WormBase Tree Display for Variation: WBVar00088387

WBVar00088387 Evidence: Paper_evidence: WBPaper00002930
  Name: Public_name: ky10
    Other_name: B0212.5.1:c.517C>T
      CE20445:p.Gln173Ter
    HGVSg: CHROMOSOME_IV:g.3556045G>A
  Sequence_details: SMap: S_parent: Sequence: B0212
    Flanking_sequences: GCGGCCTGAAACATTGTGTTATCTTTAGGC AATCAGCCCTCCACCTAGCCATTGTACACG
    Mapping_target: B0212
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00002930
            Person_evidence: WBPerson40923
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00005214
      WBStrain00007483
      WBStrain00052609
    Laboratory: CX
    Status: Live
  Affects: Gene: WBGene00003889
    Transcript: B0212.5.1 VEP_consequence: stop_gained,splice_region_variant
        VEP_impact: HIGH
        HGVSc: B0212.5.1:c.517C>T
        HGVSp: CE20445:p.Gln173Ter
        cDNA_position: 517
        CDS_position: 517
        Protein_position: 173
        Exon_number: 5/15
        Codon_change: Caa/Taa
        Amino_acid_change: Q/*
    Interactor (17)
  Genetics: Interpolated_map_position: IV -3.15548
  Description: Phenotype (34)
    Phenotype_not_observed: WBPhenotype:0000302 Paper_evidence: WBPaper00002930
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00002930
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 1:200 dilution of benzaldehyde Paper_evidence: WBPaper00002930
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000304 Paper_evidence: WBPaper00002930
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00002930
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 1:100 dilution of isoamyl alcohol Paper_evidence: WBPaper00002930
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000306 Paper_evidence: WBPaper00002930
        Curator_confirmed: WBPerson2021
        Remark: AWA specific expression of odr-7::GFP is unaltered in osm-9 mutants Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00002930
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: kyIs38 Paper_evidence: WBPaper00002930
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000398 Paper_evidence: WBPaper00002930
        Curator_confirmed: WBPerson2021
        Remark: Mutants respond to stroking to the body with a hair Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00002930
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000481 Paper_evidence: WBPaper00065019
        Curator_confirmed: WBPerson712
        Remark (2)
        Affected_by: Molecule: WBMol:00008002 Paper_evidence: WBPaper00065019
              Curator_confirmed: WBPerson712
            WBMol:00008001 Paper_evidence: WBPaper00065019
              Curator_confirmed: WBPerson712
      WBPhenotype:0000630 Paper_evidence: WBPaper00035961
        Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003904 Paper_evidence: WBPaper00035961
              Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005665 PATO:0000460 Paper_evidence: WBPaper00035961
                Curator_confirmed: WBPerson712
      WBPhenotype:0000905 Paper_evidence: WBPaper00002930
        Curator_confirmed: WBPerson2021
        Remark: The morphology of AWA and ASH neurons is normal Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00002930
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005670 PATO:0000460 Paper_evidence: WBPaper00002930
                Curator_confirmed: WBPerson2021
            WBbt:0005665 PATO:0000460 Paper_evidence: WBPaper00002930
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001084 Paper_evidence: WBPaper00005150
        Curator_confirmed: WBPerson48
        Phenotype_assay: Treatment: Chemotaxis assay for a 10 minute timepoint. Paper_evidence: WBPaper00005150
              Curator_confirmed: WBPerson48
      WBPhenotype:0001085 Paper_evidence: WBPaper00002930
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00002930
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 1:1000 dilution of butanone Paper_evidence: WBPaper00002930
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001086 Paper_evidence: WBPaper00002930
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00002930
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00002930
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 1:1000 dilution of trimethylthiazole Paper_evidence: WBPaper00002930
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001435 Paper_evidence: WBPaper00005150
        Curator_confirmed: WBPerson48
        Phenotype_assay: Treatment: Chemotaxis assay for a 10 minute timepoint. Paper_evidence: WBPaper00005150
