WormBase Tree Display for Variation: WBVar00089206
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| WBVar00089206 | Name | Public_name | mu71 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sequence_details | SeqStatus | Pending_curation | |||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Strain | WBStrain00004822 | ||||||||
| Laboratory | CF | ||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00003246 | |||||||
| Interactor | WBInteraction000000781 | ||||||||
| WBInteraction000500063 | |||||||||
| WBInteraction000517368 | |||||||||
| WBInteraction000517369 | |||||||||
| WBInteraction000517376 | |||||||||
| WBInteraction000520379 | |||||||||
| WBInteraction000524019 | |||||||||
| WBInteraction000524381 | |||||||||
| Genetics | Mapping_data | In_multi_point | 3303 | ||||||
| Description | Phenotype | WBPhenotype:0000006 | Paper_evidence | WBPaper00004408 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | Table 3 | Paper_evidence | WBPaper00004408 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Penetrance | Incomplete | 28% penetrant | Paper_evidence | WBPaper00004408 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0000070 | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals exhibit defects in the formation of the hook and in the organization of the spicules. | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | High | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Recessive | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00002582 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000199 | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Male tails have few rays, rays that are present have abnormal morphology; unlike mab-5 mutants, these rays are not replaced with alae (data not shown). | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | High | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Recessive | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00002582 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000296 | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Spicules were often crumpled. | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | High | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Recessive | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00002582 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000414 | Paper_evidence | WBPaper00004408 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | Animals exhibit two large P11.p-like hypodermal nuclei immediately anterior to the anus, indicating a P12 to P11 cell-fate transformation (Table 3) | Paper_evidence | WBPaper00004408 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Penetrance | Low | 6% penetrant | Paper_evidence | WBPaper00004408 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006899 | PATO:0000460 | Paper_evidence | WBPaper00004408 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBbt:0006900 | PATO:0000460 | Paper_evidence | WBPaper00004408 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0000425 | Paper_evidence | WBPaper00003383 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | mig-14(mu71) results in a complete loss of mab-5 expression in the QL neuroblast, as determined by anti-MAB-5 antibody staining (Table 1). | Paper_evidence | WBPaper00003383 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations (2) | |||||||||
| WBPhenotype:0000469 | Paper_evidence | WBPaper00002582 | |||||||
| WBPaper00003383 | |||||||||
| Person_evidence | WBPerson261 | ||||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPerson2987 | |||||||||
| Remark | Although the migration of QL is posterior, QL descendants reverse direction during migration and migrate anteriorly. The final position of QL.pa daughters were displaced anteriorly compared to controls. | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| QL descendants migrate to anterior, QR descendants have shortened migrations. | Person_evidence | WBPerson261 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| mig-14(mu71) results in 0% of descendants of the QL neuroblast in the posterior of the animal, where the cell migrates in wild type (Table 1). | Paper_evidence | WBPaper00003383 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Penetrance | High | 95% | Paper_evidence | WBPaper00002582 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| Recessive | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations (2) | |||||||||
| WBPhenotype:0000470 | Paper_evidence | WBPaper00031356 | |||||||
| Person_evidence | WBPerson261 | ||||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | HSNs are displaced posteriorly (n=46). | Paper_evidence | WBPaper00031356 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| HSNs have shortened migrations | Person_evidence | WBPerson261 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | Complete | Paper_evidence | WBPaper00031356 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00031356 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006830 | PATO:0000460 | Paper_evidence | WBPaper00031356 | ||||
| Person_evidence | WBPerson261 | ||||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Treatment | HSNs were scored by Nomarski in newly hatched L1s and L1s 10-12 hrs after hatching. Positions of HSNs were scored as described in Pan et al. 2006. | Paper_evidence | WBPaper00031356 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000640 | Person_evidence | WBPerson261 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Mild Egl | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000690 | Paper_evidence | WBPaper00004408 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | Table 3 | Paper_evidence | WBPaper00004408 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Penetrance | Low | 2% penetrant | Paper_evidence | WBPaper00004408 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0005175 | PATO:0000460 | Paper_evidence | WBPaper00004408 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0000695 | Paper_evidence | WBPaper00004408 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | Table 3 | Paper_evidence | WBPaper00004408 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Penetrance | Incomplete | 11% penetrant | Paper_evidence | WBPaper00004408 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006748 | PATO:0000460 | Paper_evidence | WBPaper00004408 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0000697 | Paper_evidence | WBPaper00004408 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | Table 3 | Paper_evidence | WBPaper00004408 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Penetrance | Low | 5% penetrant | Paper_evidence | WBPaper00004408 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006748 | PATO:0000460 | Paper_evidence | WBPaper00004408 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0001140 | Person_evidence | WBPerson261 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | BDU posteriorly displaced | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006826 | PATO:0000460 | Person_evidence | WBPerson261 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001410 | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | No detectable MAB-5 antibody staining was observed in these animals, unlike in control animals. | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | High | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Recessive | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00002582 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_not_observed | WBPhenotype:0000038 | Paper_evidence | WBPaper00004408 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | Table 3 | Paper_evidence | WBPaper00004408 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0006748 | PATO:0000460 | Paper_evidence | WBPaper00004408 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBPhenotype:0000062 | Paper_evidence | WBPaper00031356 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00031356 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000070 | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | No defects were reported in the morphology of the male tail hook and rays 1-6. | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | High | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Recessive | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00002582 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000471 | Paper_evidence | WBPaper00038522 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | ALM does not exhibit significant migration defects. | Paper_evidence | WBPaper00038522 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0005406 | PATO:0000460 | Paper_evidence | WBPaper00038522 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000852 | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Coelomocytes were produced. | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | High | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Recessive | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00002582 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001235 | Paper_evidence | WBPaper00004436 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Remark | Animals exhibited wild type V5 cell division polarity (Table 2) | Paper_evidence | WBPaper00004436 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| EQ_annotations (2) | |||||||||
| Phenotype_assay | Temperature | 25 | Paper_evidence | WBPaper00004436 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Reference | WBPaper00038522 | ||||||||
| WBPaper00018522 | |||||||||
| WBPaper00018685 | |||||||||
| WBPaper00003383 | |||||||||
| WBPaper00004436 | |||||||||
| WBPaper00004408 | |||||||||
| WBPaper00010174 | |||||||||
| WBPaper00031356 | |||||||||
| WBPaper00002582 | |||||||||
| Method | Allele |
