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WormBase Tree Display for Variation: WBVar00095116

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Name Class

WBVar00095116EvidencePaper_evidenceWBPaper00002585
NamePublic_namep678
Other_nameCE27352:p.Gln82Ter
ZC84.2.1:c.244C>T
HGVSgCHROMOSOME_III:g.9181987C>T
Sequence_detailsSMapS_parentSequenceZC84
Flanking_sequencesaatgcagttcaaccagcggccaccggtggtagccggcatcttccgatggcggttcagcta
Mapping_targetZC84
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00002585
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00003905
WBStrain00003907
WBStrain00022726
WBStrain00022727
WBStrain00023534
WBStrain00023536
WBStrain00023537
WBStrain00030785
LaboratoryPR
StatusLive
AffectsGeneWBGene00006526
TranscriptZC84.2.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScZC84.2.1:c.244C>T
HGVSpCE27352:p.Gln82Ter
cDNA_position248
CDS_position244
Protein_position82
Exon_number4/12
Codon_changeCag/Tag
Amino_acid_changeQ/*
InteractorWBInteraction000500199
WBInteraction000501269
WBInteraction000501491
WBInteraction000501857
WBInteraction000501960
WBInteraction000501961
WBInteraction000503645
WBInteraction000520472
WBInteraction000535467
WBInteraction000535468
WBInteraction000535469
WBInteraction000535471
WBInteraction000535472
GeneticsInterpolated_map_positionIII0.283998
DescriptionPhenotypeWBPhenotype:0000039Paper_evidenceWBPaper00032237
Curator_confirmedWBPerson712
RemarkThe average lifespan was increased compared to control rrf-3(pk1426) animals.Paper_evidenceWBPaper00032237
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00032237
Curator_confirmedWBPerson712
Genotyperrf-3(pk1426)Paper_evidenceWBPaper00032237
Curator_confirmedWBPerson712
WBPhenotype:0000061Paper_evidenceWBPaper00045085
WBPaper00060588
Curator_confirmedWBPerson21384
WBPerson282
RemarkThe average lifespan was increased compared to wild-type animals.Paper_evidenceWBPaper00045085
Curator_confirmedWBPerson21384
WBPhenotype:0000134Paper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
RemarkMutations decreased overall levels of str-2 expressionPaper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005672PATO:0000460Paper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
WBPhenotype:0000154Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000254Paper_evidenceWBPaper00031959
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkAnimals were completely defective in NaCl chemotaxis but not to NaAc in water soluble assays compared to wild-type.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
repelled by Cl; athermotactic; reduced brood sizePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
WBMol:00001360Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_assayTreatmentFor the water soluble chemotaxis assay, radial gradients of NaCl were established by diffusion in the agar.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
WBPhenotype:0000295Paper_evidenceWBPaper00060588
Curator_confirmedWBPerson282
WBPhenotype:0000302Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
RemarkThe tax-4(p678) mutation resulted in defects in chemotaxis to benzaldehyde (Figure S1D)Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002087Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
WBPhenotype:0000414Paper_evidenceWBPaper00030973
Curator_confirmedWBPerson2021
RemarkEctopic expression of ASE fate in AFD via lim-6 reporter. No effect on gcy-7 and gcy-5 reportersPaper_evidenceWBPaper00030973
Curator_confirmedWBPerson2021
PenetranceHigh86 percentPaper_evidenceWBPaper00030973
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00030973
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005662PATO:0000460Paper_evidenceWBPaper00030973
Curator_confirmedWBPerson2021
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00030973
Curator_confirmedWBPerson2021
Phenotype_assayTemperature20CPaper_evidenceWBPaper00030973
Curator_confirmedWBPerson2021
GenotypeotIs6 [lim-6p::GFP], ntIs1[gcy-5p::GFP], otIs3 [ gcy-7p::GFP]Paper_evidenceWBPaper00030973
Curator_confirmedWBPerson2021
WBPhenotype:0000478Paper_evidenceWBPaper00042411
Curator_confirmedWBPerson2987
RemarkFigure 9Paper_evidenceWBPaper00042411
Curator_confirmedWBPerson2987
EQ_annotationsGO_termGO:0043052PATO:0000460Paper_evidenceWBPaper00042411
Curator_confirmedWBPerson2987
WBPhenotype:0000481Paper_evidenceWBPaper00065019
Curator_confirmedWBPerson712
RemarkArgentine ant extracts also repelled tax-4 mutants (tax-4: solvent vs Argentine ant extract, t(40) = 4.615, p = 0.002),Paper_evidenceWBPaper00065019