              Curator_confirmed: WBPerson48
      WBPhenotype:0001442 Paper_evidence: WBPaper00005150
        Curator_confirmed: WBPerson48
        Phenotype_assay: Treatment: Chemotaxis assay for a 10 minute timepoint. Paper_evidence: WBPaper00005150
              Curator_confirmed: WBPerson48
      WBPhenotype:0001454 Paper_evidence: WBPaper00059946
        Curator_confirmed: WBPerson712
        Remark: Individual loss of neither OSM-9 nor OCR-2 function affected response to 10mM quinine (Figure 1A), similar to our previous report (Ezak et al. 2010). Further, osm-9 and ocr-2 single mutants responded similarly to wild-type animals across the range of quinine concentrations tested (10mM - 1mM, Figure 1A). Paper_evidence: WBPaper00059946
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003904 Paper_evidence: WBPaper00059946
              Curator_confirmed: WBPerson712
      WBPhenotype:0001469 Paper_evidence: WBPaper00032215
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited attraction to butanone similar to wild-type animals. Paper_evidence: WBPaper00032215
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00005086 Paper_evidence: WBPaper00032215
              Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005665 PATO:0000460 Paper_evidence: WBPaper00032215
                Curator_confirmed: WBPerson712
            WBbt:0005661 PATO:0000460 Paper_evidence: WBPaper00032215
                Curator_confirmed: WBPerson712
      WBPhenotype:0001484 Paper_evidence: WBPaper00005150
        Curator_confirmed: WBPerson48
        Phenotype_assay: Treatment: Chemotaxis assay for a 10 minute timepoint. Paper_evidence: WBPaper00005150
              Curator_confirmed: WBPerson48
      WBPhenotype:0001741 Paper_evidence: WBPaper00032000
        Curator_confirmed: WBPerson712
        Remark: <10% males displayed spontaneous spicule-muscle seizures in the presence or absence of food. Paper_evidence: WBPaper00032000
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005826 PATO:0000460 Paper_evidence: WBPaper00032000
                Curator_confirmed: WBPerson712
            WBbt:0005312 PATO:0000460 Paper_evidence: WBPaper00032000
                Curator_confirmed: WBPerson712
          Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00032000
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: To effect food deprivation animals were moved to plates with no food (E. coli) or fed inedible bacteria (aztreonam-treated E. coli). Paper_evidence: WBPaper00032000
              Curator_confirmed: WBPerson712
      WBPhenotype:0001765 Paper_evidence: WBPaper00031935
          WBPaper00031936
        Curator_confirmed: WBPerson712
          WBPerson2021
        Remark (2)
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00031936
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Strains were maintained at 22C. Animals were exposed to a 5% to 0% CO2 gradient. Paper_evidence: WBPaper00031935
              Curator_confirmed: WBPerson712
            10% CO2 Paper_evidence: WBPaper00031936
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001780 Paper_evidence: WBPaper00029060
        Curator_confirmed: WBPerson2021
        Remark: Mutants show normal butanone enhancement Paper_evidence: WBPaper00029060
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00029060
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Preexposure to 1:10 dilution of butanone and food. Animals were then subjected to odorant chemotaxis assays and/or selection assays Paper_evidence: WBPaper00029060
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001939 Paper_evidence: WBPaper00035961
        Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003731 Paper_evidence: WBPaper00035961
              Curator_confirmed: WBPerson712
            WBMol:00003904 Paper_evidence: WBPaper00035961
              Curator_confirmed: WBPerson712
            WBMol:00003565 Paper_evidence: WBPaper00035961
              Curator_confirmed: WBPerson712
            WBMol:00001530 Paper_evidence: WBPaper00035961
              Curator_confirmed: WBPerson712
            WBMol:00005022 Paper_evidence: WBPaper00035961
              Curator_confirmed: WBPerson712
  Reference (25)
  Remark: Manually curated Gene associations preserved as a text remark so that VEP is the canonical predictor of consequence: WBGene00003889 Ochre_UAA Q(173) to stop Paper_evidence: WBPaper00002930
  Method: Substitution_allele