WormBase Tree Display for Gene: WBGene00000084
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| WBGene00000084 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | aex-1 | Person_evidence | WBPerson655 | |||||
| Sequence_name | D2030.10 | ||||||||
| Molecular_name | D2030.10a | ||||||||
| D2030.10a.1 | |||||||||
| CE30740 | |||||||||
| D2030.10b | |||||||||
| CE30741 | |||||||||
| D2030.10b.1 | |||||||||
| Other_name | CELE_D2030.10 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | aex-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aex | ||||||||
| Allele (75) | |||||||||
| Legacy_information | [Jim Thomas] sa9: defecation defective, severely constipated, anterior body contraction (aBoc) and expulsion muscle contraction (Exp) steps of defecation nearly always missing, adult males not constipated and mate well. | ||||||||
| See also sa9, sa10, sa27, sa49 | |||||||||
| [C.elegansII] sa9: defecation defective, severely constipated, anterior body contraction (aBoc) and expulsion muscle contraction (Exp) steps of defecation nearly always missing, adult males not constipated and mate well. OA3: sa10, sa27 (weaker), sa49 (weaker)[Thomas 1990: JT] | |||||||||
| Strain | WBStrain00022772 | ||||||||
| WBStrain00024087 | |||||||||
| WBStrain00024088 | |||||||||
| WBStrain00024089 | |||||||||
| WBStrain00024090 | |||||||||
| WBStrain00024086 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (24) | |||||||||
| Paralog | WBGene00018837 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | aex-1 encodes a novel, C2 calcium-binding domain protein that is similar to human BAP3 proteins and rat Munc13; in C. elegans, AEX-1 functions in retrograde signaling to regulate presynaptic activity and localization of the synaptic vesicle fusion protein UNC-13; AEX-1 is required for the defecation motor program, specifically the anterior body wall and enteric muscle contractions, and for normal locomotion, male mating, and egg laying; mutation of dgk-1, or a gain-of-function mutation of egl-30, suppresses the aex-1 mutant phenotype; AEX-1 is expressed primarily in the anterior and posterior intestine and in body wall muscle cells; tissue-specific expression in the intestine rescues defecation defects, while expression in body wall muscle cells rescues UNC-13 localization defects; genetic analyses suggest that aex-1 and aex-5, which encodes a prohormone convertase, function in the same pathway to regulate retrograde signaling at neuromuscular junctions. | Paper_evidence | WBPaper00001256 | |||||
| WBPaper00005092 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Jul 2011 00:00:00 | ||||||||
| Automated_description | Involved in several processes, including lipid transport involved in lipid storage; positive regulation of transport; and reproductive behavior. Predicted to be located in exocytic vesicle. Expressed in amphid neurons; body wall musculature; and intestine. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | D2030.10a | |||||||
| D2030.10b | |||||||||
| Corresponding_CDS_history | D2030.10:wp79 | ||||||||
| Corresponding_transcript | D2030.10a.1 | ||||||||
| D2030.10b.1 | |||||||||
| Other_sequence | AF324832 | ||||||||
| EY472436.1 | |||||||||
| ACC06893_1 | |||||||||
| Associated_feature | WBsf643475 | ||||||||
| WBsf656548 | |||||||||
| WBsf981049 | |||||||||
| WBsf984234 | |||||||||
| WBsf984235 | |||||||||
| WBsf218052 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1805 | ||||||||
| Expr1017083 | |||||||||
| Expr1147462 | |||||||||
| Expr2009246 | |||||||||
| Expr2027483 | |||||||||
| Drives_construct | WBCnstr00010462 | ||||||||
| WBCnstr00037744 | |||||||||
| Construct_product | WBCnstr00010462 | ||||||||
| WBCnstr00037744 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (126) | |||||||||
| SAGE_tag | SAGE:ttacttggat | Strand | Sense | ||||||
| Unambiguously_mapped | |||||||||
| SAGE:gagagaagtt | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:tggagcattcccaaaac | Strand | Antisense | |||||||
| SAGE:ccgacaattggaattga | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:ttacttggataatttga | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:ttgatgtacatatttca | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| Interaction (26) | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | I | Position | 2.2079 | Error | 0.002725 | |||
| Positive | Positive_clone | D2030 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 4228 | |||||||
| Multi_point | 1480 | ||||||||
| 1481 | |||||||||
| 1693 | |||||||||
| 1694 | |||||||||
| 5298 | |||||||||
| Pos_neg_data | 4750 | ||||||||
| 4751 | |||||||||
| 4764 | |||||||||
| 4765 | |||||||||
| 5959 | |||||||||
| 5960 | |||||||||
| Reference (15) | |||||||||
| Method | Gene |