Curator_confirmedWBPerson712
Extracts of the Velvety tree ant showed a different pattern of behavioral response, in which tax-4 mutants were repelled by the extracts (tax-4: solvent vs Velvety tree ant extract, t(40) = 5.645, p < 0.001), but osm-9 mutants (osm-9: solvent vs Velvety tree ant extract, t(40) = 0.018, p = 0.985) and the wild type (PD1074: solvent vs Velvety tree ant extract, t(40) = 1.096, p = 0.373) were not.Paper_evidenceWBPaper00065019
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00008002Paper_evidenceWBPaper00065019
Curator_confirmedWBPerson712
WBMol:00008001Paper_evidenceWBPaper00065019
Curator_confirmedWBPerson712
WBPhenotype:0000637Paper_evidenceWBPaper00060588
Curator_confirmedWBPerson282
WBPhenotype:0000999Paper_evidenceWBPaper00035614
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
RemarkThe tax-4 mutant presents an athermotactic response under all conditions testedPaper_evidenceWBPaper00035614
Curator_confirmedWBPerson2021
athermotactic; reduced brood sizePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001042Paper_evidenceWBPaper00031992
Curator_confirmedWBPerson712
RemarkAll responses to NaCl upsteps and down-steps in ASEL and ASER were eliminated as imaged by calcium responses.Paper_evidenceWBPaper00031992
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005663PATO:0000460Paper_evidenceWBPaper00031992
Curator_confirmedWBPerson712
Phenotype_assayTemperatureCalcium transients in ASE neurons were measured in response to NaCl concentration steps of 40mM from a baseline of 40 mM.Paper_evidenceWBPaper00031992
Curator_confirmedWBPerson712
WBPhenotype:0001084Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
RemarkAnimals were completely defective in NaCl chemotaxis in water soluble assays.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Phenotype_assayTreatmentFor the water soluble chemotaxis assay, radial gradients of NaCl were established by diffusion in the agar.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
WBPhenotype:0001234Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
RemarkThe tax-4(p678) mutation resulted in defects in chemotaxis to nonanone (Figure S1D)Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00001711Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
WBPhenotype:0001273Paper_evidenceWBPaper00031874
Curator_confirmedWBPerson2021
RemarkMutations affecting the AFD or AIY neurons reduced heat shock-dependent accumulation of hsp70 (C12C8.1) mRNA at 30C and 34CPaper_evidenceWBPaper00031874
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00031874
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentAnimals were exposed to a transient increase in temperature (30C or 34C for 15 min), and their heat shock response was measured as the total amount of hsp70 (C12C8.1) mRNA, 2 hours after heat shockPaper_evidenceWBPaper00031874
Curator_confirmedWBPerson2021
WBPhenotype:0001410Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
RemarkNo staining of activated MAP kinase was observed, even in after odorant stimulus, whereas immunoreactivity against the anti-activated-MAPK antibody was observed in the AWC neurons (and others) after 10 seconds of application with isoamylalcohol.Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001063Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBPhenotype:0001434Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkdefective chemotaxis to Na, cAMP; repelled by Cl; athermotactic; reduced brood sizePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004782Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBMol:00002962Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001435Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
RemarkAnimals showed a reduction in chemotaxis to ammonium chloride compared to wild-type and were significantly defective in comparison to positive control che-1(p679) animals.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002092Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Phenotype_assayTreatmentFor the soluble assay, radial gradients of NH4Cl were established by diffusion in the agar.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
WBPhenotype:0001438Paper_evidenceWBPaper00001786
Curator_confirmedWBPerson2021
RemarkDefective in chemotaxis to volatile odorants including benzaldehyde, 2-butanone and isoamyl alcohol (Data not shown).Paper_evidenceWBPaper00001786
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00001786
Curator_confirmedWBPerson2021
