WormBase Tree Display for Variation: WBVar02143822
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| WBVar02143822 | Evidence | Paper_evidence | WBPaper00046065 | ||||
|---|---|---|---|---|---|---|---|
| Name | Public_name | lt1 | |||||
| Sequence_details | Mapping_target | F35B3 | |||||
| Type_of_mutation | Deletion | ||||||
| SeqStatus | Pending_curation | ||||||
| Variation_type | Allele | ||||||
| Transposon_insertion | |||||||
| Origin | Species | Caenorhabditis elegans | |||||
| Laboratory | OD | ||||||
| Status | Live | ||||||
| Affects | Gene | WBGene00004121 | |||||
| Interactor | WBInteraction000524593 | ||||||
| WBInteraction000524594 | |||||||
| Isolation | Transposon_excision | Mos1 | |||||
| Description | Phenotype | WBPhenotype:0000036 | Paper_evidence | WBPaper00048540 | |||
| Curator_confirmed | WBPerson12586 | ||||||
| Remark | At 72-hour after bleach synchronization and release, worms that are homozygous for both lt1 and ok3692 have a body length that is only ~50% of wild type or single mutant controls. | Paper_evidence | WBPaper00048540 | ||||
| Curator_confirmed | WBPerson12586 | ||||||
| Surviving worms homozygous for lt1, lt19 and ltSi794 are about half the size of age-matching wild type. | Paper_evidence | WBPaper00048540 | |||||
| Curator_confirmed | WBPerson12586 | ||||||
| WBPhenotype:0000058 | Paper_evidence | WBPaper00048540 | |||||
| Curator_confirmed | WBPerson12586 | ||||||
| Remark | Worms that are homozygous for both lt1 and ok3692 rupture and die starting from L4 stage. ~15% of worms die at L4 stage after L1 release from bleach synchronization. | Paper_evidence | WBPaper00048540 | ||||
| Curator_confirmed | WBPerson12586 | ||||||
| WBPhenotype:0000060 | Paper_evidence | WBPaper00048540 | |||||
| Curator_confirmed | WBPerson12586 | ||||||
| Remark | About 60% of worms that are homozygous for both lt1 and ok3692 rupture and die at 72-hour after L1 release from bleach synchronization. This is the 1st day adult. | Paper_evidence | WBPaper00048540 | ||||
| Curator_confirmed | WBPerson12586 | ||||||
| 80% of worms homozygous for lt1, lt19 and ltSi794 rupture and die at 72-hour after bleach synchronization and release. | Paper_evidence | WBPaper00048540 | |||||
| Curator_confirmed | WBPerson12586 | ||||||
| WBPhenotype:0000685 | Paper_evidence | WBPaper00048540 | |||||
| Curator_confirmed | WBPerson12586 | ||||||
| Remark | Worms that are homozygous for both lt1 and ok3692 grow slower than wild type or single mutant controls. At the L4 stage, their body length are only about 2/3 of wild type or single mutant controls. | Paper_evidence | WBPaper00048540 | ||||
| Curator_confirmed | WBPerson12586 | ||||||
| lt19 is a GFP knock-in at the C-terminal of gip-2 locus, while ltSi794 transgene encodes a GFP nanobody::ZIF-1 fusion specifically in the epidermis. This fusion protein degrades GIP-2::GFP. Worms homozygous for lt1, lt19 and ltSi794 grow slower than controls during larval development. | Paper_evidence | WBPaper00048540 | |||||
| Curator_confirmed | WBPerson12586 | ||||||
| Reference | WBPaper00046065 | ||||||
| WBPaper00048540 | |||||||
| Remark | ptrn-1(lt1) was generated by MosDEL and deletes most of ptrn-1 | Paper_evidence | WBPaper00046065 | ||||
| Method | Transposon_insertion |
