WormBase Tree Display for Variation: WBVar00000654

WBVar00000654 Evidence: Paper_evidence: WBPaper00004880
  Name: Public_name: bz29
    Other_name: CE21562:p.Trp28Ter
      Y38A10A.5.1:c.83G>A
    HGVSg: CHROMOSOME_V:g.6100427C>T
  Sequence_details: SMap: S_parent: Sequence: Y38A10A
    Flanking_sequences: acttcaaagaggagttcaacgacgcctcat ggagaagcgatgggttcaatccaagcacaa
    Mapping_target: Y38A10A
    Type_of_mutation: Substitution: g a
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00040781
    Laboratory: ZB
    Status: Live
  Affects: Gene: WBGene00000802
    Transcript: Y38A10A.5.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: Y38A10A.5.1:c.83G>A
        HGVSp: CE21562:p.Trp28Ter
        cDNA_position: 116
        CDS_position: 83
        Protein_position: 28
        Exon_number: 2/5
        Codon_change: tGg/tAg
        Amino_acid_change: W/*
    Interactor: WBInteraction000501716
      WBInteraction000571514
      WBInteraction000571524
  Genetics: Interpolated_map_position: V -0.352787
  Description: Phenotype: WBPhenotype:0002606 Paper_evidence: WBPaper00041673
        Curator_confirmed: WBPerson2987
        Remark: "Likewise, loss of crt-1, cnx-1, itr-1, clp-1, tra-3, asp-3, or asp-4 partially suppressed HBx-induced cell killing (from 50% to 12-32% PLM death; Fig. 2A), indicating that HBx induces cell death in part through the necrotic pathway." Paper_evidence: WBPaper00041673
            Curator_confirmed: WBPerson2987
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00041673
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: smIs98 [Pmec-3::GFP; Pmec-7::HBx] Paper_evidence: WBPaper00041673
              Curator_confirmed: WBPerson2987
  Reference: WBPaper00029017
    WBPaper00022915
    WBPaper00041673
  Method: Substitution_allele