WormBase Tree Display for Variation: WBVar00143071

WBVar00143071 Name: Public_name: e262
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00003969
      WBStrain00003971
      WBStrain00004138
      WBStrain00047362
    Laboratory: CB
    Status: Live
  Affects (2)
  Genetics: Mapping_data: In_2_point: 15
      In_multi_point (20)
      In_pos_neg_data (37)
  Description: Phenotype: WBPhenotype:0000164 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0000324 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0000565 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: weak coiler; phenotype similar to Unc-4 Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES2_Difficult_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000641 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: fairly active Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00000031
        Curator_confirmed: WBPerson48
      WBPhenotype:0000688 Paper_evidence: WBPaper00002829
        Curator_confirmed: WBPerson712
        Remark: sterile adult mutants had a normal life-span of two to three weeks and grew to the expected size for Unc-13 adults (0.6+/-0.8 mm) Paper_evidence: WBPaper00002829
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00002829
          Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00002829
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: dpy-5 unc-13; sDp2 Paper_evidence: WBPaper00002829
              Curator_confirmed: WBPerson712
      WBPhenotype:0001510 Paper_evidence: WBPaper00036225
        Curator_confirmed: WBPerson2021
        Remark: Misspecification of a specific class of ventral cord motorneurons: Mutants show ectopic expression of the wdIs3 (del-1::gfp) reporter in the presumptive VA motoneurons. The reporter is expressed only in the VB motoneurons in wildtype animals at the L2 stage. Paper_evidence: WBPaper00036225
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00036225
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005300 PATO:0000460 Paper_evidence: WBPaper00036225
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001660 Paper_evidence: WBPaper00006052
          WBPaper00036225
        Curator_confirmed: WBPerson2021
        Remark: ASE asymmetry is disrupted (as seen with lim-6, gcy-5 and gcy-7 reporters). 2 ASEL Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
          Lsy phenotype - 2ASEL Paper_evidence: WBPaper00036225
            Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: Paper_evidence: WBPaper00006052
              Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00006052
              WBPaper00036225
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005663 PATO:0000460 Paper_evidence: WBPaper00006052
                Curator_confirmed: WBPerson2021
            WBbt:0003903 PATO:0000460 Paper_evidence: WBPaper00036225
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00006052
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: otIs6, otIs114,otIs3, ntIs1 Paper_evidence: WBPaper00006052
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001716 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002284 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002288 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002293 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002295 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002300 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002301 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002310 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002312 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002323 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002328 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002336 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002344 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002345 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0004023 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
    Phenotype_not_observed (4)
  Reference (26)
  Method: Allele