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WormBase Tree Display for Variation: WBVar00087744

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Name Class

WBVar00087744EvidencePaper_evidenceWBPaper00044616
NamePublic_namehc3
Other_nameCE32072:p.Ser69Pro
W09B6.3a.1:c.205T>C
HGVSgCHROMOSOME_II:g.1123959T>C
Sequence_detailsSMapS_parentSequenceW09B6
Flanking_sequencestttcaggattccggcattcattttatcttccaaaagccacgtgtatacaatatccgtcaa
Mapping_targetW09B6
Type_of_mutationSubstitutiontcPaper_evidenceWBPaper00044616
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000359
LaboratoryBA
StatusLive
AffectsGeneWBGene00021103
TranscriptW09B6.3a.1VEP_consequencemissense_variant
VEP_impactMODERATE
HGVScW09B6.3a.1:c.205T>C
HGVSpCE32072:p.Ser69Pro
cDNA_position207
CDS_position205
Protein_position69
Exon_number4/13
Codon_changeTca/Cca
Amino_acid_changeS/P
GeneticsInterpolated_map_positionII-15.5661
Mapping_dataIn_multi_point199
DescriptionPhenotypeWBPhenotype:0000357Paper_evidenceWBPaper00001075
WBPaper00000495
Curator_confirmedWBPerson2021
WBPerson712
RemarkAt the permissive temperature, ts mutants produced 100 to 300 progeny and less than 65 unfertilized eggs, which were laid late in the life cycle, like those of wild-type hermaphrodites. At the restrictive temperature of 25 deg C, animals produced only a few progeny and laid 72 to 282 unfertilized eggs.Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
25Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
WBPhenotype:0000387Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkhermaphrodites and males grown at 25C produce nonfunctional nonmotile sperm with some aberrant pseudopods perinuclear tubules. TSP L3- L4.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES2_Difficult_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000688Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
RemarkAt the permissive temperature, ts mutants produced 100 to 300 progeny and less than 65 unfertilized eggs, which were laid late in the life cycle, like those of wild-type hermaphrodites. At the restrictive temperature of 25 deg C, animals produced only a few progeny and laid 72 to 282 unfertilized eggs.Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
WBPhenotype:0000693Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
WBPhenotype:0000806Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
RemarkAnimals are fertilization defective. Animals have a long (24 hr) temperature sensitive period (TSP).Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
WBPhenotype:0000863Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
RemarkMales are ts sterile, producing less progeny at restrictive temperatures.Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
Mating of fertile dpy-11 hermaphrodites with sterile fer males or with permissively grown males did not reduce hermaphrodite self-fertilization, whereas mating with wild-type males did.Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
WBPhenotype:0000983Paper_evidenceWBPaper00044616
Curator_confirmedWBPerson602
Remarkfer-3(hc3) fails to complement the Fer and Eri phenotypes of eri-3(tm1361).Paper_evidenceWBPaper00044616
Curator_confirmedWBPerson602
WBPhenotype:0001258Paper_evidenceWBPaper00044616
Curator_confirmedWBPerson602
Remarkfer-3(hc3) fails to complement the Fer and Eri phenotypes of eri-3(tm1361).Paper_evidenceWBPaper00044616
Curator_confirmedWBPerson602
WBPhenotype:0001360Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00001075
Curator_confirmedWBPerson2021
WBPhenotype:0001386Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkSelf-fertility = 1% (25C) 60% (16C).Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001720Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
RemarkNonfunctional sperm of fer hermaphrodites are progressively lost fro the spermathecae of mutant hermaphrodites. by the time 40-70 oocytes have passed through the spermathecae of sterile hermaphrodites, most of the sperm have been swept out rather than migrating back through the spermathecal valve. fer-3 mutants lose sperm at a faster rate than other fer mutants.Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000033Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
RemarkAnimals grow and develop at the same rate as wild type, initiating egg laying at 45 hr post-hatching, as do N2 hermaphrodites.Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
WBPhenotype:0000186Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
RemarkOocytes are produced and are capable of being fertilized.Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
WBPhenotype:0000284Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
RemarkSperm were transferred during copulation.Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
WBPhenotype:0000670Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
RemarkAt the start of their egg-laying period, 45 hr post-hatching at 25 deg C, the spermathecae of these hermaphrodites contain over 170 sperm.Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
WBPhenotype:0000676Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
RemarkAnimals grow and develop at the same rate as wild type, initiating egg laying at 45 hr post-hatching, as do N2 hermaphrodites.Paper_evidenceWBPaper00000495
Curator_confirmedWBPerson712
ReferenceWBPaper00001075
WBPaper00000495
WBPaper00015949
WBPaper00044616
MethodSubstitution_allele