WormBase Tree Display for Variation: WBVar00087992

WBVar00087992 Name: Public_name: it5
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00023548
    Laboratory: KK
    Status: Live
  Affects: Gene: WBGene00003917
    Interactor (25)
  Genetics: Mapping_data: In_2_point: 2721
      In_multi_point (3)
  Description: Phenotype: WBPhenotype:0000052 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: 26 percent Mel at 16C. 98 percent Mel at 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 16C, 20C, 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000054 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Remark: Some animals are severely abnormal and die during larval development Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000023 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000215 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Remark: Many newly hatched par-2 larvae also lack germ cell precursors Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000395 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Remark: Some larvae develop into morphologically normal adults but lack mature gametes Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000748 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Remark: Equal first cleavage: AB and P1 blastomeres are nearly identical in size Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000867 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: weaker phenotype than it46 Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Maternal
      WBPhenotype:0001105 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Remark: In par-2 embryos, the posterior migration of the spindle complex does not occur Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001106 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Remark: The rotation of the P1 spindle complex is disrupted and P1 blastomere sometimes divides transversely rather than longitudinally at 25C Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Penetrance: Complete: 100 percent at 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Staining with anti-tubulin antibody Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
          Temperature: 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001120 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Remark: In contrast to the wild-type division sequence, early blastomeres cleave synchronously during the first few cleavages Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001302 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Remark: par-2 embryos have either no or incomplete localization of P granules Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Staining with anti-P granule antibody Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
          Temperature: 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001504 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Penetrance: High: 76 percent of surviving adult progeny are agametic at 16C. 96 percent of surviving adult progeny are agametic at 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 16C, 20C, 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001637 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Remark: Only 20 percent of par-2 embryos produce any intestinal cells Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: 20 percent at 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001642 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Remark: The orientation of the second embryonic cleavage is altered Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001032
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Staining with anti-tubulin antibody Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
          Temperature: 25C Paper_evidence: WBPaper00001032
              Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000417 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001018 Paper_evidence: WBPaper00001032
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001032
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001032
                Curator_confirmed: WBPerson2021
  Reference: WBPaper00016484
    WBPaper00013871
    WBPaper00001032
    WBPaper00026553
    WBPaper00014312
    WBPaper00016485
    WBPaper00020804
    WBPaper00015102
  Method: Allele