WormBase Tree Display for Expr_pattern: Expr9049
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| Expr9049 | Expression_of | Gene | WBGene00017270 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00017270 | |||
| Expression_data | Anatomy_term | WBbt:0003681 | Certain | |
| WBbt:0005772 | Certain | |||
| WBbt:0005821 | Certain | |||
| WBbt:0006751 | Certain | |||
| GO_term | GO:0005634 | |||
| Subcellular_localization | NUMR-1 was concentrated in the nuclei of the expressing cells. Nuclear-accumulated NUMR-1GFP was clearly observed as punctate structures within the intestinal nuclei of cadmium-treated nematodes. NUMR-1 colocalized with HSF-1 after cadmium treatment. This result suggests that NUMR-1 may be a component of nuclear stress granules. | |||
| Type | Reporter_gene | |||
| Pattern | In the absence of metal, the cellular pattern of NUMR-1 expression was identical to that observed in JF85(mtEx60) nematodes . NUMR-1 was constitutively expressed in intestinal cells of L1 nematodes and the level of expression decreased as the nematodes developed. NUMR-1 was also expressed in neurons in the head, egg-laying muscles of the vulva, and a few cells in the tail. When exposed to cadmium, NUMR-1 expression increased in intestinal and pharyngeal nuclei. This pattern was similar to that observed for JF85(mtEx60) C. elegans. Following copper exposure, NUMR-1 expression in adult nematodes increased only in pharyngeal nuclei. Similar patterns of expression were observed in larval C. elegans in the presence and absence of the metals. | |||
| Picture | WBPicture0000009112 | |||
| Remark | Picture: Fig 4, Fig 5. | |||
| Reference | WBPaper00036303 | |||
| Transgene | WBTransgene00008687 |
