WormBase Tree Display for Variation: WBVar00088953

WBVar00088953 Evidence: Paper_evidence: WBPaper00035199
  Name: Public_name: mg375
    Other_name: mg374Eri Paper_evidence: WBPaper00035199
      CE47418:p.Gly492Arg
      K12H4.8.1:c.1474G>A
    HGVSg: CHROMOSOME_III:g.8077980C>T
  Sequence_details: SMap: S_parent: Sequence: K12H4
    Flanking_sequences: acttgacatgagatcatacgttcagtcaaag gaagagctcggcgagctggatcaagatatgt
    Mapping_target: K12H4
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00035199
            Person_evidence: WBPerson315
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00040753
      WBStrain00040767
    Laboratory: GR
    Status: Live
  Affects: Gene: WBGene00000939
    Transcript: K12H4.8.1 (12)
  Genetics: Interpolated_map_position: III -0.385289
  Description: Phenotype: WBPhenotype:0000136 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
        Remark: mRNA levels of siRNA target genes are increased compared to control animals. This increase in mRNA levels include those for sperm-specific siRNA target gene ssp-19, C25G4.6, and F18C5.4, defining this gene as a class I Eri factor. Paper_evidence: WBPaper00035199
            Curator_confirmed: WBPerson712
      WBPhenotype:0000154 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
      WBPhenotype:0000390 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
        Remark: In vivo activation of spermatids was defective as spermatids failed to localize to the spermatheca. Paper_evidence: WBPaper00035199
            Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
        Remark: Animals are ts sterile. Paper_evidence: WBPaper00035199
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00035199
              Curator_confirmed: WBPerson712
      WBPhenotype:0000693 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
        Remark: Spermatids were unable to form pseudopods and exhibited aberrant morphology. Paper_evidence: WBPaper00035199
            Curator_confirmed: WBPerson712
      WBPhenotype:0000812 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
      WBPhenotype:0001175 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
      WBPhenotype:0001258 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
      WBPhenotype:0001776 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
        Remark: Animals fail to express endo siRNAs. Paper_evidence: WBPaper00035199
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000039 Paper_evidence: WBPaper00041520
        Curator_confirmed: WBPerson19150
      WBPhenotype:0000139 Paper_evidence: WBPaper00041520
        Curator_confirmed: WBPerson19150
      WBPhenotype:0001759 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
        Remark: Animals retain the ability to express this class of small regulatory RNAs. Paper_evidence: WBPaper00035199
            Curator_confirmed: WBPerson712
      WBPhenotype:0001779 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
        Remark: Animals retain the ability to express this class of small regulatory RNAs. Paper_evidence: WBPaper00035199
            Curator_confirmed: WBPerson712
  Reference: WBPaper00041184
    WBPaper00041520
    WBPaper00035199
  Method: Substitution_allele