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WormBase Tree Display for Gene: WBGene00003043

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Name Class

WBGene00003043SMapS_parentSequenceC05B10
IdentityVersion1
NameCGC_namelip-1Person_evidenceWBPerson232
Sequence_nameC05B10.1
Molecular_nameC05B10.1a
C05B10.1a.1
CE31151
C05B10.1b
CE49310
C05B10.1b.1
C05B10.1c
Other_nameCELE_C05B10.1Accession_evidenceNDBBX284604
Public_namelip-1
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlip
Allele (45)
StrainWBStrain00000142
WBStrain00001321
WBStrain00000141
WBStrain00000146
WBStrain00022639
WBStrain00051597
RNASeq_FPKM (74)
GO_annotation (62)
Ortholog (42)
ParalogWBGene00006923Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00007302Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00007697Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00009142Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00009207Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00014074Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00015807Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00017428Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021867Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionlip-1 encodes a mitogen-activated protein (MAP) kinase phosphatase homologous to the vertebrate dual specificity phosphatase MKP-3; during development, LIP-1 negatively regulates MAP kinase activity to control the extent of germline proliferation and oocyte meiotic cell cycle progression; lip-1 activity is also required redundantly with dep-1 to negatively regulate MAPK signaling during vulval induction; in addition, lip-1 is required for normal embryonic development; lip-1 expression begins during embryogenesis and continues through adulthood; expression is seen in most somatic cells and in germ cells of the pachytene region, transition zone and proximal-most region of the mitotic zone; in the pachytene region, LIP-1 is associated with the plasma membrane; in early L3 larvae, LIP-1 expression increases in secondary vulval precursor cells in a lin-12/Notch-dependent manner, suggesting that lip-1 may be a direct downstream target of lin-12-mediated signaling; interaction with the Notch pathway is further demonstrated by chromatin immunoprecipitation experiments showing that, in the germline, the lip-1 promoter region coprecipitates with LAG-3; germline lip-1 mRNA accumulation is negatively regulated by the FBF proteins (FBF-1 and FBF-2) that bind to the lip-1 3'UTR.Paper_evidenceWBPaper00004542
WBPaper00005425
WBPaper00025197
WBPaper00026961
Curator_confirmedWBPerson1843
Date_last_updated27 Nov 2006 00:00:00
Automated_descriptionPredicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Involved in several processes, including negative regulation of Ras protein signal transduction; positive regulation of vulval development; and vulval cell fate specification. Located in plasma membrane. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and germ line. Human ortholog(s) of this gene implicated in breast cancer and hypogonadotropic hypogonadism 19 with or without anosmia. Is an ortholog of human DUSP6 (dual specificity phosphatase 6) and DUSP7 (dual specificity phosphatase 7).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Disease_infoPotential_modelDOID:0090090Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3072)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3072)
Molecular_infoCorresponding_CDSC05B10.1a
C05B10.1b
Corresponding_transcriptC05B10.1c
C05B10.1a.1
C05B10.1b.1
Other_sequence (19)
Associated_featureWBsf660248
WBsf718114
WBsf996841
WBsf996842
WBsf996843
WBsf1017628
Experimental_infoRNAi_resultWBRNAi00010167Inferred_automaticallyRNAi_primary
WBRNAi00087951Inferred_automaticallyRNAi_primary
WBRNAi00075905Inferred_automaticallyRNAi_primary
WBRNAi00007925Inferred_automaticallyRNAi_primary
WBRNAi00087228Inferred_automaticallyRNAi_primary
WBRNAi00039684Inferred_automaticallyRNAi_primary
Expr_pattern (14)
Drives_constructWBCnstr00000956
WBCnstr00000958
WBCnstr00002214
WBCnstr00005189
WBCnstr00005285
WBCnstr00005411
WBCnstr00008051
WBCnstr00008476
Construct_productWBCnstr00005241
WBCnstr00006272
AntibodyWBAntibody00000542
WBAntibody00000958
WBAntibody00001202
Microarray_results (20)
Expression_cluster (162)
Interaction (78)
Anatomy_functionWBbtf0120
Map_infoMapIVPosition3.24356Error0.000851
PositivePositive_cloneC05B10Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4478
4737
5424
Pseudo_map_position
Reference (69)
Remarkemail 41 from wen chen.
Sequence connection from [Berset T, Hajnal AF]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene