WormBase Tree Display for Variation: WBVar00088809
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WBVar00088809 | Name | Public_name | md176 | |||||
---|---|---|---|---|---|---|---|---|
Sequence_details | SeqStatus | Pending_curation | ||||||
Variation_type | Allele | |||||||
Origin | Species | Caenorhabditis elegans | ||||||
Strain | WBStrain00026411 | |||||||
WBStrain00027329 | ||||||||
Laboratory | RM | |||||||
Status | Live | |||||||
Affects | Gene | WBGene00001179 | ||||||
Interactor | WBInteraction000524571 | |||||||
WBInteraction000524572 | ||||||||
WBInteraction000524575 | ||||||||
Description | Phenotype | WBPhenotype:0000017 | Paper_evidence | WBPaper00035198 | ||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00003650 | Paper_evidence | WBPaper00035198 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000022 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0000481 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
Remark | egl-10(md176) mutants were defective in the avoidance response to high osmotic strength (1 molar glycerol) compared to wild type controls (Figure 1a, 2a, Table 1). | Paper_evidence | WBPaper00037778 | |||||
Curator_confirmed | WBPerson2987 | |||||||
egl-10(md176) mutants were defective in the avoidance response to 10 millimolar quinine compared to wild type controls (Figure 1a, 2a). | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
egl-10(md176) mutants were defective in the avoidance response to 1 millimolar copper ions compared to wild type controls (Figure 1a). | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
egl-10(md176) mutants were defective in the avoidance response to 100% octanol compared to wild type controls (Figure 1b). | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
In a Psra-6::TRPV1 transgenic background (animals express rat TRPV1 in the ASH neuron and respond to capsaicin), egl-10(md176) mutants were defective in the avoidance response to 50 μM capsaicin compared to Psra-6::TRPV1-only transgenic controls (Table 1). | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
Rescued_by_transgene | WBTransgene00020539 | |||||||
WBTransgene00020540 | ||||||||
Affected_by | Molecule | WBMol:00003633 | Paper_evidence | WBPaper00037778 | ||||
Curator_confirmed | WBPerson2987 | |||||||
WBMol:00003904 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBMol:00002862 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBMol:00001966 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBMol:00003635 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
Phenotype_assay | Genotype | Psra-6::TRPV1 | Paper_evidence | WBPaper00037778 | ||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0000542 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0000545 | Paper_evidence | WBPaper00035489 | ||||||
Curator_confirmed | WBPerson2021 | |||||||
Remark | egl-10 mutants (with increased inhibitory Go signaling) accumulated far more eggs in utero than wild-type animals | Paper_evidence | WBPaper00035489 | |||||
Curator_confirmed | WBPerson2021 | |||||||
Variation_effect | Null | Paper_evidence | WBPaper00035489 | |||||
Curator_confirmed | WBPerson2021 | |||||||
WBPhenotype:0000631 | Paper_evidence | WBPaper00035198 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals exhibit anterior convulsions when treated with pentylenetetrazole(PTZ). | Paper_evidence | WBPaper00035198 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00004251 | Paper_evidence | WBPaper00035198 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000641 | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Dispersal index in the absence of anesthetic, ~0.50, is decreased compared to N2, ~0.90. | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Treatment | Dispersal assay as reported in Crowder et al.1996; van Swinderen et al. 1997. | Paper_evidence | WBPaper00004721 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001005 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0001482 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0001506 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
Remark | egl-10(md176) mutants exhibited a reduced spontaneous reversal rate, compared to wild type animals (Figure 5) | Paper_evidence | WBPaper00037778 | |||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0001639 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0001918 | Paper_evidence | WBPaper00041132 | ||||||
Curator_confirmed | WBPerson557 | |||||||
Remark | egl-10(md176) mutants are hypersensitive to the effects of exogenous dopamine on locomotion rate. | Paper_evidence | WBPaper00041132 | |||||
Curator_confirmed | WBPerson557 | |||||||
WBPhenotype:0002114 | Paper_evidence | WBPaper00041132 | ||||||
Curator_confirmed | WBPerson557 | |||||||
WBPhenotype:0002284 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002289 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002293 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002296 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002298 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002301 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002310 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002312 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002321 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002324 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002336 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0002347 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0004022 | Paper_evidence | WBPaper00043908 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
Phenotype_not_observed | WBPhenotype:0000017 | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Fraction of animals moving after exposure to 0.5mM aldicarb is ~0.026 compared to N2 ~0.03. | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00003650 | Paper_evidence | WBPaper00004721 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000315 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
Remark | egl-10(md176) mutants exhibited a wild type avoidance response to anterior body touch (Figure 1c) | Paper_evidence | WBPaper00037778 | |||||
Curator_confirmed | WBPerson2987 | |||||||
WBPhenotype:0001618 | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals exhibit an EC50 for halothane statistically insignificant from that of N2 as determined by a concentration-response curve based on animal dispersal indexes. | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | |||||||
Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00001705 | Paper_evidence | WBPaper00004721 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001619 | Paper_evidence | WBPaper00004721 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals exhibit an EC50 for isoflurane statistically insignificant from that of N2 as determined by a concentration-response curve based on animal dispersal indexes. | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | |||||||
Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00004721 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00004563 | Paper_evidence | WBPaper00004721 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0002077 | Paper_evidence | WBPaper00041132 | ||||||
Curator_confirmed | WBPerson557 | |||||||
Remark | egl-10(md176) mutants are hypersensitive to the effects of exogenous dopamine on locomotion rate. | Paper_evidence | WBPaper00041132 | |||||
Curator_confirmed | WBPerson557 | |||||||
WBPhenotype:0002199 | Paper_evidence | WBPaper00037778 | ||||||
Curator_confirmed | WBPerson2987 | |||||||
Remark | The egl-10(md176) mutation did not affect the calcium transients in ASH neurons in response to high osmolarity (1M glycerol) (Figure 4a), 10 millimolar quinine (Figure 4b), or 1 millimolar copper (Figure 4c) | Paper_evidence | WBPaper00037778 | |||||
Curator_confirmed | WBPerson2987 | |||||||
Reference | WBPaper00043908 | |||||||
WBPaper00035198 | ||||||||
WBPaper00015719 | ||||||||
WBPaper00004721 | ||||||||
WBPaper00035489 | ||||||||
WBPaper00037778 | ||||||||
WBPaper00041132 | ||||||||
WBPaper00065340 | ||||||||
Method | Allele |