WormBase Tree Display for WBProcess: WBbiopr:00000077
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| WBbiopr:00000077 | Public_name | Unfolded protein response - Mitochondrial | ||||
|---|---|---|---|---|---|---|
| Summary | Similar to the unfolded protein response in the endoplasmic reticulum, the mitochondrial UPR functions to maintain a homeostasis of the protein folding pathways. The UPR(mt) employs a mitochondria-to-nuclear signal transduction pathway, which regulates the expression of mitochondrial protective genes such as mitochondria-specific molecular chaperones and proteases. An increase in Cytochrome c Oxidase (COX) and succinate dehydrogenase (SDH) activity is an indicator of mitochondrial stress. | |||||
| Other_name | UPR(mt) | |||||
| Mitochondrial response to proteotoxic stress | ||||||
| Related_topic | Specialisation_of | WBbiopr:00000079 | ||||
| Involved_entity | Gene (11) | |||||
| Interaction (1014) | ||||||
| Molecule | WBMol:00003893 | Paper_evidence | WBPaper00038075 | |||
| WBMol:00005361 | Paper_evidence | WBPaper00024269 | ||||
| WBPaper00031084 | ||||||
| Associated_with | GO_term | GO:0034514 | ||||
| GO:0005739 | ||||||
| Pathway | DB_info | Database | WikiPathways | Pathway | WP525 | |
| Remark | "WikiPathways" "Pathway" "WP525" | |||||
| Reference (92) |
