WormBase Tree Display for Variation: WBVar00088469

WBVar00088469 Evidence: Paper_evidence: WBPaper00035405
  Name: Public_name: ky756
    Other_name: W01B6.1.1:c.464G>A
      CE03753:p.Trp155Ter
    HGVSg: CHROMOSOME_IV:g.10068640G>A
  Sequence_details: SMap: S_parent: Sequence: W01B6
    Flanking_sequences: aaaccaaaaaatgttccaacagattggagtt gggtggatgtggagataatgttgaatatggt
    Mapping_target: W01B6
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00035405
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00005286
      WBStrain00005287
      WBStrain00005288
      WBStrain00005289
      WBStrain00005290
      WBStrain00005291
      WBStrain00005295
      WBStrain00005319
      WBStrain00005320
    Laboratory: CX
    Status: Live
  Affects: Gene: WBGene00000858
    Transcript: W01B6.1.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: W01B6.1.1:c.464G>A
        HGVSp: CE03753:p.Trp155Ter
        cDNA_position: 523
        CDS_position: 464
        Protein_position: 155
        Exon_number: 4/8
        Codon_change: tGg/tAg
        Amino_acid_change: W/*
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: IV 4.48165
  Description: Phenotype: WBPhenotype:0000071 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: Head shape was slightly distorted Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000384 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: In many cwn-2 animals, ceh-24::GFP-expressing axons made abnormal excursions anterior of the nerve ring. SIA and SIB neurons had guidance errors at multiple positions Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000491 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: The isthmus of the cwn-2 mutant pharynx was slightly shorter and thicker than normal Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000540 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: The muscle arms in cwn-2 mutants joined the nerve ring at its abnormal anterior position Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000883 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: cwn-2 mutants had anteriorly displaced nerve rings: the nerve ring circled the metacorpus of the pharynx instead of its usual location around the isthmus of the pharynx Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000899 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: The nuclei of epithelial cells were slightly disorganized in placement Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000904 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: The nuclei of muscle cells were slightly disorganized in placement Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000917 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: The excretory duct was shifted anteriorly in the cwn-2 mutant Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001310 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: Neuronal cell bodies anterior and posterior of the nerve ring were anteriorly misplaced Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000632 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: Axon defasciculation was not observed in cwn-2 mutants Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001510 Paper_evidence: WBPaper00035405
        Curator_confirmed: WBPerson2021
        Remark: SIA and SIB markers (ceh-24, cam-1 and mig-1) were expressed normally in cwn-2 mutants Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035405
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00035405
            Curator_confirmed: WBPerson2021
  Reference: WBPaper00035405
  Method: Substitution_allele