WormBase Tree Display for Variation: WBVar00089847
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| WBVar00089847 | Name | Public_name | n945 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sequence_details | SeqStatus | Pending_curation | |||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Strain | WBStrain00004580 | ||||||||
| WBStrain00004821 | |||||||||
| WBStrain00026916 | |||||||||
| WBStrain00027011 | |||||||||
| WBStrain00027284 | |||||||||
| WBStrain00027285 | |||||||||
| WBStrain00027286 | |||||||||
| Laboratory | MT | ||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00001174 | |||||||
| Interactor | WBInteraction000008559 | ||||||||
| WBInteraction000524137 | |||||||||
| WBInteraction000524139 | |||||||||
| WBInteraction000535394 | |||||||||
| WBInteraction000555479 | |||||||||
| Genetics | Mapping_data | In_multi_point | 1398 | ||||||
| 1400 | |||||||||
| 1404 | |||||||||
| 1886 | |||||||||
| In_pos_neg_data | 4976 | ||||||||
| Description | Phenotype | WBPhenotype:0000006 | Paper_evidence | WBPaper00001133 | |||||
| WBPaper00001105 | |||||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | egl-5 hermaphrodites either lack or have misplaced HSNs | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Penetrance | Complete | Paper_evidence | WBPaper00001133 | ||||||
| WBPaper00001105 | |||||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Range | 100 | 100 | Paper_evidence | WBPaper00001133 | |||||
| WBPaper00001105 | |||||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Recessive | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00001133 | ||||
| WBPaper00001105 | |||||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Temperature | 20 | Paper_evidence | WBPaper00001133 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0000070 | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Recessive | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00001133 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Genotype | him-5(e1490) | Paper_evidence | WBPaper00001133 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0000093 | Paper_evidence | WBPaper00031910 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals produce extra HSNs and PHBs. | Paper_evidence | WBPaper00031910 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Variation_effect | Probable_null_via_phenotype | Paper_evidence | WBPaper00031910 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0007808 | PATO:0000460 | Paper_evidence | WBPaper00031910 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBbt:0006830 | PATO:0000460 | Paper_evidence | WBPaper00031910 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Genotype | gmIs13 | Paper_evidence | WBPaper00031910 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000154 | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | Mutants show a 50 percent drop in brood size (compared to wild-type) | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Recessive | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00001133 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Temperature | 20 | Paper_evidence | WBPaper00001133 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0000199 | Paper_evidence | WBPaper00004616 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | "Whereas in mab-5(e1239), descendants of V6 generate alae instead of rays in 100% of animals, in sop-3(bx96); mab-5(e1239) double mutants, 14% of male sides lacked alae in the post-anal region, and these males generated an average of 1.5 V6 rays per suppressed side (Table 2, line 3). Generation of these mab-5-independent rays required the function of egl-5 because in sop-3(bx96); mab-5(e1239) egl-5(n945) there were no V5 or V6 rays and alae extended into the tail region in all sides (Table 2, line 5)." | Paper_evidence | WBPaper00004616 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term (11) | ||||||||
| Phenotype_assay | Genotype | sop-3(bx96); mab-5(e1239) | Paper_evidence | WBPaper00004616 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0000316 | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Recessive | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0000339 | Person_evidence | WBPerson261 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | strongest allele | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000354 | Paper_evidence | WBPaper00001105 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | HSN maturation is abnormal. No hood formation and nucleolar growth is observed | Paper_evidence | WBPaper00001105 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006830 | PATO:0000460 | Paper_evidence | WBPaper00001105 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Life_stage | WBls:0000038 | PATO:0000460 | Paper_evidence | WBPaper00001105 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0000414 | Paper_evidence | WBPaper00003135 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | egl-5(n945) resulted in a completely penetrant P12 to P11 cell fate transformation (Table 1B) | Paper_evidence | WBPaper00003135 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Penetrance | Complete | Paper_evidence | WBPaper00003135 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Rescued_by_transgene | WBTransgene00006875 | ||||||||
| Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00003135 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0004410 | PATO:0000460 | Paper_evidence | WBPaper00003135 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBbt:0004409 | PATO:0000460 | Paper_evidence | WBPaper00003135 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0000425 | Paper_evidence | WBPaper00001105 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | Serotonin levels are reduced in HSNs (determined immunocytochemically). | Paper_evidence | WBPaper00001105 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006830 | PATO:0000460 | Paper_evidence | WBPaper00001105 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00001105 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0000470 | Paper_evidence | WBPaper00001105 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | HSNs fail to arrive at their final destination (between P5/6 and V4) | Paper_evidence | WBPaper00001105 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006830 | PATO:0000460 | Paper_evidence | WBPaper00001105 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Life_stage | WBls:0000024 | PATO:0000460 | Paper_evidence | WBPaper00001105 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0000565 | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Recessive | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0001219 | Paper_evidence | WBPaper00001105 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | In n945 males, the HSNs (which normally undergo apoptosis) survive. Data not shown | Paper_evidence | WBPaper00001105 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Penetrance | Incomplete | Paper_evidence | WBPaper00001105 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Range | 40 | 40 | Paper_evidence | WBPaper00001105 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006830 | PATO:0000460 | Paper_evidence | WBPaper00001105 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00001105 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0001340 | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | See Table 1 | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Penetrance | Incomplete | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Range | 58 | 58 | Paper_evidence | WBPaper00001133 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Recessive | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00001133 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay (2) | |||||||||
| WBPhenotype:0001414 | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | male mating is completely abolished | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Penetrance | High | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Recessive | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00001133 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Genotype | him-5(e1490) | Paper_evidence | WBPaper00001133 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_not_observed | WBPhenotype:0001068 | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Recessive | Paper_evidence | WBPaper00001133 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00001133 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00001133 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay (2) | |||||||||
| WBPhenotype:0001645 | Paper_evidence | WBPaper00040284 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | Table 1 | Paper_evidence | WBPaper00040284 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Reference (11) | |||||||||
| Method | Allele |
