WormBase Tree Display for Variation: WBVar00088092

WBVar00088092 Name: Public_name: jh103
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00023526
    Laboratory: KJ
    Status: Live
  Affects: Gene: WBGene00000554
    Interactor: WBInteraction000501864
      WBInteraction000502704
      WBInteraction000502706
      WBInteraction000502708
      WBInteraction000504756
  Genetics: Mapping_data: In_multi_point: 4230
  Description: Phenotype: WBPhenotype:0000231 Paper_evidence: WBPaper00031862
        Curator_confirmed: WBPerson712
        Remark: Body volume is lower than N2 animals. Paper_evidence: WBPaper00031862
            Curator_confirmed: WBPerson712
        Dominant: Paper_evidence: WBPaper00031862
          Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00031862
            Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20 Paper_evidence: WBPaper00031862
              Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00049950
        Curator_confirmed: WBPerson3637
        Remark: enhancement of TDP-43 transgenic phenotypes Paper_evidence: WBPaper00049950
            Curator_confirmed: WBPerson3637
        Phenotype_assay: Genotype: [Psnb-1::hTDP-43] Paper_evidence: WBPaper00049950
              Curator_confirmed: WBPerson3637
      WBPhenotype:0000673 Paper_evidence: WBPaper00031862
        Curator_confirmed: WBPerson712
        Remark: Animals have lowered brood size than N2 (n=50-60). Paper_evidence: WBPaper00031862
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00031862
            Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20 Paper_evidence: WBPaper00031862
              Curator_confirmed: WBPerson712
      WBPhenotype:0001068 Paper_evidence: WBPaper00031862
        Curator_confirmed: WBPerson712
        Remark: Animals lay a smaller number of eggs in response to serotonin than wild-type worms. Based on the percentage of worms laying eggs in response to 12.5 mM serotonin (n=50-60). Paper_evidence: WBPaper00031862
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00031862
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004929 Paper_evidence: WBPaper00031862
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20 Paper_evidence: WBPaper00031862
              Curator_confirmed: WBPerson712
      WBPhenotype:0001339 Paper_evidence: WBPaper00031862
        Curator_confirmed: WBPerson712
        Remark: Animals exhibit strong resistance to levamisole compared to N2. Based on the percentage of worms laying eggs in response to 12.5 mM levamisole (n=50-60). Paper_evidence: WBPaper00031862
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00031862
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00031862
              Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20 Paper_evidence: WBPaper00031862
              Curator_confirmed: WBPerson712
      WBPhenotype:0001524 Paper_evidence: WBPaper00035944
        Curator_confirmed: WBPerson2776
          WBPerson10038
        Remark: Quoted from paper: " Interestingly, the decrease in the fraction of worms in quiescence exhibited by cnb-1(jh103) and tax- 6(db60) animals after approximately 90 minutes of the assay (Additional File 2) suggested distinct mechanisms underlying quiescence in the first and second phase of swimming." Paper_evidence: WBPaper00035944
            Curator_confirmed: WBPerson10038
      WBPhenotype:0001734 Paper_evidence: WBPaper00033168
        Curator_confirmed: WBPerson2021
        Remark: The rate of pharyngeal pumping off food was significantly elevated in the cnb-1 strains in comparison to control Paper_evidence: WBPaper00033168
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001765 Paper_evidence: WBPaper00031936
        Curator_confirmed: WBPerson2021
        Remark: Acute CO2 avoidance is eliminated Paper_evidence: WBPaper00031936
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00031936
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 10% CO2 Paper_evidence: WBPaper00031936
              Curator_confirmed: WBPerson2021
      WBPhenotype:0002114 Paper_evidence: WBPaper00035944
        Curator_confirmed: WBPerson2776
      WBPhenotype:0002380 Paper_evidence: WBPaper00049950
        Curator_confirmed: WBPerson3637
        Remark: enhancement of TDP-43 transgenic phenotypes Paper_evidence: WBPaper00049950
            Curator_confirmed: WBPerson3637
        Phenotype_assay: Genotype: [Psnb-1::hTDP-43] Paper_evidence: WBPaper00049950
              Curator_confirmed: WBPerson3637
  Reference (12)
  Method: Allele