WormBase Tree Display for Variation: WBVar00092599
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WBVar00092599 | Evidence | Paper_evidence | WBPaper00040209 | |||||
---|---|---|---|---|---|---|---|---|
Name | Public_name | ok1384 | ||||||
Sequence_details | PCR_product | OK1384_external | ||||||
OK1384_internal | ||||||||
SeqStatus | Pending_curation | |||||||
Variation_type | Allele | |||||||
Origin | Species | Caenorhabditis elegans | ||||||
Strain | WBStrain00004711 | |||||||
WBStrain00031984 | ||||||||
Laboratory | RB | |||||||
Person | WBPerson46 | |||||||
KO_consortium_allele | ||||||||
Status | Live | |||||||
Affects | Gene | WBGene00003096 | ||||||
Genetics | Mapping_data | In_multi_point | 4881 | |||||
Description | Phenotype | WBPhenotype:0001012 | Paper_evidence | WBPaper00055320 | ||||
Curator_confirmed | WBPerson557 | |||||||
Remark | This mutant showed no protection from enterotoxigenic Escherichia coli (ETEC) infection when pretreated with Lactobacillus zeae LB1. Authors show that wild type worms had "enhancement in the resistance" to infection by ETEC when worms were first grown on Lactobacillus zeae LB1. This "enhancement in resistance" is not observed in this mutant. | Paper_evidence | WBPaper00055320 | |||||
Curator_confirmed | WBPerson557 | |||||||
Phenotype_assay | Treatment | Animals were grown on plates containing K88plus enterotoxigenic Escherichia coli(ETEC) strain JG280 after pretreatment with Lactobacillus zeae LB1. | Paper_evidence | WBPaper00055320 | ||||
Curator_confirmed | WBPerson557 | |||||||
WBPhenotype:0001013 | Paper_evidence | WBPaper00040209 | ||||||
WBPaper00055320 | ||||||||
Curator_confirmed | WBPerson712 | |||||||
WBPerson557 | ||||||||
Remark | Knock-out mutations resulted in significantly reduced resistance measures during exposure to pathogenic Bt (Bacillus thuringiensis); animals did not survive as long as WT on these lawns, whereas animals grown on DSM-350 exhibited survival curves similar to N2. | Paper_evidence | WBPaper00040209 | |||||
Curator_confirmed | WBPerson712 | |||||||
This mutant is more susceptible to enterotoxigenic Escherichia coli infection compared with N2 wild-type animals. | Paper_evidence | WBPaper00055320 | ||||||
Curator_confirmed | WBPerson557 | |||||||
Phenotype_assay | Treatment | Animals grown on plates containing K88plus enterotoxigenic Escherichia coli (ETEC) strain JG280. | Paper_evidence | WBPaper00055320 | ||||
Curator_confirmed | WBPerson557 | |||||||
Phenotype_not_observed | WBPhenotype:0000231 | Paper_evidence | WBPaper00040209 | |||||
Curator_confirmed | WBPerson712 | |||||||
Remark | On pathogenic Bt, the mutants did not significantly differ from the wild-type. | Paper_evidence | WBPaper00040209 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000659 | Paper_evidence | WBPaper00040209 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | On pathogenic Bt, the mutants did not significantly differ from the wild-type. | Paper_evidence | WBPaper00040209 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000673 | Paper_evidence | WBPaper00040209 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | On pathogenic Bt, the mutants did not significantly differ from the wild-type. | Paper_evidence | WBPaper00040209 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001819 | Paper_evidence | WBPaper00040209 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Mutants did not suffer from a significantly higher infection load than N2. | Paper_evidence | WBPaper00040209 | |||||
Curator_confirmed | WBPerson712 | |||||||
Reference | WBPaper00040209 | |||||||
WBPaper00055320 | ||||||||
Method | KO_consortium_allele |