WormBase Tree Display for Gene: WBGene00000168
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| WBGene00000168 | SMap | S_parent | Sequence | K08D9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | apx-1 | Person_evidence | WBPerson498 | |||||
| Sequence_name | K08D9.3 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_K08D9.3 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | apx-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | apx | ||||||||
| Allele (387) | |||||||||
| Legacy_information | [C.elegansII] or3mat : maternal effect lethal, extraanterior pharyngeal cells,ABp fails to produce intestinal valve cells.OA1: zu183.Cloned: predicted protein with similarity to Delta, Serrate, LAG-2. Can substitute for lag-2 , if fused to lag-2 promoter. [Mello et al. 1994; Gao and Kimble 1995; JJ; BB; JK; GS] | ||||||||
| Strain | WBStrain00022475 | ||||||||
| WBStrain00007259 | |||||||||
| WBStrain00007261 | |||||||||
| WBStrain00007256 | |||||||||
| WBStrain00049597 | |||||||||
| WBStrain00049520 | |||||||||
| WBStrain00049717 | |||||||||
| WBStrain00054811 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (17) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | apx-1 encodes one of ten C. elegans DSL (Delta, Serrate, LAG-2) proteins, integral transmembrane and secreted proteins that function as signaling ligands for the Notch family receptors GLP-1 and LIN-12; in the 4-cell embryo, maternally supplied APX-1 functions as a GLP-1 ligand for an inductive interaction that specifies the fate of the ABp blastomere; later in embryogenesis, APX-1 is required for formation of the LIN-12-dependent, invariant asymmetrical twist that occurs as part of normal gut morphogenesis; during larval development, APX-1 is required redundantly with DSL-1 and LAG-2 for the LIN-12-mediated lateral signal that spatially patterns the primary and secondary vulval cell lineages; in the early embryo, APX-1 is first detected at the anterior edge of the P1 blastomere, with later expression visible in P2 at sites of contact with ABp, and in the cytoplasm of the EMS and P3 blastomeres; expression in the vulval precursor cells (VPCs) is detected in the primary VPC, P6.p, and its descendants; embryonic APX-1 expression is dependent upon PIE-1 activity, while later vulval expression is mediated by the Ras signaling pathway and the SUR-2 transcriptional cofactor. | Paper_evidence | WBPaper00001930 | |||||
| WBPaper00002012 | |||||||||
| WBPaper00002479 | |||||||||
| WBPaper00004315 | |||||||||
| WBPaper00006450 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 17 Jun 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable Notch binding activity. Involved in several processes, including lateral inhibition; regulation of germ cell proliferation; and regulation of vulval development. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Expressed in several structures, including P6.paa; P6.pap; P6.ppa; non-striated muscle; and vulva. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 1. Is an ortholog of human DLL3 (delta like canonical Notch ligand 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112365 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2909) | ||||
| DOID:1934 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2909) | ||||||
| Molecular_info | Corresponding_CDS | K08D9.3a | |||||||
| K08D9.3e | |||||||||
| K08D9.3f | |||||||||
| Corresponding_transcript | K08D9.3b | ||||||||
| K08D9.3c | |||||||||
| K08D9.3d | |||||||||
| K08D9.3a.1 | |||||||||
| K08D9.3e.1 | |||||||||
| K08D9.3f.1 | |||||||||
| Other_sequence (90) | |||||||||
| Associated_feature | WBsf661047 | ||||||||
| WBsf661173 | |||||||||
| WBsf661174 | |||||||||
| WBsf977394 | |||||||||
| WBsf977395 | |||||||||
| WBsf977396 | |||||||||
| WBsf977397 | |||||||||
| WBsf977398 | |||||||||
| WBsf231554 | |||||||||
| Experimental_info | RNAi_result (40) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00000061 | ||||||||
| WBCnstr00000062 | |||||||||
| WBCnstr00001905 | |||||||||
| WBCnstr00006544 | |||||||||
| WBCnstr00007161 | |||||||||
| WBCnstr00007597 | |||||||||
| WBCnstr00013466 | |||||||||
| Antibody | WBAntibody00000111 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (156) | |||||||||
| Interaction (60) | |||||||||
| Anatomy_function | WBbtf0593 | ||||||||
| WBbtf0594 | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| WBbiopr:00000072 | |||||||||
| Map_info | Map | V | Position | -12.5303 | Error | 0.036189 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C40A5 | |||||||
| K08D9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 2820 | |||||||
| 2821 | |||||||||
| 2822 | |||||||||
| 4924 | |||||||||
| Pos_neg_data (11) | |||||||||
| Reference (110) | |||||||||
| Method | Gene |
