WormBase Tree Display for Gene: HGNC:3073
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| HGNC:3073 | Identity | Name | CGC_name | Dusp7 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name | RGD:1350752 | |||||
| DKFZp586F2224 | ||||||
| MKPX | ||||||
| PYST2 | ||||||
| dual specificity protein phosphatase 7 | ||||||
| dual specificity protein phosphatase PYST2 | ||||||
| dual-specificity phosphatase-7 | ||||||
| Public_name | Dusp7 | |||||
| DB_info | Database | HGNC | id | 3073 | ||
| AGR | cURI | HGNC:3073 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000164086 | ||||
| UniProt | UniProt_AC | Q16829 | ||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00003043 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | ||
| Hieranoid | ||||||
| Inparanoid | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| Structured_description | Automated_description | Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] | Inferred_automatically | AGR_import |
