraction000148151 | |||||||||
| WBInteraction000150584 | |||||||||
| WBInteraction000150585 | |||||||||
| WBInteraction000150964 | |||||||||
| WBInteraction000150968 | |||||||||
| WBInteraction000152376 | |||||||||
| WBInteraction000152471 | |||||||||
| WBInteraction000157877 | |||||||||
| WBInteraction000159913 | |||||||||
| WBInteraction000159916 | |||||||||
| WBInteraction000160918 | |||||||||
| WBInteraction000162238 | |||||||||
| WBInteraction000162239 | |||||||||
| WBInteraction000162893 | |||||||||
| WBInteraction000164213 | |||||||||
| WBInteraction000164229 | |||||||||
| WBInteraction000166943 | |||||||||
| WBInteraction000167000 | |||||||||
| WBInteraction000170003 | |||||||||
| WBInteraction000172891 | |||||||||
| WBInteraction000173419 | |||||||||
| WBInteraction000173536 | |||||||||
| WBInteraction000240460 | |||||||||
| WBInteraction000264899 | |||||||||
| WBInteraction000288354 | |||||||||
| WBInteraction000304074 | |||||||||
| WBInteraction000327931 | |||||||||
| WBInteraction000331790 | |||||||||
| WBInteraction000336534 | |||||||||
| WBInteraction000339635 | |||||||||
| WBInteraction000339636 | |||||||||
| WBInteraction000339858 | |||||||||
| WBInteraction000397860 | |||||||||
| WBInteraction000431390 | |||||||||
| WBInteraction000448844 | |||||||||
| WBInteraction000519007 | |||||||||
| WBInteraction000519008 | |||||||||
| WBInteraction000519009 | |||||||||
| WBInteraction000519010 | |||||||||
| WBInteraction000519011 | |||||||||
| WBInteraction000536784 | |||||||||
| WBInteraction000536785 | |||||||||
| WBInteraction000536786 | |||||||||
| WBInteraction000536787 | |||||||||
| WBInteraction000541237 | |||||||||
| WBInteraction000541250 | |||||||||
| Anatomy_function (11) | |||||||||
| Map_info | Map | X | Position | -18.9097 | Error | 0.005023 | |||
| Positive | Positive_clone | F53H8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4163 | |||||||
| Pseudo_map_position | |||||||||
| Reference (25) | |||||||||
| Remark | Sequence connection from [Palmitessa A, Benovic J.], 02/06/12 krb. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
