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WormBase Tree Display for Variation: WBVar00092599

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Name Class

WBVar00092599EvidencePaper_evidenceWBPaper00040209
NamePublic_nameok1384
Sequence_detailsPCR_productOK1384_external
OK1384_internal
SeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004711
WBStrain00031984
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00003096
GeneticsMapping_dataIn_multi_point4881
DescriptionPhenotypeWBPhenotype:0001012Paper_evidenceWBPaper00055320
Curator_confirmedWBPerson557
RemarkThis mutant showed no protection from enterotoxigenic Escherichia coli (ETEC) infection when pretreated with Lactobacillus zeae LB1. Authors show that wild type worms had "enhancement in the resistance" to infection by ETEC when worms were first grown on Lactobacillus zeae LB1. This "enhancement in resistance" is not observed in this mutant.Paper_evidenceWBPaper00055320
Curator_confirmedWBPerson557
Phenotype_assayTreatmentAnimals were grown on plates containing K88plus enterotoxigenic Escherichia coli(ETEC) strain JG280 after pretreatment with Lactobacillus zeae LB1.Paper_evidenceWBPaper00055320
Curator_confirmedWBPerson557
WBPhenotype:0001013Paper_evidenceWBPaper00040209
WBPaper00055320
Curator_confirmedWBPerson712
WBPerson557
RemarkKnock-out mutations resulted in significantly reduced resistance measures during exposure to pathogenic Bt (Bacillus thuringiensis); animals did not survive as long as WT on these lawns, whereas animals grown on DSM-350 exhibited survival curves similar to N2.Paper_evidenceWBPaper00040209
Curator_confirmedWBPerson712
This mutant is more susceptible to enterotoxigenic Escherichia coli infection compared with N2 wild-type animals.Paper_evidenceWBPaper00055320
Curator_confirmedWBPerson557
Phenotype_assayTreatmentAnimals grown on plates containing K88plus enterotoxigenic Escherichia coli (ETEC) strain JG280.Paper_evidenceWBPaper00055320
Curator_confirmedWBPerson557
Phenotype_not_observedWBPhenotype:0000231Paper_evidenceWBPaper00040209
Curator_confirmedWBPerson712
RemarkOn pathogenic Bt, the mutants did not significantly differ from the wild-type.Paper_evidenceWBPaper00040209
Curator_confirmedWBPerson712
WBPhenotype:0000659Paper_evidenceWBPaper00040209
Curator_confirmedWBPerson712
RemarkOn pathogenic Bt, the mutants did not significantly differ from the wild-type.Paper_evidenceWBPaper00040209
Curator_confirmedWBPerson712
WBPhenotype:0000673Paper_evidenceWBPaper00040209
Curator_confirmedWBPerson712
RemarkOn pathogenic Bt, the mutants did not significantly differ from the wild-type.Paper_evidenceWBPaper00040209
Curator_confirmedWBPerson712
WBPhenotype:0001819Paper_evidenceWBPaper00040209
Curator_confirmedWBPerson712
RemarkMutants did not suffer from a significantly higher infection load than N2.Paper_evidenceWBPaper00040209
Curator_confirmedWBPerson712
ReferenceWBPaper00040209
WBPaper00055320
MethodKO_consortium_allele