WormBase Tree Display for Variation: WBVar00087745

WBVar00087745 Name: Public_name: hc4
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00000360
      WBStrain00000372
    Laboratory: BA
    Status: Live
  Affects: Gene: WBGene00001417
  Genetics: Mapping_data: In_multi_point: 226
  Description: Phenotype: WBPhenotype:0000291 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: no oocyte production, no rescue by wild-type sperm. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000357 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: At the permissive temperature, ts mutants produced 100 to 200 progeny; however, this mutant is somewhat sterile even at 16" as 38% of its oocytes were not fertilized. At the restrictive temperature of 25 deg C, animals produced only a few progeny. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
      WBPhenotype:0000387 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: hermaphrodites and males grown at 25C produce nonfunctional nonmotile sperm with aberrant pseudopods, perinuclear tubules. Skewed transmission ratio from hc4/+ males, implying haplo-expression. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Ease_of_scoring: ES2_Difficult_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000388 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: fer-4 male spermatozoa extend pseudopods of normal length but of irregular shapes. These pseudopods are fewere and have smaller projections than those in the wild type. The pseudopods of fer-4 spermatozoa also fail to exhibit any ruffling movement and the cells do not translocate in vitro. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: At the permissive temperature, ts mutants produced 100 to 200 progeny; however, this mutant is somewhat sterile even at 16" as 38% of its oocytes were not fertilized. At the restrictive temperature of 25 deg C, animals produced only a few progeny. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
      WBPhenotype:0000691 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: hc4/Df hermaphrodites have abnormal gonads with no oocyte production, no rescue by wild-type sperm. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000693 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
      WBPhenotype:0000806 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: Animals are fertilization defective. Animals have a long (24 hr) temperature sensitive period (TSP). Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
      WBPhenotype:0000863 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: Males are ts sterile, producing less progeny at restrictive temperatures. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
          Mating of fertile dpy-11 hermaphrodites with sterile fer males or with permissively grown males did not reduce hermaphrodite self-fertilization, whereas mating with wild-type males did. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
      WBPhenotype:0001386 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Self-fertility 3% (25C) 50% (16C). No rescue by wild-type sperm. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0001720 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: Nonfunctional sperm of fer hermaphrodites are progressively lost fro the spermathecae of mutant hermaphrodites. by the time 40-70 oocytes have passed through the spermathecae of sterile hermaphrodites, most of the sperm have been swept out rather than migrating back through the spermathecal valve. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000495
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000033 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: Animals grow and develop at the same rate as wild type, initiating egg laying at 45 hr post-hatching, as do N2 hermaphrodites. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
      WBPhenotype:0000186 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: Oocytes are produced and are capable of being fertilized. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
      WBPhenotype:0000284 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: Sperm were transferred during copulation. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
      WBPhenotype:0000670 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: At the start of their egg-laying period, 45 hr post-hatching at 25 deg C, the spermathecae of these hermaphrodites contain over 170 sperm. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
      WBPhenotype:0000676 Paper_evidence: WBPaper00000495
        Curator_confirmed: WBPerson712
        Remark: Animals grow and develop at the same rate as wild type, initiating egg laying at 45 hr post-hatching, as do N2 hermaphrodites. Paper_evidence: WBPaper00000495
            Curator_confirmed: WBPerson712
  Reference: WBPaper00000495
    WBPaper00015949
  Method: Allele