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WormBase Tree Display for Variation: WBVar00088809

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Name Class

WBVar00088809NamePublic_namemd176
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00026411
WBStrain00027329
LaboratoryRM
StatusLive
AffectsGeneWBGene00001179
InteractorWBInteraction000524571
WBInteraction000524572
WBInteraction000524575
DescriptionPhenotypeWBPhenotype:0000017Paper_evidenceWBPaper00035198
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003650Paper_evidenceWBPaper00035198
Curator_confirmedWBPerson712
WBPhenotype:0000022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000481Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Remarkegl-10(md176) mutants were defective in the avoidance response to high osmotic strength (1 molar glycerol) compared to wild type controls (Figure 1a, 2a, Table 1).Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
egl-10(md176) mutants were defective in the avoidance response to 10 millimolar quinine compared to wild type controls (Figure 1a, 2a).Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
egl-10(md176) mutants were defective in the avoidance response to 1 millimolar copper ions compared to wild type controls (Figure 1a).Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
egl-10(md176) mutants were defective in the avoidance response to 100% octanol compared to wild type controls (Figure 1b).Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
In a Psra-6::TRPV1 transgenic background (animals express rat TRPV1 in the ASH neuron and respond to capsaicin), egl-10(md176) mutants were defective in the avoidance response to 50 μM capsaicin compared to Psra-6::TRPV1-only transgenic controls (Table 1).Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Rescued_by_transgeneWBTransgene00020539
WBTransgene00020540
Affected_byMoleculeWBMol:00003633Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBMol:00003904Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBMol:00002862Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBMol:00001966Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBMol:00003635Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Phenotype_assayGenotypePsra-6::TRPV1Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBPhenotype:0000542Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000545Paper_evidenceWBPaper00035489
Curator_confirmedWBPerson2021
Remarkegl-10 mutants (with increased inhibitory Go signaling) accumulated far more eggs in utero than wild-type animalsPaper_evidenceWBPaper00035489
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00035489
Curator_confirmedWBPerson2021
WBPhenotype:0000631Paper_evidenceWBPaper00035198
Curator_confirmedWBPerson712
RemarkAnimals exhibit anterior convulsions when treated with pentylenetetrazole(PTZ).Paper_evidenceWBPaper00035198
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004251Paper_evidenceWBPaper00035198
Curator_confirmedWBPerson712
WBPhenotype:0000641Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkDispersal index in the absence of anesthetic, ~0.50, is decreased compared to N2, ~0.90.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Phenotype_assayTreatmentDispersal assay as reported in Crowder et al.1996; van Swinderen et al. 1997.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0001005Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0001482Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0001506Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Remarkegl-10(md176) mutants exhibited a reduced spontaneous reversal rate, compared to wild type animals (Figure 5)Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBPhenotype:0001639Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0001918Paper_evidenceWBPaper00041132
Curator_confirmedWBPerson557
Remarkegl-10(md176) mutants are hypersensitive to the effects of exogenous dopamine on locomotion rate.Paper_evidenceWBPaper00041132
Curator_confirmedWBPerson557
WBPhenotype:0002114Paper_evidenceWBPaper00041132
Curator_confirmedWBPerson557
WBPhenotype:0002284Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002289Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002293Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002296Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002298Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002301Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002310Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002312Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002321Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002324Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002336Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002347Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0004022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000017Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkFraction of animals moving after exposure to 0.5mM aldicarb is ~0.026 compared to N2 ~0.03.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003650Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0000315Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Remarkegl-10(md176) mutants exhibited a wild type avoidance response to anterior body touch (Figure 1c)Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBPhenotype:0001618Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkAnimals exhibit an EC50 for halothane statistically insignificant from that of N2 as determined by a concentration-response curve based on animal dispersal indexes.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001705Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0001619Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkAnimals exhibit an EC50 for isoflurane statistically insignificant from that of N2 as determined by a concentration-response curve based on animal dispersal indexes.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004563Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0002077Paper_evidenceWBPaper00041132
Curator_confirmedWBPerson557
Remarkegl-10(md176) mutants are hypersensitive to the effects of exogenous dopamine on locomotion rate.Paper_evidenceWBPaper00041132
Curator_confirmedWBPerson557
WBPhenotype:0002199Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
RemarkThe egl-10(md176) mutation did not affect the calcium transients in ASH neurons in response to high osmolarity (1M glycerol) (Figure 4a), 10 millimolar quinine (Figure 4b), or 1 millimolar copper (Figure 4c)Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
ReferenceWBPaper00043908
WBPaper00035198
WBPaper00015719
WBPaper00004721
WBPaper00035489
WBPaper00037778
WBPaper00041132
WBPaper00065340
MethodAllele