| WBGene00000099 | SMap | S_parent | Sequence | B0207 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | air-2 | Person_evidence | WBPerson205 |
| | | Sequence_name | B0207.4 |
| | | Molecular_name | B0207.4 |
| | | | B0207.4.1 |
| | | | CE24761 |
| | | | B0207.4.2 |
| | | Other_name | let-603 |
| | | | stu-7 |
| | | | cyk-6 |
| | | | CELE_B0207.4 | Accession_evidence | NDB | BX284601 |
| | | Public_name | air-2 |
| | DB_info | Database (14) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | air |
| | Allele (19) |
| | Legacy_information | [Hodgkin JA] e2631 hermaphrodites are long, uncoordinated and sterile, usually with a conspicuous constriction in the mid-region of the body. Males grow poorly, male tail very abnormal, ME0. |
| | | [McDowall JS] Sterile adult |
| | | [C.elegansII] h289 : sterile adult (gonad tumorous mass). OA3: h408, h437, h812 (sterile adults). Cloned: partial cosmid rescue (C32E7); rescued to Mel. [KR] |
| | | [Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C. cytokinesis defects |
| | Strain | WBStrain00023752 |
| | | WBStrain00035642 |
| | | WBStrain00004633 |
| | | WBStrain00007296 |
| | | WBStrain00007300 |
| | | WBStrain00034749 |
| | | WBStrain00051600 |
| | | WBStrain00051601 |
| | RNASeq_FPKM (74) |
| | GO_annotation (65) |
| | Ortholog | WBGene00066584 | Caenorhabditis remanei | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00026778 | Caenorhabditis briggsae | From_analysis | Hillier-set |
| | | | | | OrthoMCL |
| | | | | | OMA |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00153601 | Caenorhabditis brenneri | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00176308 | Caenorhabditis japonica | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | WBGene00128903 | Caenorhabditis japonica | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00193267 | Caenorhabditis brenneri | From_analysis | WormBase-Compara |
| | | WBGene00221969 | Brugia malayi | From_analysis | WormBase-Compara |
| | | CBOVI.g12058 | Caenorhabditis bovis | From_analysis | WormBase-Compara |
| | | CBOVI.g7587 | Caenorhabditis bovis | From_analysis | WormBase-Compara |
| | | CSP21.g3121 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP26.g2039 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara |
| | | CSP28.g3765 | Caenorhabditis panamensis | From_analysis | WormBase-Compara |
| | | CSP29.g11150 | Caenorhabditis becei | From_analysis | WormBase-Compara |
| | | CSP31.g22561 | Caenorhabditis uteleia | From_analysis | WormBase-Compara |
| | | CSP31.g535 | Caenorhabditis uteleia | From_analysis | WormBase-Compara |
| | | CSP38.g21074 | Caenorhabditis quiockensis | From_analysis | WormBase-Compara |
| | | CSP39.g18609 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara |
| | | CSP40.g17012 | Caenorhabditis tribulationis | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_00204.g6948 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Cni-air-2 | Caenorhabditis nigoni | From_analysis | WormBase-Compara |
| | | Csp11.Scaffold630.g17083 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara |
| | | Csp5_scaffold_01534.g21540 | Caenorhabditis sinica | From_analysis | WormBase-Compara |
| | | FL83_14281 | Caenorhabditis latens | From_analysis | WormBase-Compara |
| | | GCK72_001016 | Caenorhabditis remanei | From_analysis | WormBase-Compara |
| | | OTIPU.nOt.2.0.1.g04668 | Oscheius tipulae | From_analysis | WormBase-Compara |
| | | Pan_g14184 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Pan_g17746 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Pan_g4707 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Sp34_10293700 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | chrI_pilon.g1026 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00248014 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00111246 | Pristionchus pacificus | From_analysis | WormBase-Compara |
| | | WBGene00259111 | Strongyloides ratti | From_analysis | WormBase-Compara |