WBPhenotype:0001442Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
RemarkAnimals showed a reduction in chemotaxis to sodium acetate compared to wild-type animals but, animals still showed residual positive chemotaxis similar to che-1(p679).Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004924Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Phenotype_assayTreatmentFor the soluble assay, radial gradients of NaAc were established by diffusion in the agar.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
WBPhenotype:0001469Paper_evidenceWBPaper00032215
Curator_confirmedWBPerson712
RemarkAnimals exhibited weak, if any, attraction to butanone.Paper_evidenceWBPaper00032215
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00005086Paper_evidenceWBPaper00032215
Curator_confirmedWBPerson712
WBPhenotype:0001484Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
RemarkThe tax-4(p678) mutation resulted in defects in chemotaxis to ammonium acetate (Figure S1D)Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002790Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
WBPhenotype:0001661Paper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
RemarkMutations sometimes resulted in 2 AWC OFF cells. Mutants occasionally expressed str-2 in both AWC neurons, but one neuron was usually much fainter than the otherPaper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005672PATO:0000460Paper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
WBPhenotype:0001692Paper_evidenceWBPaper00028386
Curator_confirmedWBPerson712
RemarkILD defective and suppressed CLD of srf-6; as assayed by the lack of staining by mAb M37 of L2 animals grown on plates containing crude pheromone.Paper_evidenceWBPaper00028386
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were grown synchronously from hatching to L2 on NGM plates containing crude pheromone extract.Paper_evidenceWBPaper00028386
Curator_confirmedWBPerson712
WBPhenotype:0001738Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
RemarkAnimals were defective in ammonium chemotaxis in water soluble assays when compared to che-1(p679) positive control animals.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002091Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Phenotype_assayTreatmentFor the water soluble chemotaxis assay, radial gradients of NH4Cl were established by diffusion in the agar.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
WBPhenotype:0001764Paper_evidenceWBPaper00037908
Curator_confirmedWBPerson557
RemarkThe carbon dioxide-evoked calcium transients of BAG neurons were eliminated.Paper_evidenceWBPaper00037908
Curator_confirmedWBPerson557
WBPhenotype:0001765Paper_evidenceWBPaper00031935
WBPaper00031936
WBPaper00045598
Curator_confirmedWBPerson712
WBPerson2021
RemarkCarbon dioxide avoidance (Cdad) was completely disrupted in the presence of food, but not in the absence of food.Paper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
Acute CO2 avoidance is eliminatedPaper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Null mutants do not avoid high CO2.Paper_evidenceWBPaper00045598
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003023Paper_evidenceWBPaper00045598
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentStrains were maintained at 22C. Animals were exposed to a 5% to 0% CO2 gradient.Paper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
10% CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
WBPhenotype:0001790Paper_evidenceWBPaper00032060
Curator_confirmedWBPerson712
RemarkNo change in AFD membrane potential was observed when animals were treated with temperature ramps.Paper_evidenceWBPaper00032060
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005662PATO:0000460Paper_evidenceWBPaper00032060
Curator_confirmedWBPerson712
WBPhenotype:0002014Paper_evidenceWBPaper00036207
Curator_confirmedWBPerson712
RemarkGTP-gamma S stimulated inward current in ASJ was absent in the CNG channel mutants. Mastoparan elicited inward currents were blocked.Paper_evidenceWBPaper00036207
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001587Paper_evidenceWBPaper00036207
Curator_confirmedWBPerson712
WBMol:00004020Paper_evidenceWBPaper00036207
Curator_confirmedWBPerson712
WBPhenotype:0002171Paper_evidenceWBPaper00042397
Curator_confirmedWBPerson1928
RemarkAnimals are defective in chemotaxis towards attractive alkaline pHPaper_evidenceWBPaper00042397
Curator_confirmedWBPerson1928
WBPhenotype:0002199Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