| | | SGD:S000006130 | Saccharomyces cerevisiae | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | FB:FBgn0024227 | Drosophila melanogaster | From_analysis | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoFinder |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | PhylomeDB |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-040801-161 | Danio rerio | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | ZFIN:ZDB-GENE-020419-40 | Danio rerio | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | HGNC:11393 | Homo sapiens | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | HGNC:11391 | Homo sapiens | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | HGNC:11390 | Homo sapiens | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | MGI:1321119 | Mus musculus | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | MGI:107168 | Mus musculus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | MGI:894678 | Mus musculus | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | RGD:621625 | Rattus norvegicus | From_analysis | EnsEMBL-Compara |
| | | | | | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | RGD:628895 | Rattus norvegicus | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | | RGD:1309573 | Rattus norvegicus | From_analysis | Hieranoid |
| | | | | | Inparanoid |
| | | | | | OMA |
| | | | | | OrthoInspector |
| | | | | | Panther |
| | | | | | SonicParanoid |
| | Paralog | WBGene00000098 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | air-2 encodes an aurora/Ipl1-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 i modified in vitro by the GEI-17 E3 SUMO ligase; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies. | Paper_evidence (12) |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | | WBPerson363 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 10 Jun 2015 00:00:00 |
| | | Automated_description | Enables ATPase binding activity; kinesin binding activity; and protein kinase activity. Involved in several processes, including chromosome condensation; regulation of actomyosin contractile ring contraction; and spindle midzone assembly. Located in condensed nuclear chromosome and spindle midzone. Expressed in oocyte and sperm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human AURKB (aurora kinase B). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) |
| | | DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) |
| | | DOID:3008 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) |
| | | DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11390,HGNC:11393) |
| | | DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) |
| | | DOID:0070183 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11391) |
| | | DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) |
| | | DOID:8634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11390,HGNC:11393) |
| | | DOID:2152 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) |
| | | DOID:363 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) |
| Molecular_info | Corresponding_CDS | B0207.4 |
| | Corresponding_transcript | B0207.4.1 |
| | | B0207.4.2 |
| | Other_sequence (54) |
| | Associated_feature | WBsf217728 |
| | | WBsf217729 |
| Experimental_info | RNAi_result (63) |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00037734 |
| | Construct_product | WBCnstr00000897 |
| | | WBCnstr00005318 |
| | | WBCnstr00005560 |
| | | WBCnstr00014917 |
| | | WBCnstr00017655 |
| | | WBCnstr00021506 |
| | | WBCnstr00037734 |
| | Antibody | WBAntibody00000198 |
| | | WBAntibody00000511 |
| | | WBAntibody00001492 |
| | | WBAntibody00002053 |
| | | WBAntibody00002354 |
| | | WBAntibody00002454 |
| | | WBAntibody00002607 |
| | | WBAntibody00002722 |
| | | WBAntibody00002782 |
| | Microarray_results (21) |
| | Expression_cluster (167) |
| | Interaction (256) |
| Map_info | Map | I | Position | 0.482005 | Error | 0.002155 |
| | Well_ordered |
| | Positive | Positive_clone | B0207 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | C32E7 |
| | Negative | Outside_rearr | hDf29 |
| | | Negative_clone | C03E6 |
| | | | C04F1 |
| | | | C07F10 |
| | | | C30B6 |
| | | | C53A11 |
| | Mapping_data | 2_point | 5225 |
| | | | 5226 |
| | | Multi_point | 3520 |
| | | | 3865 |
| | | | 4380 |
| | | | 4601 |
| | | Pos_neg_data (12) |
| Reference (120) |
| Remark | [McDowall JS] Extrachromosomal array containing single cosmid generated, then manipulated genetically. Partial rescue: normally sterile adult with tumorous mass, develops to tumorless egg-laying adult, eggs do not develop or hatch. |
| | testing swap around with sup-40, from 0.435 to 0.575 |
| | same as cyk-6 according to cgc4544 and email 114. |
| | same as air-2 according to cgc4544 and email 114. |
| | old_name cyk-6 becomes new_name air-2 from [Woollard A, Hodgkin JA, Schumacher J]. |
| | old_names let-603 and stu-7 had previously been identitifed with air-2. |
| Method | Gene |