RemarkThe tax-4(p678) mutant, unlike wild type, exhibited no GCaMP3 signal (indicative of calcium concentration changes) in AFD neurons (in vivo or isolated in culture) in response to increasing temperature; "In addition, mutations in the molecular components essential for AFD thermosensation, GCY-8, GCY-18, and GCY-23 guanylyl cyclases, or the TAX-4 cGMP-gated cation channel (Inada et al., 2006; Komatsu et al., 1996), abolished thermal response of AFD in both cultured and in vivo conditions (Figure S1B; Table S1)."Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005662PATO:0000460Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
Phenotype_assayGenotypenjIs24[gcy-8p::GCaMP3, gcy-8p::TagRFP] (I); Parent strain: IK1154Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
WBPhenotype:0002638Paper_evidenceWBPaper00060871
Curator_confirmedWBPerson53483
RemarkCompromised response to oomycetes, specifically Myzocytiopsis humicolaPaper_evidenceWBPaper00060871
Curator_confirmedWBPerson53483
Phenotype_not_observedWBPhenotype:0000012Paper_evidenceWBPaper00038115
Curator_confirmedWBPerson712
RemarkLess than 5% dauer at either 15 or 25 deg C.Paper_evidenceWBPaper00038115
Curator_confirmedWBPerson712
WBPhenotype:0001285Paper_evidenceWBPaper00045598
Curator_confirmedWBPerson712
RemarkMutants show a significant reduction in pumping following exposure to 10% CO2, similar to the reduction observed in wild-type (N2) animalsPaper_evidenceWBPaper00045598
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003023Paper_evidenceWBPaper00045598
Curator_confirmedWBPerson712
WBPhenotype:0001474Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
RemarkThe tax-4(p678) mutation did not affect animals' chemotaxis response to pyrazine (Figure S1D)Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00005360Paper_evidenceWBPaper00041842
Curator_confirmedWBPerson2987
WBPhenotype:0001616Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
RemarkTrimethadione significantly extended life-span of mutant animals (N=52)(1 ind.exp.), as observed for WT animals.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Phenotype_assayTreatmentLifespan analysis was performed on animals exposed to 4 mg/ml of the drug from fertilization until death. Animals were cultured on NGM plates containing the drug and seeded with OP50.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Temperature20CPaper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
WBPhenotype:0001660Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
RemarkNo disruption of ASE asymmetry (as seen with lim-6 reporters)Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
Phenotype_assayGenotypeotIs114, otIs6Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
WBPhenotype:0001690Paper_evidenceWBPaper00028386
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were grown synchronously from hatching to L2 on NGM plates containing crude pheromone extract.Paper_evidenceWBPaper00028386
Curator_confirmedWBPerson712
WBPhenotype:0001736Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
RemarkAnimals showed no defect in acetate chemotaxis in water soluble assays when compared to che-1(p679) positive control animals.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00005057Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
Phenotype_assayTreatmentFor the water soluble chemotaxis assay, radial gradients of NaAc were established by diffusion in the agar.Paper_evidenceWBPaper00031959
Curator_confirmedWBPerson712
WBPhenotype:0001897Paper_evidenceWBPaper00032087
Curator_confirmedWBPerson2021
RemarkLoss-of-function mutations in the TAX-4 CNG channels do not affect the overall locomotion response to short wavelength lightPaper_evidenceWBPaper00032087
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00032087
Curator_confirmedWBPerson2021
ReferenceWBPaper00038115
WBPaper00041842
WBPaper00032237
WBPaper00024698
WBPaper00011986
WBPaper00031936
WBPaper00031935
WBPaper00006052
WBPaper00031874
WBPaper00030973
WBPaper00001786
WBPaper00019249
WBPaper00031959
WBPaper00028386
WBPaper00014724
WBPaper00032087
WBPaper00014951
WBPaper00036207
WBPaper00032215
WBPaper00003760
WBPaper00003955
WBPaper00031992
WBPaper00032060
WBPaper00011929
WBPaper00035614
WBPaper00024095
WBPaper00019210
WBPaper00042411
WBPaper00042397
WBPaper00045085
WBPaper00045598
WBPaper00049050
WBPaper00060871
WBPaper00064927
WBPaper00037908
WBPaper00060588
WBPaper00065019
RemarkCorrected from pr678 appeared In 2002 European Worm Meeting abstractPerson_evidenceWBPerson712
MethodSubstitution_allele